A5100456695- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Insect Resistance and Genetics
- Cancer, Lipids, and Metabolism
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Insect Pest Control Strategies
- Sirtuins and Resveratrol in Medicine
- Protein Degradation and Inhibitors
- RNA Research and Splicing
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Orthopedic Infections and Treatments
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Entomopathogenic Microorganisms in Pest Control
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2014-2025
Nanjing Drum Tower Hospital
2017-2025
Huaian First People’s Hospital
2025
Soochow University
2025
Second Affiliated Hospital of Soochow University
2025
Nanjing University
2024
Jinan University
2024
Chongqing University
2024
Chongqing Medical University
2024
Inflammatory bowel disease (IBD)–associated dysbiosis is characterized by a loss of Faecalibacterium prausnitzii, whose supernatant exerts an anti-inflammatory effect. However, the substances in F. prausnitzii and mechanism ameliorating colitis IBD have not yet been fully investigated. Experimental models were induced evaluated clinical examination histopathology. Levels cytokines ratio T cells detected enzyme-linked immunosorbent assay flow cytometry analysis, respectively. was separated...
Metastasis is the most important feature of gastric cancer (GC) and widely recognized reason for GC-related deaths. Unfortunately, underlying mechanism behind this metastasis remains unknown. Mounting evidence suggests dynamic regulatory role sirtuin2 (SIRT2), a histone deacetylase (HDAC), in cell migration invasion. The present study aims to evaluate biological function SIRT2 GC identify target as well its therapeutic efficacy. We found that was upregulated tissues compared adjacent normal...
Ferroptosis is a newly identified form of regulated cell death (RCD) characterized by the iron-dependent lipid reactive oxygen species (ROS) accumulation, but its mechanism in gliomas remains elusive. Acyl-coenzyme A (CoA) synthetase long-chain family member 4 (Acsl4), pivotal enzyme regulation biosynthesis, benefits initiation ferroptosis, role needs further clarification. Erastin, classic inducer has recently been found to regulate peroxidation regulating Acsl4 other than glutathione...
Abstract Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However, drug resistance and unavoidable severe toxicity lead to chemotherapy failure poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumor progression many cancers, including GC. Here, through RNA screening, an apoptotic protease‐activating factor 1 (APAF1)‐binding lncRNA (ABL) that is significantly elevated cancerous GC tissues independent prognostic patients identified. Moreover,...
Abstract Background The microglia-mediated inflammatory response is a vital mechanism of secondary damage following traumatic brain injury (TBI), but the underlying microglial activation unclear. Methods Controlled cortical impact (CCI) was induced in adult male C57BL/6J mice, and glutamate used to construct classical vitro model primary microglia. Microglial determined by western blot immunostaining. factors were measured enzyme-linked immunosorbent assay. oxidative stress marker...
Objective Early gastric cardia adenocarcinoma (EGCA) is a highly heterogeneous cancer, and the understanding of its classification malignant progression limited. This study explored cellular molecular heterogeneity in EGCA using single-cell RNA sequencing (scRNA-seq). Design scRNA-seq was conducted on 95 551 cells from endoscopic biopsies low-grade intraepithelial neoplasia, well/moderately/poorly differentiated their paired adjacent nonmalignant biopsy samples. Large-scale clinical samples...
Abstract The relationship between patterns of RNA modifications and gastric cancer (GC) liver metastasis (GCLM) remains unclear. Here, by single‐cell sequencing, clinical sample analysis, mouse model studies, an abnormal increase in the expression acetyltransferase N‐acetyltransferase 10 (NAT10) metastatic GC cells is identified. NAT10‐mediated N4‐acetylcytidine modification CXCL2 KLF5 mRNA increases their stability. Then, secreted found to promote infiltration polarization M2‐like...
2-5A-dependent RNase (RNase L), a unique endoribonuclease that requires 5'-phosphorylated 2',5'-linked oligoadenylates (2-5A), functions in the molecular mechanism of interferon action. Because this enzyme is present at very low levels nature, characterization and analysis have been limited. The cloning human, cDNA has facilitated its expression to high insect cells by infecting with recombinant baculovirus. To determine properties absence other proteins, was purified homogeneity. migrated...
Abstract Gastric cancer prognoses are persistently poor due to cancer's penchant metastasize. As a crucial regulator of signal transducer and activator transcription (STAT3) signaling, sirtuin 1's (SIRT1) function in gastric has not been well understood. Here, we report upregulated expression SIRT1 tissues isolated from patients. However, show that the depletion SIRT1‐mediated enhanced cell proliferation metastasis, resulted enrichment phosphorylated STAT3, acetylated matrix...
Abstract Decreased levels of Faecalibacterium prausnitzii (F. prausnitzii), whose supernatant plays an anti-inflammatory effect, are frequently found in inflammatory bowel disease (IBD) patients. However, the products F. and mechanism have not been fully investigated. Here we that prausnitzii-derived butyrate were decreased intestines IBD Supplementation with could ameliorate colitis animal model. Butyrate, but other substances produced by prausnitzii, exerted effect inhibiting...
SOD-like activity of CeO2 nanoparticles (Ce NPs) is driven by Ce3+/Ce4+, high oxidative stress can oxidize Ce3+ to reduce the ratio inactivating SOD Ce NPs. Herein, we found Au@Ce NPs, assembled Au NPs and exhibited high-performance mimetic enzyme even upon oxidation H2O2. supported nano-Au acquire electrons from through enhanced localized surface plasmon resonance (LSPR), maintaining stability Ce3+/Ce4+ activity. Meanwhile, retained peroxidase function catalase function. As a result,...
Constitutive activation of the transcription factor STAT3 (signal transducer and activator 3) contributes to malignancy many cancers such as hepatocellular carcinoma (HCC) is associated with poor prognosis. activity increased by reversible palmitoylation Cys 108 palmitoyltransferase DHHC7 (encoded ZDHHC7 ). Here, we investigated consequences S-palmitoylation in HCC. Increased abundance HCC cases was prognosis, revealed bioinformatics analysis patient data. In HepG2 cells vitro,...
Some reports have evaluated the prognostic relevance of microRNAs (miRNAs) in patients with pancreatic cancer (PC). However, most studies focused on limited miRNAs small number patients. The aim study is to identify a panel miRNA signature that could predict prognosis PC data from Cancer Genome Atlas (TCGA). A total 167 corresponding clinical were enrolled our study. significantly associated overall survival (OS) identified Cox proportional regression model. risk score formula was developed...
Abstract Cholangiocarcinoma (CCA) is an extremely invasive malignancy with late diagnosis and unfavorable prognosis. Surgery chemotherapy are still not effective in improving outcomes CCA patients. It crucial to explore a novel therapeutic target for treating CCA. An NAD‐dependent deacetylase also known as Sirtuin‐3 (SIRT3) has been shown regulate cellular metabolism various cancers dynamically. However, the biological function of SIRT3 remains unclear. In this study, bioinformatics analyses...
Abstract Increasing evidence suggests the involvement of microRNA‐381 (miR‐381) in chemoresistance cancer treatment. However, its function and molecular mechanisms breast are still not well elucidated. In present study, we aimed to investigate functional role miR‐381 cisplatin (DDP) resistance discover underlying mechanism. The expression levels MDR1 were detected by quantitative real‐time PCR (qRT‐PCR) Western blot analysis tissues cell lines. DDP sensitivity apoptosis cells determined MTT...
Emerging evidences demonstrate that metabolic reprogramming is a hallmark of malignancies, including gastric cancer (GC). Abnormal expression rate-limiting enzymes, as the executive medium energy metabolism, drives occurrence and development cancer. However, comprehensive model enzymes associated with progression GC remains unclear. In this research, we identified enzyme, sterol O-acyltransferase 1 (SOAT1), was highly expressed in cancerous tissues, which advanced tumor stage lymph node...
Hepatocellular carcinoma (HCC) is one of the most common malignant diseases globally. Despite continuous improvement treatment methods, high postoperative recurrence rate remains an urgent problem. In order to determine mechanism underlying liver cancer and identify prognostic genes, data from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA) were integrated analyzed. Differentially expressed genes (DEGs) between HCC tissue normal identified, a protein–protein interaction network...
Abstract Persistence of Bacillus thuringiensis is an important factor in determining the success this product as a pest control agent. In report we present development highly active mosquitocidal formulation with high resistance to UV. LLP29-M19 strain Bt, selected by repeated exposure UV was found be resistant The optimized and methods used were statistically analyzed. Using single-factor experiments it determined that optimal concentration sodium alginate, CaCl 2 hollow glass beads 1.0%,...