A5031348911- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Takotsubo Cardiomyopathy and Associated Phenomena
- ECG Monitoring and Analysis
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Hemodynamic Monitoring and Therapy
- Cardiomyopathy and Myosin Studies
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Neuroscience and Neural Engineering
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Blood Coagulation and Thrombosis Mechanisms
Heidelberg University
2016-2025
University Medical Centre Mannheim
2016-2025
University Hospital Heidelberg
2016-2025
German Centre for Cardiovascular Research
2015-2024
University of Mannheim
2005-2023
University Medical Center
2009-2020
Oncoscience (Germany)
2020
University of Zurich
2018
Medizinische Fakultät Mannheim
2015-2017
University Children’s Hospital Basel
2015
Cardiac ion channelopathies are responsible for an ever-increasing number and diversity of familial cardiac arrhythmia syndromes. We describe a new clinical entity that consists ST-segment elevation in the right precordial ECG leads, shorter-than-normal QT interval, history sudden death.Eighty-two consecutive probands with Brugada syndrome were screened channel gene mutations direct sequencing. Site-directed mutagenesis was performed, CHO-K1 cells cotransfected cDNAs encoding wild-type or...
Background— Sudden cardiac death takes the lives of more than 300 000 Americans annually. Malignant ventricular arrhythmias occurring in individuals with structurally normal hearts account for a subgroup these sudden deaths. The present study describes genetic basis new clinical entity characterized by and short-QT intervals ECG. Methods Results— Three families hereditary syndrome high incidence were studied. In 2 them, we identified different missense mutations resulting same amino acid...
Background— Brugada syndrome is characterized by ST-segment elevation in the right precordial leads and an increased risk of sudden cardiac death (SCD). Fundamental questions remain on best strategy for assessing real disease-associated arrhythmic risk, especially asymptomatic patients. The aim present study was to evaluate prognosis factors SCD patients FINGER (France, Italy, Netherlands, Germany) registry. Methods Results— Patients were recruited 11 tertiary centers 4 European countries....
Background— Brugada syndrome is an arrhythmogenic disease characterized by ECG pattern of ST-segment elevation in the right precordial leads and increased risk sudden cardiac death as a result ventricular fibrillation. Controversy exists with regard to stratification therapeutic management, particularly asymptomatic individuals. Methods Results— A total 212 individuals (mean age, 45±6 years) type 1 were studied. Of these, 123 (58%) asymptomatic, 65 (31%) had ≥1 syncope unknown origin, 24...
Clinical presentation, occurrence of sudden infant death, and results the available therapies in largest group patients with short QT syndrome (SQTS), studied so far, are reported. history, physical examination, electrocardiogram (ECG), exercise stress testing, electrophysiological study, morphological evaluation, genetic analysis therapy 29 SQTS personal and/or familial history cardiac arrest The median age at diagnosis was 30 years (range 4-80). In all subjects, structural heart disease...
A rapidly growing number of long-QT syndrome (LQTS) patients are being treated with an implantable cardioverter-defibrillator (ICD). ICDs may pose problems, especially in the young. We sought to determine characteristics LQTS receiving ICD, indications, and aftermath.The study population included 233 patients. Beginning 2002, data were collected prospectively. Female (77%) LQT3 (22% genotype positive) overrepresented; mean QTc was 516±65 milliseconds; age at implantation 30±17 years; known...
Abstract Introduction The aim of this study was to evaluate the diagnostic and prognostic value presepsin in patients with severe sepsis septic shock during first week ICU treatment. Methods In total, 116 suspected or were included 24 hours Blood samples for biomarker measurements presepsin, procalcitonin (PCT), interleukin 6 (IL-6), C reactive protein (CRP) white blood cells (WBC) drawn at days 1, 3 8. All followed up six months. Biomarkers tested diagnosis sepsis, prognosis 30-days...
Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical challenge. Mechanism-based approaches to AF therapy are sought increase effectiveness and provide individualized patient care. K(2P)3.1 (TASK-1 [tandem P domains in weak inward-rectifying K+ channel-related acid-sensitive channel-1]) 2-pore-domain (K(2P)) channels have been implicated action potential regulation animal models. However, their role the pathophysiology treatment paroxysmal chronic patients with is...