A5101623528- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Breast Cancer Treatment Studies
- interferon and immune responses
- Cancer Risks and Factors
- Pharmacological Effects and Assays
- TGF-β signaling in diseases
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Animal Virus Infections Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Natural product bioactivities and synthesis
- PI3K/AKT/mTOR signaling in cancer
- Mast cells and histamine
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Genetic Syndromes and Imprinting
- Metastasis and carcinoma case studies
- Analytical chemistry methods development
First Affiliated Hospital of Xi'an Jiaotong University
2008-2024
China Agricultural University
2023
Changhai Hospital
2019
Fudan University
2019
Second Military Medical University
2019
Xi'an Jiaotong University
2009
Hubei University of Chinese Medicine
1995
Abstract Hyperparathyroidism (HPT) manifests as a complex condition with substantial disease burden. While advances have been made in surgical interventions and non-surgical pharmacotherapy for the management of hyperparathyroidism, radical options to halt underlying progression remain lacking. Identifying putative genetic drivers exploring novel drug targets that can impede HPT critical unmet needs. A Mendelian randomization (MR) analysis was performed uncover therapeutic implicated...
Abstract The majority of advanced breast cancers exhibit strong aggressiveness, heterogeneity, and drug resistance, currently, the lack effective treatment strategies is one main challenges that cancer research must face. Therefore, developing a feasible preclinical model to explore tailored treatments for refractory urgently needed. We established organoid biobanks from 17 patients with characterized them by immunohistochemistry (IHC) next generation sequencing (NGS). In addition, we in...
Accumulated evidence indicates that aberrant microRNAs (miRNAs) expression plays an important role in the initiation and progression of various cancers, including breast cancer. Previous studies suggested miR‑139‑3p might serve as a tumor suppressor is downregulated several cancer types. However, patterns exact remain to be elucidated. In this study, we aimed analyze effect on mechanism involved. Through bioinformatics analysis vitro experimental studies, found was decreased tissues cell...
Breast cancer (BC) is the most common malignant in women worldwide. Recently, long non-coding RNAs (LncRNAs) have been reported to essential roles BC tumorigenesis. Tumor and adjacent non-tumor tissue samples were collected from patients with (n = 168) for comparison of LncRNA miRNA expression levels. Patient clinical, demographic, molecular data analyzed by univariate multivariate methods identify factors associated patient survival, a nomogram was generated using significant...
To further enhance anticancer effect of Shepherdin and overcome limitation peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic secretory expression gene transfer system. MTT assay flow cytometric analysis revealed that rAAV harboring fusion NT4-Ant-Shepherdin significantly suppressed A549 cell growth in a time-dependent manner induced apoptosis. In the infected cells, survivin level decreased strongly while Caspase-3/7 activities...
Abstract Background The benefit of axillary lymph node dissection (ALND) in breast cancer patients with one or two positive sentinel nodes (SLNs) remains inconclusive. purpose this study was to identify risk factors independently associated (ALN) metastasis. Methods We retrospectively analyzed data from 389 Chinese SLNs who underwent ALND. Univariate and multivariate logistic regression analyses were performed ALN metastasis-associated factors. Results Among the patients, 174 (44.7%) had...
This paper mainly experimentally studies the imidacloprid degradation in an atmospheric dielectric barrier discharge (DBD) plasma.The effects of DBD parameters, temperature and initial concentration on ratio were investigated with help high-performance liquid chromatography (HPLC).The analyses HPLC-MS (mass spectrometry) comparison database proved that after plasma treatment four new products generated.It shows can effectively degrade effect depends as well voltage time.Under proper be up to...
Abstract As an aggressive breast cancer (BCa) subtype, triple‐negative (TNBC) responses poorly to chemotherapy and endocrine therapy, usually has a worse prognosis. This is largely due the lack of specific therapeutic targets, laying claim imperious demand clarify key signaling pathways potentiating TNBC progression. Herein, we report that expression levels liver‐specific bHLH‐Zip transcription factor (LISCH7), recently identified player in cancerous progression, preferentially enriched...
Abstract Background: An emerging novel liquid biopsy technology called Cancer Differentiation Analysis (CDA) has been evaluated as a viable early stage breast cancer screening tool. CDA is blood-sample based, multi-level, multi-parameter diagnostic method which detects signals from both protein, cellular, and to some extent, molecular levels, in multiple aspects of information can be collected improve accuracy, even for cancer. Improving capability screen an important on-going research...