A5038269506- Transcranial Magnetic Stimulation Studies
- Migraine and Headache Studies
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Ectopic Pregnancy Diagnosis and Management
- Photoreceptor and optogenetics research
- Neural and Behavioral Psychology Studies
- Pain Management and Treatment
- Retinal Development and Disorders
- Obsessive-Compulsive Spectrum Disorders
- Pregnancy and preeclampsia studies
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Electroconvulsive Therapy Studies
- DNA Repair Mechanisms
- Advanced Fluorescence Microscopy Techniques
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
ShanghaiTech University
2022-2025
Shanghai Jiao Tong University
2022-2024
Shanghai Mental Health Center
2022-2024
Shanghai Hospital Development Center
2024
Vision is initiated by the reception of light photoreceptors and subsequent processing via downstream retinal neurons. Proper circuit organization depends on multifunctional tissue polarity protein FAT3, which required for amacrine cell connectivity lamination. Here, we investigated function Fat3 mutant mice found decreases in both electroretinography perceptual responses to high-frequency flashes. These defects did not correlate with abnormal wiring, pointing instead a role bipolar subtypes...
Abstract Chemicals or drugs can accumulate within biomolecular condensates formed through phase separation in cells. Here, we use super-resolution imaging to search for chemicals that induce transition chromatin at the microscale. This microscopic screening approach reveals adriamycin (doxorubicin) — a widely used anticancer drug is known interact with specifically induces visible local condensation and global conformational change of cancer primary Hi-C ATAC-seq experiments systematically...
Ruptured ectopic pregnancy (REP), a complication caused by aberrant implantation, deep invasion, and overgrowth of embryos in fallopian tubes, could lead to rupture tubes accounts for 4%-10% pregnancy-related deaths. The lack phenotypes rodents hampers our understanding its pathological mechanisms. Here, we employed cell culture organoid models investigate the crosstalk between human trophoblast development intravillous vascularization REP condition. Compared with abortive (AEP), size...
Abstract Background The problem of suicide has become increasingly common in individuals with major depressive disorder (MDD). Transcranial direct current stimulation (tDCS) is an effective treatment for MDD 2 milliamperes (mA) at least 30 min per day weeks. This study aims to investigate the efficacy daily duration-doubled tDCS as adjunctive intervention rapidly reducing suicidal ideation and improving depression patients. Methods In this double-blind, randomized, sham-controlled study, 76...
Abstract Background Treatment-resistant depression (TRD) carries a high economic burden worldwide. Transcranial direct current stimulation (tDCS) is advantageous for improving cognition and can be safely used in the treatment of depression. The effectiveness tDCS left right orbitofrontal cortex (OFC) as adjuvant patients with TRD has rarely been explored. Therefore, objective this trial to evaluate there when administering dorsolateral prefrontal (DLPFC) positive or OFC negative TRD. Methods...
We investigated whether changes through doubling the duration of each tDCS session would increase efficacy for depression. was applied 10 sessions, followed by two additional weekly sessions. 63 patients with MDD underwent randomization, 22 being assigned to 60-min/d group, 25 30 min/d and 16 sham group. HAMD-17 reductive ratios at week 2 4 were no significant differences among treatment groups. 60 min group had a greater decrease in anxiety compared based on HAMA weeks but only completer...
There is a lack of research on transcranial direct current stimulation (tDCS) for the treatment somatic symptoms in major depressive disorder (MDD) and suitable stimulating brain region. We investigated efficacy tDCS targeting dorsolateral prefrontal cortex (DLPFC) versus orbitofrontal (OFC) anxiety patients with MDD aimed to identify appropriate regions.
Summary Tubal ectopic pregnancy (TEP), a complication caused by aberrant implantation in fallopian tubes, accounts for 9-13% pregnancy-related deaths. The lack of models human TEP hampers the understanding its pathological mechanisms. Here, we employed multiple to investigate crosstalk between trophoblast development and intravillous vascularization. We found that severity TEP, size placental villi, depth invasion are correlated with extent identified key pro-angiogenic factor secreted...
Background: Anhedonia, the core symptom of major depressive disorder (MDD), is highly prevalent in patients with depression. Anhedonia associated low efficacy drug treatment, high suicide rates, and poor social function. Transcranial direct current stimulation (tDCS) a non-invasive neuromodulation technology that uses constant, low-intensity to treat MDD by regulating cortical activity neuronal excitability. However, little known about tDCS for treating anhedonia depression, even existing...
Abstract Vision is initiated by the reception of light photoreceptors and subsequent processing via downstream retinal neurons. Proper cellular organization depends on multi-functional tissue polarity protein FAT3, which required for amacrine cell connectivity lamination. Here we investigated function Fat3 mutant mice found decreases in physiological perceptual responses to high frequency flashes. These defects did not correlate with abnormal wiring, pointing instead a role bipolar subtypes...
Abstract Backgroud: The problem of suicide has become increasingly common in individuals with major depressive disorder (MDD). Transcranial direct current stimulation (tDCS) is an effective treatment for MDD with2 milliamperes (mA) at least thirty minutes per day two weeks. This study aims to investigate the efficacy daily duration-doubled tDCS as adjunctive intervention rapidly reducing suicidal ideation and improving depression patients. Methods design: In this double-blind, randomized,...