A5113751355- Reproductive System and Pregnancy
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Aortic Disease and Treatment Approaches
- Connective tissue disorders research
- Aortic aneurysm repair treatments
- Neurogenesis and neuroplasticity mechanisms
- Pregnancy and preeclampsia studies
- X-ray Diffraction in Crystallography
- MicroRNA in disease regulation
- Erythrocyte Function and Pathophysiology
- Circular RNAs in diseases
- Crystallization and Solubility Studies
- Mycobacterium research and diagnosis
- Agricultural Innovations and Practices
- Bone Tissue Engineering Materials
- Cancer Cells and Metastasis
- Advanced Fiber Laser Technologies
- Oral microbiology and periodontitis research
- Land Use and Ecosystem Services
- Advanced biosensing and bioanalysis techniques
- Caveolin-1 and cellular processes
- Tuberculosis Research and Epidemiology
Nanjing Drum Tower Hospital
2019-2025
University of South China
2024-2025
Hainan Provincial Hospital of Traditional Chinese Medicine
2024
Wenzhou Medical University
2023-2024
Wuhan Polytechnic University
2024
Shandong University
2024
The Fourth People's Hospital
2021-2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2023
First Affiliated Hospital of Wenzhou Medical University
2023
Thin endometrium has been widely recognized as a critical cause of infertility, recurrent pregnancy loss, and placental abnormalities; however, access to effective treatment is formidable challenge due the rudimentary understanding pathogenesis thin endometrium. Here, we profiled transcriptomes human endometrial cells at single-cell resolution characterize cell types, their communications, underlying mechanism growth in normal during proliferative phase. Stromal were most abundant type...
Host–guest interactions involved immunoaffinity superparamagnetic nanoparticles for fast, high-efficiency and high-purity exosome isolation elution.
Intrauterine adhesions (IUA), characterized by endometrial fibrosis, is a common cause of uterine infertility. We previously demonstrated that partial epithelial-mesenchymal transition (EMT) and the loss epithelial homeostasis play vital role in development fibrosis. As pro-survival strategy maintaining cell tissue homeostasis, macroautophagy/autophagy, conversely, may participate this process. However, autophagy fibrosis remains unknown. Here, we defective endometria IUA patients, which...
Magnetic guanidyl-functionalized metal–organic framework (MOF) nanospheres with multi-affinity sites (inherent Zn–O cluster, amino group, and guanidyl group) for efficient enrichment of global phosphopeptides.
Abstract Downstream studies of circulating tumor cells (CTCs), which may provide indicative evaluation information for therapeutic efficacy, cancer metastases, and prognosis, are seriously hindered by the poor purity enriched CTCs as large amounts interfering leukocytes still nonspecifically bind to isolation platform. In this work, biomimetic immunomagnetic nanoparticles (BIMNs) with following features designed: i) leukocyte membrane camouflage, could greatly reduce homologous interaction...
We previously demonstrated that baicalin had efficacy against gouty arthritis (GA) by oral administration. In this paper, a novel baicalin-loaded microemulsion-based gel (B-MEG) was prepared and assessed for the transdermal delivery of GA. The preparation method capability B-MEG screened optimized using central composite design, Franz diffusion cell experiments, split-split plot design. Skin irritation tests were performed in guinea pigs. anti-gout effects evaluated mice. comprised 50 % pH...
Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating into diverse types mature functional in vivo challenging. In this study, engineered embryonic cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing (hscNPCs) to differentiate various on collagen scaffold vitro. Transplantation DV-SC complete SCI models rats monkeys showed better therapeutic effects...
Abstract Epithelial homeostasis plays an essential role in maintaining endometrial function. But the epithelial fibrosis has been less studied. Previously, we showed that ectopic expression of ΔNp63α is associated with process and dysfunction endometria patients intrauterine adhesions (IUAs). Since profoundly involved homeostasis, hereby focused on its roles regulating function phenotype cells (EECs) context fibrosis. We identified a typical type 2 epithelial-to-mesenchymal transition (EMT)...
Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes various diseases including organ fibrosis. Endometrium fibrosis is leading cause uterine infertility, but circRNAs its pathogenesis largely unknown. Here, we provide that upregulation circPTPN12 endometrial epithelial cells (EECs) fibrotic endometrium functions as endogenous sponge miR-21–5 p to inhibit expression and activity, which turn results ΔNp63α induce mesenchymal...
Abstract Chemicals or drugs can accumulate within biomolecular condensates formed through phase separation in cells. Here, we use super-resolution imaging to search for chemicals that induce transition chromatin at the microscale. This microscopic screening approach reveals adriamycin (doxorubicin) — a widely used anticancer drug is known interact with specifically induces visible local condensation and global conformational change of cancer primary Hi-C ATAC-seq experiments systematically...
Thin endometrium (TE) is a challenging clinical issue in the reproductive medicine characterized by inadequate endometrial thickness, poor response to estrogen and no effective treatments currently. At present, precise pathogenesis of thin endometria remains be elucidated. We aimed explore related molecular mechanism TE comparing transcriptome profiles late-proliferative phase between matched controls.We performed bulk RNA-Seq (RNA-sequencing) tissues 7 controls for first time. Differential...
Various mature tissue-resident cells exhibit progenitor characteristics following injury. However, the existence of endogenous stem with multiple lineage potentials in adult spinal cord remains a compelling area research. In this study, we present cross-species investigation that extends from development to We used single-nucleus transcriptomic sequencing and genetic tracing characterize neural cord. Our findings show ciliated ependymal lose gene signatures proliferation ability...
Effective biomarkers for the diagnosis of metabolic dysfunction-associated steatotic liver disease (MASLD) remain limited. This study aims to evaluate potential advanced glycation end products (AGEs) and their endogenous secretory receptor (esRAGE) as non-invasive diagnosing MASLD, explore differences between obese non-obese MASLD patients, develop a novel diagnostic model based on these biomarkers. enrolled 341 participants, including 246 patients (118 non-obese, 128 obese) 95 healthy...
The clinical success of dental implants requires not only the optimum osseointegration but also integration implant surface with soft tissues to form biological sealing. In this study, alkali-heat treatment was applied modify pure titanium constructing a unique micro-and nano-structure. Then, poly(dopamine), along and additional incorporation hydroxyapatite carboxymethyl chitosan have been successfully infiltrated into preactivated Ti during dopamine self-polymerization proceeding. Here,...
A novel polymer brush-functionalized magnetic composite nanosphere was successfully prepared, exhibiting large enrichment capacity, extremely high detection sensitivity, and recovery in phosphorylated biomolecule enrichment.
An inflammatory reaction initiates fracture healing and directly influences the osteoinductive effect of magnetic hydroxyapatite (MHA) scaffold, but underlying mechanism is yet to be elucidated.
Objective To investigate the positivity rates and drug resistance characteristics of Mycobacterium tuberculosis (MTB) among suspected (TB) patients in Shandong Province, second-largest population province China. Methods A prospective, multi-center study was conducted from April 2022 to June 2023. Pathogen were identified using nucleotide matrix-assisted laser desorption ionization time-of-flight mass spectrometry (nucleotide MALDI-TOF MS). Results Of 940 TB included this study, 552 cases...
The progression of systemic lupus erythematosus (SLE) leads to anemia in patients, adversely affecting prognosis. diverse causes may include excessive eryptosis or premature suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine (PS) exposure on the surface. present study explored if SLE enhances underlying mechanisms.Eryptosis was assessed using flow cytometry healthy volunteers (n = 20) anemic patients hospitalized for 22), parameters including PS exposure,...