A5038316847- Hearing, Cochlea, Tinnitus, Genetics
- Urinary Bladder and Prostate Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Urological Disorders and Treatments
- Transplantation: Methods and Outcomes
- Retinal and Optic Conditions
- SARS-CoV-2 and COVID-19 Research
- Ear Surgery and Otitis Media
- Plant and Fungal Interactions Research
- Congenital gastrointestinal and neural anomalies
- SARS-CoV-2 detection and testing
- Anesthesia and Pain Management
- EEG and Brain-Computer Interfaces
- Asthma and respiratory diseases
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Plant Virus Research Studies
- Nitric Oxide and Endothelin Effects
- Motor Control and Adaptation
- Pelvic floor disorders treatments
- Mechanical Circulatory Support Devices
- Advancements in Transdermal Drug Delivery
- Genomic variations and chromosomal abnormalities
Columbia University Irving Medical Center
2019-2025
Chinese University of Hong Kong
1988-2025
Prince of Wales Hospital
2020-2025
Texas Health Dallas
2023-2025
Columbia University
2011-2024
University of Saskatchewan
2024
Saskatchewan Cancer Agency
2024
Reading Hospital
2024
Presbyterian Hospital
2023
NewYork–Presbyterian Hospital
2023
Background Increasing epidemiological studies reported that overweight/obese asthma patients had more frequent and severe symptoms exacerbations, indicating their management may not be sufficient. Airway hyperresponsiveness (AHR), a significant feature of asthma, was found to link with the body mass index (BMI) mixed findings using "direct" methacholine challenge test. The objective examine association between BMI control, as reflected by "indirect" AHR mannitol test in paediatric asthmatic...
Background and Purpose: Essential Tremor (ET) is among the most prevalent neurologic disorders. Growing clinical neuro‐imaging evidence implicates cerebellar dysfunction in pathogenesis of ET emerging postmortem studies have identified structural changes cerebellum, particularly Purkinje cells. In this study we systematically quantified focal cell dendritic swellings (DS) 20 vs. 19 control brains. Methods: each brain, a standard parasagittal neocerebellar tissue block was harvested. DS were...
SARS-CoV-2 enters the body through inhalation or self-inoculation to mucosal surfaces. The kinetics of ocular and nasal mucosal-specific-immunoglobulin A(IgA) responses remain under-studied.Conjunctival fluid (CF, n = 140) epithelial lining (NELF, 424) obtained by paper strips plasma (n 153) were collected longitudinally from paediatric 34) adult 47) patients. spike protein 1(S1)-specific antibody levels in COVID-19 patients, hospital admission six months post-diagnosis, assessed.The was...
Hypothesis: Three-dimensional (3D)-printed microneedles can create precise holes on the scale of micrometers in human round window membrane (HRWM). Background: An intact is a barrier to delivery therapeutic and diagnostic agents into inner ear. Microperforation guinea pig has been shown overcome this by enhancing diffusion 35-fold. In humans, challenge design microneedle that precisely perforate thicker HRWM without damage. Methods: Based thickness mechanical properties HRWM, two designs...
Microneedles can create microperforations in the round window membrane (RWM) without causing anatomic or physiologic damage.Reliable delivery of agents into inner ear for therapeutic and diagnostic purposes remains a challenge. Our novel approach employs microneedles to facilitate intracochlear access via RWM. This study investigates anatomical functional consequences microneedle perforations guinea pig RWMs vivo.Single three-dimensional-printed, 100 μm diameter were used perforate RWM...
The variational method, as the core tool of functional extremum analysis, has a wide and profound impact on mathematical theory engineering applications through its three basic operations - chain rule, partial integration, variable substitution. This article systematically reviews historical development these methods their key roles in classical mechanics differential equations. research results indicate that rule provides an effective approach for variation complex functionals by handling...
Abstract Detection of copy number variations (CNVs) is essential for uncovering genetic factors underlying human diseases. However, CNV detection by current methods prone to error, and precisely identifying CNVs from paired-end whole genome sequencing (WGS) data still challenging. Here, we present a framework, CNV-JACG, Judging the Accuracy Genotyping using WGS data. CNV-JACG based on random forest model trained 21 distinctive features characterizing region its breakpoints. Using 1000...
A new scheme for 3D reconstruction of implicit surfaces from large scattered point sets based on the radial basis functions (RBFs) is proposed in this paper. The partition unity (POU) method and a binary tree used to organize into some overlapping local subdomains reconstructing surface each non-disjunct subsets points, we use only single at offset avoid trivial solution RBF linear system. When chosen properly, technique not efficient but also robust, offering higher level scalability....
The involvement of ionotropic glutamate receptors in bladder overactivity and pudendal neuromodulation was determined <i>α</i>-chloralose anesthetized cats by intravenously administering MK801 (a NMDA receptor antagonist) or CP465022 (an AMPA antagonist). Infusion 0.5% acetic acid (AA) into the produced overactivity. In first group 5 cats, capacity significantly (<i>P</i> < 0.05) reduced to 55.3±10.0% saline control AA irritation. Pudendal nerve stimulation (PNS) increased 106.8 ± 15.0%...
This study in α-chloralose-anesthetized cats discovered an excitatory peroneal nerve-to-bladder reflex. A urethral catheter was used to infuse the bladder with saline and record pressure changes. Electrical stimulation applied superficial nerve trigger reflex activity. With distended at a volume ~90% of capacity, (PNS) 1-3 Hz threshold (T) intensity for inducing muscle twitching on posterior thigh induced large-amplitude (40-150 cmH2O) contractions. PNS (1-3 Hz, 1-2T) during cystometrograms...
This study tested the hypothesis that sacral neuromodulation, i.e., electrical stimulation of afferent axons in spinal root, can block pudendal inhibition micturition reflex. In α-chloralose-anesthetized cats, nerve (PNS) at 3-5 Hz was used to inhibit bladder reflex activity while S1 or S2 dorsal root stimulated 15-30 mimic neuromodulation and induced by PNS. The intensity threshold (T) for PNS S1/S2 (DRS) induce muscle twitch anal sphincter toe determined. 1.5-2T inhibited significantly ( P...
Social media has an ever-growing presence in patients' lives, particularly with the dissemination of both useful and misleading information. We performed exploration analysis content pertaining to cochlear implantation on a popular social platform."Cochlear implant" (CI) was queried TikTok early October 2022 cross-sectional analysis. The 100 top videos were collected. Non-English duplicate excluded. Two independent researchers used Global Quality Scale (GQS) modified DISCERN tool score...
Microneedle-mediated intracochlear injection of siRNA-Lipofectamine through the round window membrane (RWM) can be used to transfect cells within cochlea.
The cloaca is an embryonic cavity that divided into the urogenital sinus and rectum upon differentiation of cloacal epithelium triggered by tissue-specific transcription factors including CDX2. Defective leads to persistent in humans (PC), a phenotype recapitulated Cdx2 mutant mice. PC linked hypo/hyper-vitaminosis A. Although no gene has ever been identified, there strong evidence for genetic contribution PC. We applied whole-exome sequencing copy-number-variants analyses 21 patients their...
Abstract Background and Objective Bronchiolitis obliterans (BO) is a rare but serious condition. The natural history outcomes remain poorly understood. In this clinical review, we aimed to describe the characteristics of children diagnosed with BO in Hong Kong (HK). Methods This was retrospective study pediatric patients under care six respiratory units HK from January 1996 December 2015. Information retrieved medical records. Results Fifty‐six were included male predominance (67.9%). median...
Haptics combined with functional magnetic resonance imaging (Haptic fMRI) can non-invasively study how the human brain coordinates movement during complex manipulation tasks, yet avoiding associated fMRI artifacts remains a challenge. Here, we demonstrate confound-free neural activation measurements using Haptic for an unconstrained three degree-of-freedom motor task that involves planning, reaching, and visually guided trajectory tracking. Our haptic interface tracked subjects' hand...
The role of cannabinoid type 1 (CB1) receptors in tibial and pudendal neuromodulation bladder overactivity induced by intravesical infusion 0.5% acetic acid (AA) was determined α-chloralose anesthetized cats. AA irritation significantly ( P < 0.01) reduced capacity to 36.6 ± 4.8% saline control capacity. Tibial nerve stimulation (TNS) at two or four times threshold (2T 4T) intensity for inducing toe movement inhibited increased 69.2 9.7 79.5 7.2% control, respectively. AM 251 (a CB1...