Dandruff is an unpleasant scalp disorder common to human populations. In this study, we systematically investigated the intra- and inter-associations among dandruff, physiological conditions such as sebum of scalp, host demographics gender, age region microorganisms on scalp. We found that were highly relevant varied in different regions same The quantity water content negatively correlated with formation dandruff had significant relationships two dominant but reciprocally inhibited bacteria...

Abstract Objective To evaluate the impact of oral intake Hyaluronic Acid (HA) on skin health. Background HA, an endogenous substance in human body, plays a key role However, its concentration decreases significantly with age. Previous studies suggested that HA can supplement body's level, but did not reveal effects different age groups and types. Methods A double‐blind, randomized clinical trial 129 female participants, covering young elderly differnet types, was conducted to assess efficacy...

Abstract Background Tranexamic acid ( TA ) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become topic lot research. The aim this study to determine whether could repair barrier by means tight intercellular junctions. Methods Two kinds models were set up subjected repeated application sodium lauryl sulfate irradiation ultraviolet B . Through bioengineering technology immunohistochemistry tests, ‐induced changes detected. Results After 1, 3, 7, 14 days...

This study evaluated cutaneous microbial distribution, and co-occurrence at different body sites skin environments in Chinese women (39.6 ± 11.9 years, N = 100) during the winter season. Microbial distribution (Propionibacterium acnes, Staphylococcus aureus, epidermidis, Lactobacillus, Pseudomonadaceae, Malassezia furfur), association with biomarkers (antimicrobial peptides: LL-37, β-defensins [HBD-2, HBD-3]), claudin-1) biophysical parameters (transepidermal water loss, pH, scaliness...

Nowadays, the diagnosis for sensitive skin relies on subjective assessment or combination of and objective evaluation. No quantitative evaluation is available. It could be expected that confocal microscopy imaging interest to better define condition.Total 166 healthy female subjects were recruited in this study. Firstly, all completed questionnaire. Then, cutaneous structures measured by reflectance (RCM) face fossa cubitalia. The lactic acid sting test was conducted finally. According...

The skin microbiota barrier participates in function addition to the physical, chemical, and immunological protective barriers, is affected by environmental aggressors skincare regimens. To better understand exact effects of real-life conditions on determine methods, this study investigates three topical cosmetic moisturizers (water gel with/without yeast extract (Moisturizers K C) a thick-emulsion cream moisturizer (Moisturizer L)) clinical microbiome endpoints presence during an 8-week,...

Abstract Background Rosacea is a common condition characterized by transient or persistent central facial erythema, and often papules pustules. Currently, the role of bacterium in development progression rosacea remains controversial. This study aimed to investigate difference physiological conditions microorganisms between lesional non‐lesional areas papulopustular rosacea. Methods Twenty‐five French patients with were enrolled this pilot study. Each patient was subjected clinical...

Background . Diaper rash, also known as diaper dermatitis (DD), is a very common skin condition in infants, and use of disposable diapers with breathable materials an effective approach for the management rash. In China, new material standard are currently two most commonly used diapers. This study aimed to compare effectiveness versus prevention rash Chinese babies. Methods A total 80 eligible babies admitted Shanghai Skin Diseases Hospital during period from June through July, 2016, were...

Erythema induced by ultraviolet (UV)B light is a common skin reaction. Currently, three techniques, the Chromameter(®) CR-400, Mexameter(®) MX16 and full-field laser perfusion imaging (FLPI), are widely used for dermatological evaluation of UVB-induced erythema. However, there little known about comparative performance these techniques. This study was therefore designed to evaluate effectiveness Our findings showed that Chromameter Mexameter measurement erythema very similar, while FLPI...

The properties of infant skin regarding its structure and stratum corneum (SC) during development compared to adult have been reported only for a few races body sites. aim this study was understand the developmental changes in Chinese infants, focusing on SC ceramides protein secondary structure, which are important barrier function. Three sites with distinct characteristics (cheeks, inner upper arms, buttocks) were assessed. Sixty pairs infants their mothers measured hydration,...

Intense pulsed light (IPL) is a good option for erythema and telangiectasia of rosacea. Demodex, which heat sensitive, an important risk Rosacea. Sometimes, IPL can induce rosacea aggravation. Here, we show two cases aggravated as pustule in several hours after IPL. Both high density Demodex Neither them had photosensitivity, systemic disease, or any other contraindication One the patients received again infection relieved this time there was no inflammation induction. We need to attract...

In the rosacea an unstable skin microbiota is significant for disease progression. However, data on influence of treatment with systemic antibiotics are limited. This single-arm trial recruited patients rosacea. Oral minocycline 50 mg was administered twice daily 6 weeks. The lesions cheek and nose were sampled 16S rRNA amplicon sequencing metagenomic at baseline, 3 weeks treatment. Physiological parameters detected using non-invasive instruments. After treatment, distribution Investigator...

To observe the alteration ultraviolet radiation (UVR) of skin's tolerance after its exposure to small dose UVR under protection sunscreen.Eleven subjects who applied sunscreen were exposed 0.75 minimal persistent pigment darkening (MPPD) and erythema (MED) by Phototherapy Unit for 4 weeks. Each week their MPPDs MEDs measured solar simulator. Meanwhile, SPECTCOLOMETER® VISIOSCAN VC98® used detect test areas control areas.The values MPPD MED increased significantly UVR. But there no visible...

Objective: This study was to verify if the skin cleanser could help decrease infection ratio of Demodex Folliculorum in acne patients. Methods: 132 participants with mild moderate vulgaris participated this monocentric, prospective, double-blind study. Dermatologists grading and Standardized Skin Surface Biopsy were performed baseline after using only 7 d later. Results: There no significant difference between 2 times for each type acne, but number significantly decreased compared baseline....

Abstract Background The updated standard classification and pathophysiology of rosacea have provided clear meaningful evaluation parameters; however, differentiating from sensitive skin (SS) remained an obstacle for dermatologists around the world, especially in China. Herein, we aimed to find a better characteristic distinguish SS by using reflectance confocal microscopy (RCM). Method Forty patients 143 healthy subjects were recruited this study. Firstly, questionnaire lactic acid sting...

Background: Although Sensitive skin (SS) conditions are reported to be affected by climate changes, the correlations with meteorological parameters remain mostly unclear.Objective: To investigate changes of facial in different seasons Shanghai, including speed and severity influences imposed parameters.Methods: Totally eighty-one healthy female volunteers completed study both spring (May) summer (August). Evaluations included stimulating sensory test, clinical grading biophysical...

Abstract Skin ageing is a complex process. Both intrinsic and extrinsic factors have role in determining the speed, progression phenotypic outcomes of Typical clinical signs ageing, such as wrinkles, thinning sagging skin, are usually first noticed mid‐20s to early 30s. However, real‐world studies report that younger Asian women between ages 18 24 years perceiving emerging including dull uneven skin tone, dryness, transient lack firmness. These observations led hypothesis phase preageing may...

Background and Objective To compare changes in skin sensitivity before after treatment with a 1064‐nm Q‐switched Nd:YAG laser healthy individuals, to provide reference for clinicians use this reasonably. Study Design/Materials Methods Nineteen female volunteers underwent 10 random unilateral treatments. The transepidermal water loss rate (TEWL), glossiness, epidermal dermal thickness density, current perception threshold (CPT) value, facial blood perfusion were determined at different time...