A5077997506- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Neurofibromatosis and Schwannoma Cases
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Spinal Fractures and Fixation Techniques
- Parasitic infections in humans and animals
- Cancer Cells and Metastasis
- Parkinson's Disease Mechanisms and Treatments
- Vascular Malformations Diagnosis and Treatment
- Parasite Biology and Host Interactions
- Head and Neck Surgical Oncology
- MicroRNA in disease regulation
- Parasites and Host Interactions
- Circular RNAs in diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
Hebei Medical University
2024
Anhui University
2024
Jiangxi Provincial People's Hospital
2021-2023
First Affiliated Hospital of Jiangxi Medical College
2023
Chongqing University
2022
First Affiliated Hospital of Nanchang University
2021
Nanchang University
2021
Soil and Fertilizer Institute of Hunan Province
2021
Purpose: Diabetes is one of the most prevalent chronic diseases in world, and its prevalence expected to rise further. To help understand utility ratio non-high-density lipoprotein cholesterol high-density (NHHR) diabetes prevention, this large-scale longitudinal cohort study aims explore association NHHR with risk compare it as a predictor conventional lipid parameters. Patients Methods: This observational extracted data from NAGALA conducted Japan between 2004 2015. Multivariate Cox...
Abstract Spinal cord injury (SCI) can lead to locomotor deficits, and the repair of chronic SCI is considered one most challenging clinical problems. Although extensive studies have evaluated treatments for acute in small animals, comparatively fewer been conducted on large-animal phase, which more clinically relevant. Here, we used a collagen-based biomaterial, named NeuroRegen scaffold, loaded with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) canine model. To generate...
Chronic diabetic wounds, which are associated with persistent inflammation and impaired angiogenesis, occur frequently in patients. Some studies have shown that separate administration of vascular endothelial growth factor (VEGF) or stromal cell derived 1α (SDF-1α) exhibited a therapeutic effect promoting angiogenesis the wound healing process. In this study, collagen membrane is prepared as drug delivery scaffold to investigate whether combined SDF-1α VEGF has synergistic on healing. We...
Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating into diverse types mature functional in vivo challenging. In this study, engineered embryonic cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing (hscNPCs) to differentiate various on collagen scaffold vitro. Transplantation DV-SC complete SCI models rats monkeys showed better therapeutic effects...
Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice via regulation of intestinal flora lipopolysaccharide-related TLR4/MyD88/NF-κB TLR4/IL-22/STAT3 signaling pathways.
Complete transection spinal cord injury (SCI) severely disrupts the integrity of both neural circuits and microvasculature system. Hence, fabricating a functional bio-scaffold that could coordinate axonal regeneration vascular reconstruction in lesion area may emerge as new paradigm for complete SCI repair. In this study, photosensitive hydrogel scaffold loaded with collagen-binding stromal cell-derived factor-1a Taxol liposomes is capable inducing migration endothelial cells promoting...
Epilepsy affects over 70 million people globally, with temporal lobe epilepsy hippocampal sclerosis (TLE-HS) often progressing to a drug-resistant state. Recent research has highlighted the role of reactive astrocytes and glutamate dysregulation in pathophysiology. This study aims investigate involvement astrocytic xCT, glutamate-cystine antiporter, its regulation by m6A reader protein YTHDC2 TLE-HS.
Spinal cord injury (SCI) remains a formidable challenge in biomedical research, as the silencing of intrinsic regenerative signals most spinal neurons results an inability to reestablish neural circuits. In this study, we found that with low axonal regeneration after SCI showed decreased extracellular signal-regulated kinase (ERK) phosphorylation levels. However, expression dual specificity phosphatase 26 (DUSP26)─which negatively regulates ERK phosphorylation─was reduced considerably...
Deregulation of aerobic glycolysis is a common phenomenon in human cancers, including glioblastoma (GBM). In the present study, we demonstrated that natural compound xanthohumol has profound anti-tumor effect on GBM via direct inhibition glycolysis. Xanthohumol suppressed cell proliferation and colony formation cells, significantly impaired glucose metabolism inhibiting Hexokinase 2 (HK2) expression. We down-regulation c-Myc was required for xanthohumol-induced decrease HK2. destabilization...
Purpose: Glioma is the most common malignant brain tumor. The molecular mechanisms underlying its malignancy are not fully understood. LAMC1, which encodes extracellular matrix protein laminin γ1, has been implicated in some tumors but systematically evaluated glioma. aim of this study was to evaluate expression LAMC1 and clinical significance. Patients methods: 52 fresh-frozen specimens different pathological grade gliomas 5 normal tissues detected by Western blotting. Immunohistochemistry...
A binary-drug modified scaffold is able to promote both axonal and neuronal regeneration in complete spinal cord injury model. Moreover, it also facilitates synaptic formation of the regenerated neurons axons for motor function improvement.
Spinal cord injury (SCI) activates nestin
Structural-functional coupling (SFC) has shown great promise in predicting postsurgical seizure recurrence patients with temporal lobe epilepsy (TLE). In this study, we aimed to clarify the global alterations SFC TLE and predict their surgical outcomes using features. This study analyzed presurgical diffusion functional magnetic resonance imaging data from 71 48 healthy controls (HCs). were categorized into seizure-free (SF) non-seizure-free (nSF) groups based on recurrence. Individual...
In this study, our findings indicated that FOXO1 expression frequently decreased in glioma tissues and cells. decrease correlated with progression predicted a worse overall survival of patients. Restored inhibited cells invasion suppressed proliferation vitro growth vivo. Additionally, we found KLF4 increased negatively expression. Bioinformatics analysis experimental results transcriptionally repressed Moreover, increase poorer knockdown attenuated growth. These data provide rationale for...