A5103052180- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Synthesis and Reactivity of Heterocycles
- Neurogenesis and neuroplasticity mechanisms
- Advanced MEMS and NEMS Technologies
- Advancements in Transdermal Drug Delivery
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Synthesis and pharmacology of benzodiazepine derivatives
- Photonic and Optical Devices
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Tissue Engineering and Regenerative Medicine
- Semiconductor Lasers and Optical Devices
- Catalytic C–H Functionalization Methods
- Mesenchymal stem cell research
- Synthesis and Reactions of Organic Compounds
- Force Microscopy Techniques and Applications
- Fluorine in Organic Chemistry
Jiangnan University
2022-2025
Wuxi Institute of Technology
2025
Nanjing Tech University
2025
China Association for Science and Technology
2025
Jilin University
2014-2024
Inner Mongolia Medical University
2023
Chinese Academy of Sciences
2012-2023
Institute of Genetics and Developmental Biology
2018-2023
North China Electric Power University
2014-2022
China Electric Power Research Institute
2021-2022
Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is developing safer more effective therapies. Recent work has highlighted noncanonical modes of dopamine D 2 receptor (D R) signaling via β-arrestins as being important therapeutic actions antimanic agents. We thus sought to create unique R agonists that display bias β-arrestin–ergic signaling. Through a robust diversity-oriented modification scaffold represented by...
Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and noncanonical signaling, are extremely useful for elucidating key signal transduction pathways essential both the therapeutic actions side effects of drugs. However, few such ligands have been created, very little purposeful attention has devoted to studying what we term: "structure-functional selectivity relationships" (SFSR). We recently disclosed first β-arrestin-biased dopamine...
DNA vaccines are simple to produce and can generate strong cellular humoral immune response, making them attractive vaccine candidates. However, a major shortcoming of is their poor immunogenicity when administered intramuscularly. Transcutaneous immunization (TCI) via microneedles promising alternative delivery route enhance the vaccination efficacy. A novel dissolving microneedle array (DMA)-based TCI system loaded with cationic liposomes encapsulated hepatitis B adjuvant CpG ODN was...
Abstract Background Emerging evidence suggests that miR-124 performs important biological functions in neural stem cells (NSCs); it regulates NSC behavior and promotes the differentiation of NSCs into neurons, but exact molecular mechanism remains unknown. And also, role during spinal cord injury regeneration is unclear. Materials methods In order to explore function differentiation, markers (Tuj1, Map2, GFAP) correlated with were detected by immunofluorescence staining both cultured mouse...
Noncovalent interactions between cells and environmental cues have been recognized as fundamental physiological that regulate cell behavior. However, the effects of covalent biomaterials on behavior not examined. Here, we demonstrate a combined strategy based conjugation (collagen fibers/lipid nanoparticles) various (exogenous neural progenitor cells/astrocytes/endogenous tissue-resident cells) to promote regeneration after spinal cord injury (SCI). We found metabolic azido-labeled human...
Three new Ln2Ni (Ln = Gd, Sm, Tb) heterometallic compounds templated by C 2 O 4 2− anions were synthesized. The magnetic investigation showed that Gd2Ni displays an excellent low-field MCE (−Δ S m 25.1 J kg −1 K for 2.0 T at K).
Neural stem cells (NSCs) transplantation is a promising strategy to restore neuronal relays and neurological function of injured spinal cord because the differentiation potential into functional neurons, but transplanted NSCs often largely diffuse from site mainly differentiate glial rather than neurons due adverse microenviornment after injury (SCI). This paper fabricates dual collagen scaffold tethered with collagen‐binding epidermal growth factor receptor (EGFR) antibody simultaneously...
Neural stem/progenitor cell (NSPC)-based spinal cord injury (SCI) therapy is expected to bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells.
A novel cascade reaction of aminopyrimidines 1 with N-alkyl amino acids or analogues was investigated. The keys to this are the isomerization an iminium ion formed between aldehyde group in pyrimidine and secondary amine acid, subsequent cyclization neighboring group. This sequence could be useful synthesis tetrahydropyrimido[4,5-d]pyrimidine libraries.
To evaluate the efficacy of a functional microarray microneedles (MNs) plus topical tranexamic acid (TA) for melasma in middle-aged women China. Thirty female subjects with were enrolled this study. The left or right side face was chosen randomly to be pretreated MNs, followed by 0.5% TA solution once per week 12 weeks. other half-face control, treated sham device solution. At baseline and at weeks 4, 8, treatment, clinical (photographic) evaluations parameters determined Visia recorded. 12,...
Producing gradients of biological cues into nerve conduits is crucial for guidance and regeneration. Herein, the fabrication stromal cell-derived factor-1α (SDF1α) on electrospun collagen mats reported using an electrohydrodynamic jet printing technique. The various SDF1α gradated patterns fibrous successfully demonstrated including shallow continuous gradient, steep step gradient by controlling processing parameters. graded scaffolds show a long-term stable as fused with unique peptide...
Fucoidan exhibits several pharmacological activities and is characterized by high safety the absence of toxic side effects. However, absorption fucoidan not well-characterized. In present study, were labeled with fluorescein isothiocyanate (FITC) their ability to traverse a monolayer Caco-2 cells was examined. The apparent permeability coefficients (Papp × 10−6) FITC-labeled (FITC-fucoidan) 26.23, 20.15, 17.93, 16.11 cm/sec, respectively, at concentration 10 μg/mL 0.5, 1, 1.5 2 h....
Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating into diverse types mature functional in vivo challenging. In this study, engineered embryonic cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing (hscNPCs) to differentiate various on collagen scaffold vitro. Transplantation DV-SC complete SCI models rats monkeys showed better therapeutic effects...
Neural stem progenitor cell (NSPC) transplantation has been regarded as a promising therapeutic method for spinal cord injury (SCI) repair. However, different NSPCs may have effects, and it is therefore important to identify the optimal NSPC type. In our study, we compared transcriptomes of human fetal brain-derived (BNSPCs), cord-derived (SCNSPCs) H9 embryonic stem-cell derived (H9-NSPCs) in vitro subsequently transplanted each type on collagen scaffold into T8-9 complete SCI rat model...
ConspectusHeterocycles are often found as the structural nucleus in natural products and biological active compounds. Consequently, research toward discovery development of novel efficient synthetic methodologies is constant interest to organic chemists. Diels–Alder reactions powerful at forming multiple bonds simultaneously, with stereoselectivity, thus one most widely used syntheses. Inverse electron-demand (IEDDA) reactions, a subclass have been developed for synthesis various...