A5085744778- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Bioinformatics and Genomic Networks
- Immune responses and vaccinations
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Advanced Proteomics Techniques and Applications
- Prostate Cancer Treatment and Research
- Long-Term Effects of COVID-19
- vaccines and immunoinformatics approaches
- COVID-19 Clinical Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Vaccine Coverage and Hesitancy
- Biomedical Text Mining and Ontologies
- Mass Spectrometry Techniques and Applications
- MicroRNA in disease regulation
- Animal Genetics and Reproduction
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Cancer, Hypoxia, and Metabolism
- RNA and protein synthesis mechanisms
Flinders University
2016-2025
South Australian Health and Medical Research Institute
2016-2025
Flinders Medical Centre
2017-2025
The University of Adelaide
2025
EMBL Australia
2015-2020
University of Colorado Anschutz Medical Campus
2017
University of Colorado Denver
2017
Teagasc - The Irish Agriculture and Food Development Authority
2010-2016
University College Dublin
2003-2016
Simon Fraser University
2007-2015
To understand the biology and evolution of ruminants, cattle genome was sequenced to about sevenfold coverage. The contains a minimum 22,000 genes, with core set 14,345 orthologs shared among seven mammalian species which 1217 are absent or undetected in noneutherian (marsupial monotreme) genomes. Cattle-specific evolutionary breakpoint regions chromosomes have higher density segmental duplications, enrichment repetitive elements, species-specific variations genes associated lactation immune...
InnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes. In this article, we provide details recent updates improvements the database. now contains >196 000 human, mouse bovine experimentally validated molecular interactions 3000 pathway annotations relevance all cellular systems (i.e. not just immune relevant interactions). addition, team has,...
A survey of genetic diversity cattle suggests two domestication events in Asia and selection by husbandry.
Article2 September 2008Open Access InnateDB: facilitating systems-level analyses of the mammalian innate immune response David J Lynn Corresponding Author Department Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada Centre for Microbial Diseases Immunity Research, University Vancouver, Search more papers by this author Geoffrey L Winsor Calvin Chan Nicolas Richard Matthew R Laird Aaron Barsky Computer Science, Jennifer Gardy Fiona M Roche Timothy...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious virus which responsible for the disease 2019 (COVID-19) pandemic. It increasingly clear that recovered individuals, even those who had mild COVID-19, can suffer from persistent symptoms many months after infection, condition referred to as "long COVID", post-acute sequelae of COVID-19 (PASC), syndrome, or post condition. However, despite plethora research on relatively little known about molecular...
Abstract The current wealth of genomic variation data identified at nucleotide level presents the challenge understanding by which mechanisms amino acid affects cellular processes. These effects may manifest as distinct phenotypic differences between individuals or result in development disease. Physical interactions molecules are linking steps underlying most, if not all, Understanding that sequence has on a molecule’s is key step towards connecting mechanistic characterization...
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate efficacy of targeting FAO clinical tumors cultured ex vivo, identify DECR1, encoding rate-limiting enzyme for oxidation polyunsaturated fatty acids (PUFAs), as robustly overexpressed PCa tissues associated with shorter relapse-free survival. DECR1 negatively-regulated androgen receptor (AR) target gene and, therefore, may promote...
Accumulating evidence indicates that antibiotic exposure may lead to impaired vaccine responses1-4; however, the mechanisms underlying this association remain poorly understood. Here we prospectively followed 191 healthy, vaginally born, term infants from birth 15 months, using a systems vaccinology approach assess effects of on immune responses vaccination. Exposure direct neonatal but not intrapartum antibiotics was associated with significantly lower antibody titres against various...
The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes.Using publicly available proteome mammary expressed tags, 197 protein genes over 6,000 were identified in genome. Intersection these 238 production quantitative trait loci curated from literature decreased search space for effectors by more than an order magnitude. Genome location analysis revealed a tendency to be clustered genes. Using genomes monotreme...
Abstract Background: Team learning, an innovative educational method combining interactive small group learning with expert-based content delivery, was introduced into our psychiatry clerkship in 2002. The main goal to increase classroom engagement and improve outcomes. Description: Eight of 16 lectures were replaced team activities, including prerequisite readings, readiness assurance tests, application exercises. Data on students' performance experiences compared before after curricular...
ABSTRACT Toll-like receptors (TLRs) are a group of highly conserved molecules that initiate the innate immune response to pathogens by recognizing structural motifs expressed microbes. We have identified novel TLR, TLR15, bioinformatic analysis chicken genome, which is distinct from any known vertebrate TLR and thus appears be avian specific. The gene for TLR15 was sequenced found on chromosome 3, it has archetypal TIR transmembrane domains distinctive arrangement extracellular leucine-rich...
Abstract Background Contemporary dairy breeding goals have broadened to include, along with milk production traits, a number of non-production-related traits in an effort improve the overall functionality cow. Increased indirect selection for resistance mastitis, one most important production-related diseases sector, via reduced somatic cell count has been part these goals. A genome-wide association studies identified genetic variants associated and mastitis resistance, however majority...
: The ability to experimentally determine molecular interactions on an almost proteome-wide scale under different conditions is enabling researchers move from static dynamic network analysis, uncovering new insights into how interaction networks are physically rewired in response stimuli and disease. Dynamic data presents a special challenge biology. Here, we present DyNet, Cytoscape application that provides range of functionalities for the visualization, real-time synchronization analysis...
Understanding how human neonates respond to infection remains incomplete. Here, a system-level investigation of neonatal systemic responses shows surprisingly strong but unbalanced homeostatic immune response; developing an elevated set-point myeloid regulatory signalling and sugar-lipid metabolism with concomitant inhibition lymphoid responses. Innate immune-negative feedback opposes innate activation while suppression T-cell co-stimulation is coincident selective upregulation CD85...
ABSTRACT Dengue is a pantropic public health problem. In children, dengue shock syndrome (DSS) the most common life-threatening complication. The ability to predict which patients may develop DSS improve triage and treatment. To this end, we conducted nested case-control comparison of early host transcriptional features in 24 56 sex-, age-, virus serotype-matched uncomplicated (UC) patients. first instance, defined “early dengue” profile. signature acute rather than convalescent samples (≤72...
Abstract Background The liver is central to most economically important metabolic processes in cattle. However, the changes expression of genes that drive these remain incompletely characterised. RNA-seq new gold standard for whole transcriptome analysis but so far there are no reports its application differential gene cattle liver. We used study differences profiles hepatic and their associated pathways individual either mild negative energy balance (MNEB) or severe (SNEB). NEB an imbalance...