A5100710301- Protein Structure and Dynamics
- Noise Effects and Management
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Hearing Loss and Rehabilitation
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Hearing, Cochlea, Tinnitus, Genetics
- DNA and Nucleic Acid Chemistry
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Analytical Chemistry and Chromatography
- Occupational and environmental lung diseases
- Workplace Health and Well-being
- Sulfur Compounds in Biology
- Prostate Cancer Treatment and Research
- Medical Imaging and Pathology Studies
- Phonocardiography and Auscultation Techniques
- Nuclear Receptors and Signaling
- Musculoskeletal pain and rehabilitation
- Biochemical Analysis and Sensing Techniques
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Advanced oxidation water treatment
- Biomedical Text Mining and Ontologies
Huazhong University of Science and Technology
2019-2025
University of Chinese Academy of Sciences
2024-2025
Research Center for Eco-Environmental Sciences
2024-2025
Chinese Academy of Sciences
2024-2025
Sino-Danish Centre for Education and Research
2025
Tongji Hospital
2025
Ministry of Ecology and Environment
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Zhongshan Hospital
2024
Fudan University
2024
Abstract SLC12A5, a neuron-specific potassium-chloride co-transporter, has been reported to promote tumor progression, however, the underlying mechanism remains unclear. Here we report that SLC12A5 functions as an oncogene progression and castration resistance of prostate cancer through N6-methyladenosine (m 6 A) reader YTHDC1 transcription factor HOXB13. We have shown level was increased in cancer, comparison its normal counterparts, further elevated castration-resistant (CRPC). The...
Ferroptosis is a unique cell death mode that relies on iron and lipid peroxidation (LPO) extensively utilized to treat drug-resistant tumor. However, like the other antitumor model, requirement of oxygen limited its application in treating malignant tumors anaerobic environments, just as photodynamic therapy, very promising anticancer therapy. Here, we show an iridium(III) complex (Ir-dF), which was often used proton-coupled electron transport (PCET) process, can induce efficient upon photo...
Abstract Background Cyclin‐dependent kinase 12 (CDK12)‐deficient prostate cancer defines a subtype of castration‐resistant (CRPC) with poor prognosis. Current therapy, including PARP inhibitors, shows minimal treatment efficacy for this CRPC, and the underlying mechanism remains elusive. Methods Based on bioinformatics analysis, we evaluated relationship between CDK12 deficiency patient's prognosis resistance. Furthermore, used CRISPR‐Cas9 technology mass spectrometry‐based metabolomic...
It is well known that hydroxyl radical (·OH) can be largely produced either through the classic iron-mediated inorganic-Fenton system or our recently discovered haloquinones/H2O2 organic-Fenton-like system, but rarely via thiol compounds. Here, unexpectedly, we found ·OH unequivocally generated by incubation of H2O2 and mercaptotriazole (MTZ), a typical heterocyclic which has been used as an environmentally friendly corrosion inhibitor for mild steel. By complementary applications HPLC-MS...
Abstract Objective This study aimed to assess the association of shift work with blood glucose and mediating role oxidative stress. Methods Fasting plasma (FPG) urinary concentrations stress biomarkers (8‐hydroxy‐2'‐deoxyguanosine [8‐OHdG], 4‐hydroxy‐2‐nonenal‐mercapturic acid, 8‐iso‐prostaglandin F 2α [8‐isoPGF ]) were measured among 831 participants. Results Positive dose‐response relationships duration, FPG ( p trend < 0.001), abnormal regulation (AGR; = 0.035) found. Compared...
In this paper, we calculate the absolute binding free energy of an insulin dimer by steered MD method. The result −8.97 kcal mol<sup>−1</sup>is close to experimental value −7.2 mol<sup>−1</sup>. We also analyze residue–residue interactions.
Constructing a free energy landscape for large molecule is difficult. One has to use either high temperature or strong driving force enhance the sampling on barriers. In this work, we propose mixed method that combines these two kinds of acceleration strategies into one simulation. First, it applies an adaptive biasing potential some replicas molecule. These are particularly accelerated in collective variable space. Second, places unbiased and exchangeable at various levels. generate data...
Purpose: Enhanced external counterpulsation (EECP) is popular in China for the treatment of coronary heart diseases, but it may be an effective other populations. This study aimed to explore effect EECP on exercise endurance healthy people and chronic obstructive pulmonary disease (COPD) patients provide intervention measures improve their physical condition. Patients methods: were enrolled this pilot randomized controlled trial at Jiangbin Hospital, China, between March 1st May 30th, 2018....
Reliable conformational sampling and trajectory analysis are always important to the study of folding or binding mechanisms biomolecules. Generally, one has prepare many complicated parameters follow a lot steps obtain final data. The whole process is too new users. In this article, we provide convenient user‐friendly tool that compatible AMBER, called fast (FSATOOL). FSATOOL some useful features. First most important, work extremely simplified into two steps, procedure other procedure....
Neratinib, an oral irreversible pan-HER tyrosine kinase inhibitor, was approved in 2020 China based on the ExteNET trial, which is no longer reflective of current treatment landscape HER2+ early breast cancer (EBC) China, with increasing clinical uses neoadjuvant and recently adjuvant anti-HER2 therapies including pertuzumab trastuzumab emtansine. Thus, there a need to understand real-world extended neratinib use China. This multi-center, prospective, non-interventional study planning enroll...
Abstract Apelin is an endogenous active peptide, playing a crucial role in regulating cardiovascular homeostasis. This study aimed to investigate the interaction between apelin and endoplasmic reticulum stress (ERS). Tunicamycin (Tm) dithiothreitol (DTT) were used induce ERS ex vivo cultured myocardium of rats. Myocardial injury was determined by activities lactate dehydrogenase creatine kinase-MB culture medium. The protein levels ERS-associated molecule, apelin, its receptor angiotensin...