A5030115743- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Renal Diseases and Glomerulopathies
Nanjing University of Chinese Medicine
2019-2024
Nanjing Drum Tower Hospital
2024
Current therapies primarily targeting inflammation often fail to address the root relationship between intestinal mucosal integrity and resulting dysregulated cell death ensuing in ulcerative colitis (UC). First, UC tissues from human mice models this article both emphasize crucial role of Gasdermin E (GSDME)-mediated pyroptosis epithelial cells (IECs) as it contributes by releasing proinflammatory cytokines, thereby compromising barrier. Then, 4-octyl-itaconate (4-OI), exhibiting potential...
The Abelmoschus Manihot (AM) is one of the Traditional Chinese Medicine herbs be used in treatment some kidney diseases. total flavonoids AM (TFA) are main extracts. Up to date, detailed mechanisms by which improves kinds renal disease still not fully understood. In current study, we aimed evaluate role and TFA Adriamycin-induced tubular injury both vitro vivo.