A5100599244- Body Composition Measurement Techniques
- Thermoregulation and physiological responses
- Diagnosis and Treatment of Venous Diseases
- Healthcare and Venom Research
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Entomological Studies and Ecology
- Nutrition and Health in Aging
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Sports injuries and prevention
- Skin Protection and Aging
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Metabolism, Diabetes, and Cancer
- Parkinson's Disease Mechanisms and Treatments
- Biotechnology and Related Fields
- Diet and metabolism studies
- Tryptophan and brain disorders
- Circular RNAs in diseases
- Intracranial Aneurysms: Treatment and Complications
- RNA Research and Splicing
- Textile materials and evaluations
- Eicosanoids and Hypertension Pharmacology
- Sports Performance and Training
Southern Medical University
2014-2025
Songjiang District Central Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Kunming Medical University
2023
University of Southampton
2012-2022
North University of China
2021
South Australian Health and Medical Research Institute
2016-2021
The University of Adelaide
2016-2020
University of Science and Technology Beijing
2020
Ningxia Center for Diseases Prevention and Control
2019
// Pan Jiang 1 , Xiaoyue Wu Xuemin Wang 2 Wenbin Huang 3 Qing Feng Department of Nutrition and Food Hygiene, Key Laboratory Toxicology, School Public Health, Nanjing Medical University, Nanjing, China Beijing Research Institute for Nutritional Resources, Beijing, Pathology, Affiliated First Hospital Correspondence to: Feng, email: qingfeng@njmu.edu.cn Keywords: cisplatin, lung cancer, hsa-mir-98-5p, CTR1, NEAT1 Received: February 02, 2016 Accepted: May 12,...
Abstract Aim Patients with diabetes mellitus have poor prognosis after myocardial ischemic injury. However, the mechanism is unclear and there are no related therapies. We aimed to identify regulators of diabetic Methods results Mass spectrometry-based, non-targeted metabolomic approach was used profile coronary sinus blood from non-diabetic Bama-mini pigs at 0.5-h post artery ligation. Six metabolites had a |log 2 (Fold Change)|> 1.3. Among them, most changed arachidonic acid (AA),...
Mitochondria play a central role in cell biological processes, functioning not only as producers of ATP but also regulators Ca2+ signaling. Mitochondrial calcium uptake occurs primarily through the mitochondrial uniporter channel (mtCU), with subunits 1, 2, and 3 (MICU1, MICU2, MICU3) serving main regulatory components. Dysregulated is hallmark cellular degeneration. Sirtuin 1 (SIRT1), key regulator metabolism, plays critical aging various neurodegenerative conditions. By blocking SIRT1...
Protein synthesis, especially translation elongation, requires large amounts of energy, which is often generated by oxidative metabolism. Elongation controlled phosphorylation eukaryotic elongation factor 2 (eEF2), inhibits its activity and catalyzed eEF2 kinase (eEF2K), a calcium/calmodulin-dependent α-kinase. Hypoxia causes the activation eEF2K induces independently previously known inputs into eEF2K. Here, we show that subject to hydroxylation on proline-98. Proline proline hydroxylases,...
The class IIa histone deacetylases (HDACs) play important roles in the central nervous system during diverse biological processes such as synaptic plasticity, axon regeneration, cell apoptosis, and neural differentiation. Although it is known that HDAC5 regulates neuronal differentiation, neither physiological function nor regulation of differentiation clear. Here, we identify an inhibitor neurite elongation show regulated by brain enriched microRNA miR‐124 miR‐9. We discover inhibits...
Abstract Retinal vasculature analysis is important for the early diagnostics of various eye and systemic diseases, making it a potentially useful biomarker, especially resource-limited regions countries. Here we developed smartphone-based retinal image system point-of-care that able to load fundus image, segment vessels, analyze individual vessel width, store or uplink results. The proposed was not only evaluated on widely used public databases compared with state-of-the-art methods, but...
Activating mutations in KRAS frequently occur colorectal cancer (CRC) patients, leading to resistance EGFR-targeted therapies. To better understand the cellular reprogramming which occurs mutant cells, we have undertaken a systems-level analysis of four CRC cell lines express either wild type (wt) or oncogenic KRASG13D allele (mtKRAS). RNAseq revealed that genes involved ribosome biogenesis, mRNA translation and metabolism were significantly upregulated mtKRAS cells. Consistent with...
Eukaryotic elongation factor 2 kinase (eEF2K) inhibits the stage of protein synthesis by phosphorylating its only known substrate, eEF2. eEF2K is tightly regulated nutrient-sensitive signalling pathways. For example, it inhibited through mammalian target rapamycin complex 1 (mTORC1). It therefore activated under conditions nutrient deficiency. Here we show that inhibiting or knocking down expression renders cancer cells sensitive to death nutrient-starved conditions, and this rescued...
We have previously shown that the vasoconstrictive peptide angiotensin II (ANG II) is a hypertrophic agent for human coronary artery smooth muscle cells (cSMCs), which suggests it plays role in vascular wall thickening. The present study investigated intracellular signal transduction pathways involved growth response of cSMCs to ANG II. stimulation protein synthesis by was blocked immunosuppressant rapamycin, an inhibitor mammalian target rapamycin (mTOR) signaling pathway includes 70-kDa S6...
Diet-driven obesity is increasingly widespread. Its consequences pose major challenges to human health and care systems. There are MAP kinase-interacting kinases (MNKs) in mice, MNK1 MNK2. Studies have demonstrated that mice lacking either or MNK2 were partially protected against high-fat diet (HFD)-induced weight gain insulin resistance. The aims of this study evaluate the phenotype both MNKs when given an HFD, assess whether pharmacological inhibition MNK function also protects...
Abstract Background Tranexamic acid ( TA ) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become topic lot research. The aim this study to determine whether could repair barrier by means tight intercellular junctions. Methods Two kinds models were set up subjected repeated application sodium lauryl sulfate irradiation ultraviolet B . Through bioengineering technology immunohistochemistry tests, ‐induced changes detected. Results After 1, 3, 7, 14 days...
Among clinical and morphological criteria, hemodynamics is the main predictor of aneurysm growth rupture. This study aimed to identify which hemodynamic parameter in parent artery could independently predict rupture anterior communicating (ACoA) aneurysms by using multivariate logistic regression two-piecewise linear models. An additional objective was look for a more simplified convenient alternative widely used computational fluid dynamics (CFD) techniques detect wall shear stress (WSS) as...
Peroxisome proliferator-activated receptor γ (PPARγ) serves an essential protective function in neurons. Although PPARγ activation is known to reduce brain tissue damage distinct models of diseases, the regulation activity neurons unclear. Here, we report that histone deacetylase 4 (HDAC4) mediates inhibition cultured cortical under oxidative stress. Our data indicate HDAC4 physically interacts with and represses transcription Upon H(2) O(2) treatment, translocates from cytoplasm nucleus,...
Parkinson's disease (PD) is one of the most prevalent and life-threatening neurodegenerative mainly characterized by lack sufficient dopaminergic neurons in substantia nigra pars compacta (SNc). Although current treatments help to alleviate clinical symptoms, effective therapies preventing neuronal loss remain scarce. Tovophyllin A (TA), xanthones extracted from Garcinia mangostana L. (GM), has recently been reported play a beneficial role therapy diseases. In our research, we explored...