A5068087689- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Bone health and osteoporosis research
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Microbial infections and disease research
- Gynecological conditions and treatments
- Body Composition Measurement Techniques
- Synthesis and biological activity
- Nutrition and Health in Aging
- Phytase and its Applications
- Uterine Myomas and Treatments
- Click Chemistry and Applications
- Endometriosis Research and Treatment
- Chaos control and synchronization
- Neurological Disease Mechanisms and Treatments
- Induction Heating and Inverter Technology
- Endometrial and Cervical Cancer Treatments
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Organic Chemistry Cycloaddition Reactions
- Cancer Immunotherapy and Biomarkers
- Crystal structures of chemical compounds
- Cancer, Hypoxia, and Metabolism
- Bacteriophages and microbial interactions
Handan College
2020-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2024
Henan University of Technology
2024
Northwest A&F University
2019-2023
China Railway Group (China)
2023
Nanjing Drum Tower Hospital
2012-2022
Shanghai Maritime University
2022
Tongji University
2022
Institute of Industrial Engineering
2022
Wenzhou Medical University
2022
Intrauterine adhesions (IUA) are the most common cause of uterine infertility and caused by endometrium fibrotic regeneration following severe damage to endometrium. Although current stem cell treatment options using different types autologous cells have exhibited some beneficial outcomes in IUA patients, reported drawbacks include variable therapeutic efficacies, invasiveness unavailability. Therefore, development new treatments is critical improving clinical outcomes. Twenty-six patients...
The present study was designed to explore the cross talk between fatty acid synthase (FASN) and HER2 (ErbB2) in ovarian cancer. A total of 60 cancer patients 15 normal tissues were enrolled. Tissue array conducted by using a tissue microarray instrument. Immunohistochemistry performed quantify expressions FASN. FASN detected be distributed cell cytoplasm significantly correlated with grade (p = 0.000) FIGO staging 0.000). Patients overexpression tend have worse overall survival rate also...
Asherman's syndrome (AS) is a common disease that presents endometrial regeneration disorder. However, little known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning for patients with AS. Here, we report ΔNp63 significantly upregulated residual epithelial cells impaired AS; upregulated-ΔNp63 induces quiescence alteration stemness. Importantly, demonstrate engrafting high density autologous bone marrow mononuclear (BMNCs) loaded...
Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the degradation of intracellular proteins in lysosomes, is upregulated tumors for pro-tumorigenic and pro-survival purposes. In this study, bioinformatics analysis revealed co-occurrence CMA PD-L1 accumulation metastatic melanoma with adaptive immune resistance (AIR) anti-PD1 treatment, suggesting potential therapeutic effects rewiring degradation. Furthermore, attributed IFN-γ-mediated compensatory up-regulation CMA,...
Objective:The low clinical utility of immune checkpoint inhibitors (ICIs) against PD-1 or PD-L1 has recently been associated with the activation Wnt/β-catenin signaling pathway in hepatocellular carcinoma (HCC), which promotes tumor escape and resistance to anti-PD-1/PD-L1 therapy.Hence, we aimed fabricate a supramolecular peptide could target coupled ICIs blockage therapy for optimizing HCC immunotherapy.Methods: A racemic spherical termed sBBI&PDP nanoparticle was constructed by...
Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes various diseases including organ fibrosis. Endometrium fibrosis is leading cause uterine infertility, but circRNAs its pathogenesis largely unknown. Here, we provide that upregulation circPTPN12 endometrial epithelial cells (EECs) fibrotic endometrium functions as endogenous sponge miR-21–5 p to inhibit expression and activity, which turn results ΔNp63α induce mesenchymal...
Significance Preeclampsia (PE) is a severe trophoblast-related disorder that threatens the health of mother and fetus. Impaired placentation in early stages pregnancy subsequent systemic endothelial cell activation constitute principle pathogenic mechanisms PE. Currently, molecules involved pathogenesis PE link two this remain elusive. Our study demonstrates CD81 associated with key pathological changes occur both placenta maternal cells patients (sPE). Importantly, overexpression induces...
Magnetic sludge with the unique flexibility, low thermal conductance and plentiful adsorption sites was fabricated for highly efficient As/Sb removal.
Background Sepsis-induced coagulopathy (SIC) is a complex condition characterized by systemic inflammation and coagulopathy. This study aimed to develop validate machine learning (ML) model predict SIC risk in patients with sepsis. Methods Patients sepsis admitted the intensive care unit (ICU) between March 1, 2021, 2024, at Hebei General Hospital Handan Central (East District) were retrospectively included. categorized into non-SIC groups. Data split training (70%) testing (30%) sets....
Compensation and intracellular storage of PD-L1 may compromise the efficacy antibody drugs targeting conformational blockade PD1/PD-L1 on cell surface. Alternative therapies aiming to reduce overall cellular abundance thus might overcome resistance conventional immune checkpoint blockade. Here we show by bioinformatics analysis that colon adenocarcinoma (COAD) with high microsatellite instability (MSI-H) presents most promising potential for this therapeutic intervention, could be controlled...
Alzheimer's disease is characterized by the accumulation and deposition of Aβ peptides in human brains induced free radical-mediated damage one hypotheses. In present study, we explored protective effects hyperbaric oxygen (HBO) Ginkgo Biloba extract (EGB761) on Aβ25-35-induced brain toxicity. Our results demonstrated that EGB761, HBO, combination HBO could significantly improve cognitive function AD rats' model, especially group. What's more, activities superoxide dismutase (SOD) rat...
Preeclampsia (PE) is a pregnancy-related syndrome characterized by new-onset hypertension and proteinuria after gestational 20 weeks. Oxidative stress, resulting from the imbalance between production of oxidants antioxidants in placentas, recognized as key pathology PE. To date, molecules that regulate remain unclear. CD151, member tetraspanins, an important regulator many physiological functions. However, function CD151 oxidative stress its association with complications are currently...
Inducing lipid peroxidation and subsequent ferroptosis in cancer cells provides a potential approach for anticancer therapy. However, the clinical translation of such therapeutic agents is often hampered by resistance acquired drug tolerance host cells. Emerging nanoplatform-based cascade engineering sensitization p53 viable rescue strategy. Herein, metallo-organic supramolecular (Nano-PMI@CeO2) toward restoration synergistic constructed, which radical generating module-CeO2 nanoparticles...
Sepsis is a highly life-threatening disease. Long non-coding RNA urothelial carcinoma associated 1 (lncRNA UCA1) participates in the processes of inflammation and organ injury several diseases, whereas its role sepsis patients still unclear. The aim was to explore clinical value lncRNA UCA1 patients.One hundred seventy-four 100 age gender-matched controls were enrolled. LncRNA peripheral blood mononuclear cell samples examined, level inflammatory cytokines serum assessed.LncRNA expressed...
The optimisation design of air‐cored axial flux permanent magnet (PM) generator is a complex non‐linear problem with constraints, multi‐objective, multivariable and multi‐peak value. different variables will affect the same goal. In this paper, multi‐objective PM based on Taguchi–response surface method (RSM) proposed. main characteristics efficiency, power quality, induction electromotive force other are taken as objectives. parameter ranges that influence objectives motor selected...