A5101766652- Clinical practice guidelines implementation
- Bladder and Urothelial Cancer Treatments
- Wastewater Treatment and Nitrogen Removal
- Colorectal Cancer Screening and Detection
- Water Treatment and Disinfection
- Gut microbiota and health
- Coronary Interventions and Diagnostics
- Adipose Tissue and Metabolism
- Clostridium difficile and Clostridium perfringens research
- Urinary Bladder and Prostate Research
- Cardiac Imaging and Diagnostics
- Health Policy Implementation Science
- Advanced biosensing and bioanalysis techniques
- COVID-19 epidemiological studies
- Data-Driven Disease Surveillance
- Primary Care and Health Outcomes
- Skin Protection and Aging
- Genomics and Phylogenetic Studies
- Pancreatitis Pathology and Treatment
- Plant Molecular Biology Research
- Plant-Microbe Interactions and Immunity
- Advanced Nanomaterials in Catalysis
- Birth, Development, and Health
- Urinary Tract Infections Management
- Effects and risks of endocrine disrupting chemicals
Zhongnan Hospital of Wuhan University
2019-2025
Wuhan University
2019-2025
Imperial College London
2024-2025
Wenzhou Medical University
2025
Shenyang University of Technology
2022-2024
Wuxi Fourth People's Hospital
2024
Jiangnan University
2024
Jilin University
2024
Central South University
2021-2023
Yanbian University
2021-2023
BackgroundThe coronary sinus reducer (CSR) is proposed to reduce angina in patients with stable artery disease by improving myocardial perfusion. We aimed measure its efficacy, compared placebo, on ischaemia reduction and symptom improvement.MethodsORBITA-COSMIC was a double-blind, randomised, placebo-controlled trial conducted at six UK hospitals. Patients aged 18 years or older angina, disease, ischaemia, no further options for treatment were eligible. All completed quantitative...
Abstract Background The burden of common urologic diseases, including benign prostatic hyperplasia (BPH), urinary tract infections (UTI), urolithiasis, bladder cancer, kidney and prostate varies both geographically within specific regions. It is essential to conduct a comprehensive precise assessment the global diseases. Methods We obtained data on incidence, prevalence, mortality, disability-adjusted life-years (DALYs) for aforementioned diseases by age, sex, location, year from Global...
Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack comprehensive updated epidemiological data. This study aimed to investigate disease burden UTI, BPH 203 countries territories from 1990 2019.Data were extracted Global Burden Disease 2019, including incident cases, deaths, disability-adjusted life-years (DALYs) corresponding age-standardized rate (ASR) 2019....
Abstract SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported to promote tumor progression, however, the underlying mechanism remains unclear. Here we report that SLC12A5 functions as an oncogene progression and castration resistance of prostate cancer through N6-methyladenosine (m 6 A) reader YTHDC1 transcription factor HOXB13. We have shown level was increased in cancer, comparison its normal counterparts, further elevated castration-resistant (CRPC). The...
An exopolysaccharide, designated F1, was purified from the fermented milk by Lacticaseibacillus rhamnosus strain B6 (CGMCC No. 13310). with weight average molecular of 1.577 × 106 Da, is consisted rhamnose, glucose and galactose in a molar ratio 3.7:1.5: 1. The backbone included 1,3-linked Rha, 1,2,3-linked 1,2-linked Glc residues, branching point located at O2 position Rha residue, branch chain composed terminal linked residue pyruvate substituent. F1 could significantly stimulate...
Medical decision-making is a complex multi-stage process. Chinese cancer patients' preference for participation in stages, family involvement and influencing factors remain unclear. A total of 1,422 patients from four tertiary hospitals China were included the cross-sectional survey. Patient Expectation Participation Decision-making Scale was used to measure information, deliberation decisional control preferences. The patient-family Control Preferences expected actual levels involvement....
Nitrospira is a dominant nitrite-oxidizing bacterium in many artificial and natural environments. The discovery of complete ammonia oxidizers the genus prevents use previously identified primers targeting 16S rRNA gene or nitrite oxidoreductase ( nxr ) for differential determination strict bacteria (sNOB) among comammox this genus. We designed three novel primer sets that enabled quantification clades A B sNOB with high coverage, specificity, accuracy various With sets, were differentially...
The host genome may influence the composition of intestinal microbiota, and microbiota has a significant effect on muscle growth development. In this study, we found that deletion myostatin (MSTN) gene positively regulates expression tight junction-related genes TJP1 OCLN through myosin light-chain kinase/myosin light chain pathway. structure MSTN-/- pigs differed from wild-type, including by presence thicker muscularis longer plicae. Together, these changes affect microbiota. Mice...
The vital pathological processes in intimal hyperplasia include aberrant vascular smooth muscle cells (VSMCs) proliferation, migration, and phenotypic switching. Rosmarinic acid (RA) is a natural phenolic compound. Nevertheless, the underlying mechanism of RA neointimal still unclear. Our analysis illustrated that miR-25-3p mimics significantly enhanced PDGF-BB-mediated VSMCs switching while partially weakened effect miR-25-3p. Mechanistically, we found directly targets sirtuin (SIRT6)....
Developmental exposure to bisphenol A (BPA) has been linked impaired glucose homeostasis and pancreatic function in adulthood, which hypothesized result from the disruption of β-cell development at early life.
Ginsenoside Rg1 activates brown adipose tissue by modulating intestinal microbial and bile acid components to fight obesity in HFD-induced mice.
Abstract The prognosis of lung cancer is poor with few effective therapies. Targeting ferroptosis a new promising strategy for therapy. LINC00641 has been involved in several cancers, however, its specific roles treatment remain largely unknown. Here, we reported that was down-regulated tumor tissues and downregulation associated outcomes adenocarcinoma. localized primarily the nucleus modified by m 6 A. nuclear A reader YTHDC1 regulated expression affecting stability. We demonstrated...
P-nitrophenol (PNP) is a mono-nitrophenol compound that highly toxic and difficult to degrade, causing great harm the ecological environment human health. In this study, membrane aerated biofilm reactor (MABR) was used degrade high PNP concentration without external carbon sources. This experiment mainly presented process performance of MABR under high-load shock variations in community biodiversity compositions biofilm. The experimental results showed as influent gradually increased from...
Abstract Rapid alkalinization factors (RALFs) are cysteine-rich peptides that play important roles in a variety of biological processes, such as cell elongation and immune signaling. Recent studies Arabidopsis have shown RALFs regulate pollen tube growth via plasma membrane receptor-like kinases (RLKs). However, the downstream signal transduction mechanisms RLKs tubes unknown. Here, we identified PbrRALF2, pear (Pyrus bretschneideri) RALF peptide inhibits growth. We found PbrRALF2 interacts...
CPGs are not uniformly successful in improving care and several instances of implementation failure have been reported. Performing a comprehensive assessment the barriers enablers is key to developing an informed strategy. Our objective was investigate determinants guideline explore associations self-reported adherence guidelines with characteristics participants China.This cross-sectional survey, using multi-stage stratified typical sampling based on China's economic regional divisions (the...
Strain JR3T was isolated from Chinese pickled potherb mustard (Brassica juncea Coss.) purchased a local market in Shanghai, China. A polyphasic approach including 16S rRNA gene sequence analysis, average nucleotide identity (ANI) digital DNA-DNA hybridization (dDDH), determination of G+C content and various phenotypic analyses employed to characterize strain JR3T. The bacterium rod-shaped, Gram-stain-positive, terminal round endospore-forming catalase-positive. could grow at wide range...
As a member of Acinetobacter calcoaceticus-baumannii complex, pittii has been an emerging concern in nosocomial infection due to its increasing prevalence and multidrug resistance (MDR). However, population structure remains broadly unknown, hampering efficient tracing transmission evolution. In this study, we developed distributed core genome multilocus sequence typing (dcgMLST) for A. based on 750 genomes employed it map the genetic landscape evolution pittii. The results demonstrated that...