A5101552361- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Pharmacological Effects and Toxicity Studies
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
- Cellular Mechanics and Interactions
- Immune cells in cancer
- Distributed Control Multi-Agent Systems
- Genetics and Neurodevelopmental Disorders
- Robotics and Automated Systems
- Intracranial Aneurysms: Treatment and Complications
- Sparse and Compressive Sensing Techniques
- Wireless Signal Modulation Classification
- Cancer Immunotherapy and Biomarkers
- Vascular Malformations Diagnosis and Treatment
- Neural Networks Stability and Synchronization
- Human Mobility and Location-Based Analysis
Xiangya Hospital Central South University
2015-2025
Central South University
2015-2025
Sun Yat-sen University
2018-2023
Sun Yat-sen University Cancer Center
2023
Chinese University of Hong Kong, Shenzhen
2023
Shenzhen Research Institute of Big Data
2023
Massachusetts General Hospital
2018
Harvard University
2018
Sixth Affiliated Hospital of Sun Yat-sen University
2018
Chongqing University
2014
ABSTRACT Temozolomide (TMZ)‐based chemotherapy is a standard strategy for glioma, while chemoresistance remains major therapeutic challenge. Recent evidence highlights the crucial regulatory roles of long non‐coding RNAs (lncRNA) in tumor biology. However, and mechanisms lncRNA cancer susceptibility candidate 2 (CASC2), glioma tumorigenesis are poorly understood. In this study, CASC2 expression was down‐regulated tissues cell lines, related to clinicopathologic features shorter survival...
Temozolomide (TMZ) is the most commonly used alkylating agent in glioma chemotherapy. However, growing resistance to TMZ remains a major challenge for clinicians. Recent evidence emphasizes key regulatory roles of non-coding RNAs (lncRNAs and miRNAs) tumor biology, including chemoresistance cancers. little known about role regulation mechanisms lncRNA cancer X-inactive specific transcripts (XIST) tumorigenesis chemotherapy resistance. In present study, higher XIST expression was observed...
Background: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled that mediate neuronal excitability and synaptic plasticity in the central nervous system, emerging evidence suggests a role of mGluRs biology cancer. Previous studies showed mGluR1 was potential therapeutic target for treatment breast cancer melanoma, but its human glioma has not been determined. Methods: In present study, we investigated effects inhibition U87 cells using specific targeted small interfering RNA...
Radioresistance remains a major challenge in the treatment of glioblastoma multiforme (GBM). Recent data strongly suggests important role miRNAs cancer progression and therapeutic response. Here, we have established radioresistant human GBM cell line U87R derived from parental U87 found miR-135b expression was upregulated cells. knockdown reversed radioresistance cells, overexpression enhanced Mechanically, bioinformatics analysis combined with experimental demonstrated GSK3β (Glycogen...
Valproic acid (VPA), an established antiepileptic drug, was assessed for antitumor activity, including its effects on glioblastoma, but role has not been determined.In the present study, we investigated VPA-induced apoptosis human U87 cells by cell viability, lactate dehydrogenase (LDH) release, TUNEL/Hoechst staining and flow cytometric in vitro, then further explored underlying molecular mechanisms using selective antagonists PD98059, LY294002 SB216763.The data showed that VPA...
Although epithelial membrane protein 3 (EMP3) has been implicated as a candidate tumor suppressor gene for low grade glioma, its biological function in glioblastoma multiforme (GBM) still remains poorly understood. Herein, we showed that EMP3 was highly expressed CD44-high primary GBMs. Depletion of expression suppressed cell proliferation, impaired vitro tumorigenic potential and induced apoptosis GBM lines. We also identified TGF-β/Smad2/3 signaling pathway target EMP3. interacts with...
// Songhua Xiao 1, * , Zhen Yang 2, Xingsheng Qiu 3, Ruiyan Lv 1 Jun Liu Ming Wu 4 Yiwei Liao Qing Department of Neurology, Sun Yat-Sen Memorial Hospital, University, Guanzhou, Guangdong, China 2 Hypertension and Vascular Disease, The First Affiliated Guangzhou, 3 Radiation Oncology, Yat-sen Neurosurgery, Xiangya Central South Changsha, Hunan, These authors have contributed equally to this work Correspondence to: Liu, email: chingliucn@yahoo.com Keywords: glioblastoma, TMZ, MGMT, miR-29c,...
Increasing evidence indicates that BAF53a is crucial for embryonic development and maintenance of stemness, may be associated with epithelial-mesenchymal transition (EMT), which suggests its involvement in cancer progression. However, the role glioma remains unknown. In present study, was found to highly expressed tissues poor overall survival (OS) progression-free (PFS) patients. A multivariate Cox regression analysis revealed might an independent prognostic factor OS PFS Further functional...
Glioblastoma multiforme (GBM) is one of the most malignant types central nervous system (CNS) tumors. N6-methyladenine (m6A) RNA modification a main type in eukaryotic cells. In this study, we find that m6A methylation eraser FTO dramatically downregulated glioma samples and cell lines, particularly intermediate core regions hypoxia-challenged vitro, overexpression inhibits hypoxia-induced capacities cells to proliferate, migrate invade, decreases percentage with methylation. vivo, tumor...
Cerebral ischemia-reperfusion injury (CIRI) is a leading cause of neurological impairment in stroke, primarily correlated to oxidative stress, inflammation, and ferroptosis. This study investigates the neuroprotective effects hirudin on CIRI, focusing its role modulating neuronal survival, ferroptosis markers through inhibition CCL2. A middle cerebral artery occlusion (MCAO) model mice an oxygen-glucose deprivation/reoxygenation (OGD/R) HT22 cells were used simulate ischemic conditions....
Abstract Background An increasing number of studies have shown that circular RNAs (circRNAs) play important roles in the regulation tumor progression. Therefore, we explored expression characteristics, function, and related mechanism newly identified circNALCN glioma. Methods RNA sequencing was used to analyze profiles circRNAs brain tissue from five glioma cases four normal controls. Quantitative real-time polymerase chain reaction implemented examine levels circNALCN, miR-493-3p,...
Valproic acid (VPA), a drug widely used to treat manic disorder and epilepsy, has recently shown neuroprotective effects in several neurological diseases, particularly Parkinson's disease (PD). The goal of the present study was confirm VPA's dose-dependent propensities MPP+ model PD primary dopamine (DA) neurons investigate underlying molecular mechanisms using specific mitogen-activated protein kinases (MAPKs) phosphatidylinositol 3-kinase- (PI3K-) Akt signaling inhibitors. VPA reversed...
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1 IDH2), are present most gliomas. IDH1 mutation is an important prognostic marker glioma. However, its regulatory mechanism glioma remains incompletely understood. miR-182-5p expression was increased within IDH1-mutant specimens according to TCGA, CGGA, online dataset GSE119740, as well collected clinical samples. (R)-2-hydroxyglutarate ((R)-2HG) treatment up-regulated the of miR-182-5p, enhanced cell proliferation, suppressed apoptosis;...
Context: It has been verified that dendritic cell (DC) vaccination can improve the prognosis of malignant glioma. However, recent evidence suggests problems with DC vaccines lies, at least in part, cancers ability to induce an immunosupressive response suppresses any vaccine-mediated active immunity. Our previous studies indicate subcutaneous vaccine restrain cancer cells implanted brain, but effect is limited on vascularized tumor brain. Furthermore, vascular endothelial growth factor...
Malignant glioma is an aggressive type of cancer. Increasing evidence has suggested that microRNAs (miRs) regulate gene expression post-transcriptionally to affect cancer development and progression. Aberrant miR-509-3p been reported in studies. However, the mechanism its function remains unclear. The present study demonstrated was downregulated tissue samples relative non-tumor tissues, low associated with a reduced overall survival time. Functional studies revealed overexpression inhibited...