A5038291626- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Gallbladder and Bile Duct Disorders
- Extracellular vesicles in disease
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Autophagy in Disease and Therapy
Nanjing Drum Tower Hospital
2016-2025
Nanjing Medical University
2009-2025
Nanjing University of Chinese Medicine
2020-2025
Shanghai Institute of Organic Chemistry
2024
Chinese Academy of Sciences
2015-2024
Jiangsu University
2014-2024
Emory University
2019-2020
Weatherford College
2020
Nanchang University
2018
Center for Excellence in Molecular Cell Science
2015
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all targeted and immune therapies. However, our understanding of PDAC microenvironment especially the very limited partly due inaccessibility tumor tissues. Here, we present single-cell transcriptomic landscape synchronously resected primary tumors matched liver metastases. We perform comparative analysis on both cellular composition functional phenotype between tumors. Tumor cells exhibit distinct profile...
Abstract Background Although using a blockade of programmed death-ligand 1 (PD-L1) to enhance T cell immune responses shows great promise in tumor immunotherapy, the immune-checkpoint inhibition strategy is limited for patients with solid tumors. The mechanism and efficacy such strategies tumors remains unclear. Results Employing qRT-PCR, Sanger sequencing, RNA BaseScope analysis, we show that human lung adenocarcinoma (LUAD) all produce long non-coding isoform PD-L1 (PD-L1-lnc) by...
Abstract Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However, drug resistance and unavoidable severe toxicity lead to chemotherapy failure poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumor progression many cancers, including GC. Here, through RNA screening, an apoptotic protease‐activating factor 1 (APAF1)‐binding lncRNA (ABL) that is significantly elevated cancerous GC tissues independent prognostic patients identified. Moreover,...
Metastasis leads to the vast majority of breast cancer mortality. Increasing evidence has shown that N6-methyladenosine (m6A) modification and its associated regulators play a pivotal role in metastasis. Here, we showed overexpression m6A reader IGF2BP1 was clinically correlated with metastasis patients. Moreover, promoted distant vitro vivo. Mechanistically, first identified USP10 as deubiquitinase. can bind to, deubiquitinate, stabilize IGF2BP1, resulting higher expression level cancer....
Current therapies primarily targeting inflammation often fail to address the root relationship between intestinal mucosal integrity and resulting dysregulated cell death ensuing in ulcerative colitis (UC). First, UC tissues from human mice models this article both emphasize crucial role of Gasdermin E (GSDME)-mediated pyroptosis epithelial cells (IECs) as it contributes by releasing proinflammatory cytokines, thereby compromising barrier. Then, 4-octyl-itaconate (4-OI), exhibiting potential...
Efficient and stable organic-silicon heterojunction solar cells are highly desirable. In this work, solution-processed poly(3,4-ethylenedioxythiophene): perfluorinated sulfonic acid (PEDOT:F) is investigated as hole-selective contact for crystalline silicon (c-Si) cells....
Hepatic injury is often accompanied by pulmonary inflammation and tissue damage, but the underlying mechanism not fully elucidated. Here we identify hepatic miR-122 as a mediator of induced various liver injuries. Analyses acute chronic mouse models confirm that dysfunction can cause damage. Injured livers release large amounts in an exosome-independent manner into circulation compared with normal livers. Circulating then preferentially transported to lungs taken up alveolar macrophages,...
We aimed to develop and validate a real-time deep convolutional neural networks (DCNNs) system for detecting early gastric cancer (EGC).All 45,240 endoscopic images from 1364 patients were divided into training dataset (35823 1085 patients) validation (9417 279 patients). Another 1514 three other hospitals used as external validation. compared the diagnostic performance of DCNN with endoscopists, then evaluated endoscopists or without referring system. Thereafter, we ability in video...
Hypoxia is a characteristic of the tumor microenvironments within pancreatic cancer (PC), which has been linked to its malignancy. Recently, hypoxia reported regulate activity important carcinogenic pathways by changing status histone modification. NOX4, member NADPH oxidase (NOX), found be activated and promote progression in several cancers. But whether it involved epigenetic changes cells induced still unclear, biological roles PC also need explored.A hypoxic-related gene signature...
BackgroundWe aimed to develop a deep learning-based segmentation system for rapid on-site cytopathology evaluation (ROSE) improve the diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy.MethodsA retrospective, multicenter, study was conducted using 5345 cytopathological slide images from 194 patients who underwent EUS-FNA. These were Nanjing Drum Tower Hospital (109 patients), Wuxi People's (30 Second (25 and The Affiliated Soochow University...
Constitutive activation of the transcription factor STAT3 (signal transducer and activator 3) contributes to malignancy many cancers such as hepatocellular carcinoma (HCC) is associated with poor prognosis. activity increased by reversible palmitoylation Cys 108 palmitoyltransferase DHHC7 (encoded ZDHHC7 ). Here, we investigated consequences S-palmitoylation in HCC. Increased abundance HCC cases was prognosis, revealed bioinformatics analysis patient data. In HepG2 cells vitro,...
// Xiaoying Zhou 1,2,* , Guifang Xu 3,* Chengqiang Yin 1,2 Wujuan Jin and Guoxin Zhang 1 Department of Gastroenterology, First Affiliated Hospital Nanjing Medical University, Nanjing, China 2 Clinical College 3 Drum Tower University School, * These authors contributed equally to the work Correspondence: Zhang, email: Keywords : miR-203; CASK; Helicobacter pylori; gastric cancer Received August 17, 2014 Accepted October 18, Published Abstract Several microRNAs (miRNA) have been implicated in...
Recently, several studies have shown that piperlongumine (PL) can selectively kill cancer cells by targeting reactive oxygen species (ROS). However, the potential therapeutic effects and detailed mechanism of PL in gastric are still not clear. In current report, we found significantly suppressed both vitro vivo. obviously increased ROS generation cells. Anti-oxidant glutathione (GSH) N-acetyl-l-cysteine (NAC) abrogate PL-induced cell death proliferation inhibition. GADD45α was induced...
Background Gastric peroral endoscopic pyloromyotomy (G-POEM) and gastric electrical stimulation (GES) have been reported as treatment options for refractory gastroparesis. In this study, we compared the long term clinical outcomes of G-POEM versus GES in such patients. Methods We retrospectively evaluated 111 consecutive patients with gastroparesis between January 2009 August 2018. To overcome selection bias, used propensity score matching (1:1) treatment. The primary outcome was duration...
Background: The aldehyde dehydrogenase 1 family member A3 (ALDH1A3) is a key enzyme associated with variety of metabolic processes, including glucose metabolism. We recently uncovered that metabolism played an essential role in promoting metastasis pancreatic ductal adenocarcinoma (PDAC). As ALDH1A3 labels aggressive subtype PDAC, we hypothesized functionally promoted PDAC via its effect on Methods: Expression was detected human tissues by immunohistochemistry. knocked down or overexpressed...
Emerging evidences demonstrate that metabolic reprogramming is a hallmark of malignancies, including gastric cancer (GC). Abnormal expression rate-limiting enzymes, as the executive medium energy metabolism, drives occurrence and development cancer. However, comprehensive model enzymes associated with progression GC remains unclear. In this research, we identified enzyme, sterol O-acyltransferase 1 (SOAT1), was highly expressed in cancerous tissues, which advanced tumor stage lymph node...
Pancreatic cancer (PC) has a dismal prognosis due to its insidious early symptoms and poor detection rate. Exosomes can be released by various cell types tend potential novel biomarker for PC detection. In this study, we explored the proteomic profiles of plasma exosomes collected from patients with at different stages other pancreatic diseases.Plasma samples were six groups patients, including stage I/II, III/IV, well-differentiated neuroendocrine tumor (P-NET), cystic lesions (PCLs),...
Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition of Receptor-Interacting Serine/Threonine-Protein Kinase 1 (RIPK1) kinase ameliorated progression motor dysfunction after onset and prolonged survival Mecp2-null mice. Microglia were activated early myeloid Mecp2-deficient mice, which was inhibited upon inactivation RIPK1 kinase. microglia reduced oxidative stress,...
Laparoscopic common bile duct exploration (LCBDE) for stone can be carried out by either laparoscopic transcystic extraction (LTSE) or choledochotomy (LC). It remains unknown as to which approach is optimal management of gallbladder with stones (CBDS) in Chinese patients. From May 2000 February 2009, we prospective treated 346 consecutive patients and CBDS cholecystectomy LCBDE. Intraoperative findings, postoperative complications, hospital stay costs were analyzed. Because LCBDE failure,16...