A5044903596- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Animal Genetics and Reproduction
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Genomics and Phylogenetic Studies
- Chromosomal and Genetic Variations
- Molecular Biology Techniques and Applications
- Genetic diversity and population structure
- Animal Behavior and Welfare Studies
- Reproductive Physiology in Livestock
- Infectious Diseases and Mycology
- T-cell and B-cell Immunology
- Myxozoan Parasites in Aquatic Species
- Nutrition, Genetics, and Disease
- melanin and skin pigmentation
- Lipid metabolism and biosynthesis
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Genomic variations and chromosomal abnormalities
- Literature: history, themes, analysis
- Evolution and Paleontology Studies
- Wheat and Barley Genetics and Pathology
Texas A&M University
2014-2025
University of South Africa
2024-2025
Mitchell Institute
2014-2024
Washington State University
1999-2021
National Animal Disease Center
2019
Animal Science Research Institute
2009
Texas A&M University System
2007
University of South Florida
2006
The University of Adelaide
1999-2001
A survey of genetic diversity cattle suggests two domestication events in Asia and selection by husbandry.
Abstract Background Bovine whole genome linkage disequilibrium maps were constructed for eight breeds of cattle. These data provide fundamental information concerning bovine organization which will allow the design studies to associate genetic variation with economically important traits and also provides background extent long range in Results Linkage was assessed using r 2 among all pairs syntenic markers within cattle from Bos taurus indicus subspecies. included Angus, Charolais, Dutch...
Associations between 3 commercially available genetic marker panels (GeneSTAR Quality Grade, GeneSTAR Tenderness, and Igenity Tender-GENE) quantitative beef traits were validated by the US National Beef Cattle Evaluation Consortium. Validation was interpreted to be independent confirmation of associations tests phenotypes, as claimed commercial genotyping companies. quality grade test Grade) carried out on 400 Charolais x Angus crossbred cattle, validation tenderness Tenderness over 1,000...
Fat composition of beef, taken here to mean marbling, can be manipulated by time on feed, finishing diet, and breed type.These three factors also strongly influence the fatty acid beef.Both amount marbling concentration monounsaturated acids (MUFA) increase with feed in grain-fed pasture-fed cattle, but much more dramatically cattle.High-concentrate diets stimulate activity adipose tissue stearoyl-CoA desaturase (SCD), which is responsible for conversion saturated (SFA) their Δ9 desaturated...
The Bovine HapMap Consortium has generated assay panels to genotype ~30,000 single nucleotide polymorphisms (SNPs) from 501 animals sampled 19 worldwide taurine and indicine breeds, plus two outgroup species (Anoa Water Buffalo). Within the larger set of SNPs we targeted 101 high density regions spanning up 7.6 Mb with an average approximately one SNP per 4 kb, characterized linkage disequilibrium (LD) haplotype block structure within individual breeds groups in relation their geographic...
Abstract Background Analyses of population structure and breed diversity have provided insight into the origin evolution cattle. Previously, these studies used a low density microsatellite markers, however, with large number single nucleotide polymorphism markers that are now available, it is possible to perform genome wide genetic analyses in In this study, we high-density panel SNP examine among eight cattle breeds sampled from Bos indicus taurus . Results Two thousand six hundred forty...
Toll-like receptor 4 (TLR4) is a cell-surface that activates innate and adaptive immune responses. Because it recognizes broad class of pathogen-associated molecular patterns presented by lipopolysaccharides lipoteichoic acid, TLR4 candidate gene for resistance to large number diseases. In particular, mouse models suggest as major agents in bovine respiratory disease Johne's disease. The coding sequence divided into three exons, with intron/exon boundaries intron sizes similar those human...
Carcass and Warner-Bratzler shear force (WBSF) data from strip loin steaks were obtained 7,179 progeny of Angus, Brahman, Brangus, Charolais, Gelbvieh, Hereford, Limousin, Maine-Anjou, Red Salers, Shorthorn, Simbrah, Simmental, South Devon sires. Trained sensory panel (TSP) evaluations on 2,320 sampled contemporary groups one to five sires each breed. Expected differences for marbling WBSF developed 103 Simmental 1,295 progeny, 23 Shorthorn 310 69 Hereford 1,457 progeny. Pooled phenotypic...
Cattle are important agriculturally and relevant as a model organism. Previously described genetic radiation hybrid (RH) maps of the bovine genome have been used to identify genomic regions genes affecting specific traits. Application these influential polymorphisms will be enhanced by integration with each other bacterial artificial chromosome (BAC) libraries. The BAC libraries clone essential for clone-by-clone/whole-genome shotgun sequencing approach taken project. A map was constructed...
Genomics encompasses the entire tree of life, both extinct and extant, evolutionary processes that shape this diversity. To date, genomic research has focused on humans, a small number agricultural species, established laboratory models. Fewer than 18,000 ∼2,000,000 eukaryotic species (<1%) have representative genome sequence in GenBank, only fraction these ancillary information structure, genetic variation, gene expression, epigenetic modifications, population This imbalance reflects...
Herein, transcription factor NF-κB is characterized from two model jellyfish, Aurelia aurita (Aa) and Clytia hemisphaerica (Ch). Both jellyfish proteins consist primarily of the N-terminal DNA-binding/dimerization domain, they lack C-terminal ankyrin repeat inhibitory domain found in vertebrate proteins. can bind to a consensus mammalian binding site, their AlphaFold3-predicted structures on DNA are similar that mouse p50. Neither Aa- nor Ch-NF-κB activated an NF-κB-site reporter gene human...
<title>Abstract</title> The genetic heterogeneity of autism spectrum disorder (ASD) presents significant challenges in understanding its pathogenic mechanisms, as the risk involves numerous common variants and rare <italic>de novo</italic> or inherited variants. Prior research has mainly focused on identifying their impact neurodevelopment neuronal functions cortical brain regions. By contrast, variants, which contribute substantially to ASD heritability, remain understudied, suggesting a...
Abstract Background In cattle, base color is assumed to depend on the enzymatic activity specified by MC1R locus, i.e. extension with alleles coding for black ( E D ), red e and wild-type + ). most mammals, these are presumed follow dominance model of > , although exceptions found. Bos indicus x taurus F 2 some heterozygotes discordant series display various degrees pigmentation an otherwise predicted background. The objective this study was identify loci that modify coat in individuals....
The role of genetic relatedness in the evolution eusociality has been topic much debate, especially when contrasting eusocial insects with vertebrates displaying reproductive altruism. naked mole-rat, Heterocephalus glaber, was first described mammal. Although this discovery based on an ecological constraints model evolution, early studies reported high levels mole-rats, providing a compelling argument that low dispersal rates and consanguineous mating (inbreeding as system) are driving...
Abstract The 39th International Society for Animal Genetics conference (ISAG) was held the first time in Africa under theme ‘Animal genetics a sustainable future’ 2023. convened scientists, policy makers, industry professionals, and students from interdisciplinary fields to share discuss latest developments space of animal genetics. Since its inception as society, ISAG has sought provide platform advocating just equitable future At conference, this commitment towards furthering inclusion...
Acetyl-CoA carboxylase-α (ACC-α) plays a central role in co-ordinating de novo fatty acid synthesis animal tissues. We have characterized the regulatory region of ovine ACC-α gene. Three promoters, PI, PII and PIII, are dispersed throughout 50kb genomic DNA. Expression from PI is limited to adipose tissue liver. Sequence comparison proximal promoters mouse PIs demonstrates high nucleotide identity that they by TATA box at −29, C/EBP (CCAAT enhancer-binding protein)-binding motifs multiple...
Summary High‐density whole‐genome maps are essential for ordering genes or markers and aid in the assembly of genome sequence. To increase density on bovine radiation hybrid map, hence contribute to sequence, an Illumina ® BeadStation was used simultaneously type large numbers Roslin‐Cambridge 3000 rad bovine–hamster panel (WGRH ). In five multiplex reactions, 6738 sequence tagged site (STS) were successfully typed WGRH DNA. These STSs harboured SNPs that developed as a result sequencing...
Dysregulation of adipogenesis causes metabolic diseases, like obesity and fatty liver. Migratory birds such as geese have a high tolerance massive energy intake exhibit little pathological development. Domesticated goose breeds, derivatives the wild greyleg (Anser anser) or swan cygnoides), resembling their ancestor species. Thus, is potentially model species to study mechanisms associated with adipogenesis.Phenotypically, liver exhibited higher fat accumulation than adipose tissues during...
Genes within the major histocompatibility complex (MHC) encode proteins involved in innate and adaptive immune responses. Genetic variation this region can influence response of an individual animal to challenges from a variety pathogens; however, complete documentation genetic MHC is lacking for most domestic animals, including horses. To provide additional markers study horse MHC, or ELA (equine lymphocyte antigen), we identified 37 polymorphic microsatellite repeats used these variations...
The size, support, and health of udders limit the productive life beef cows, especially those with background, because, in general, such cows have a reputation for problems udders. Genomic association studies bovine udder traits been conducted dairy cattle recently Continental European breeds but not background. objective this study was to determine associations SNP support scores, teat length, diameter half (Nellore), (Angus) cows. Udders ( = 295) born from 2003 2007 were evaluated length...
ABSTRACT Ovine pulmonary adenocarcinoma (OPA) is an infectious lung tumor of sheep caused by Jaagsiekte retrovirus (JSRV). To test the hypothesis that JSRV insertional mutagenesis involved in oncogenesis OPA, we cloned and characterized 70 independent integration sites from 23 cases OPA. Multiple were identified most tumors. BLAST analysis sequences did not disclose any potential oncogenic motifs or identical different Thirty-seven mapped to individual chromosomes PCR with a panel...