A5084986757- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Plant-derived Lignans Synthesis and Bioactivity
- Biological and pharmacological studies of plants
- Bioactive natural compounds
- Bioactive Natural Diterpenoids Research
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical synthesis and alkaloids
- Botanical Research and Chemistry
- Phytochemical Studies and Bioactivities
- Cholinesterase and Neurodegenerative Diseases
- Plant Toxicity and Pharmacological Properties
- Plant biochemistry and biosynthesis
- Alkaloids: synthesis and pharmacology
- Plant and animal studies
- Ginseng Biological Effects and Applications
- biodegradable polymer synthesis and properties
- Phytochemical compounds biological activities
- Genomics, phytochemicals, and oxidative stress
- Fungal Plant Pathogen Control
- Polymer composites and self-healing
- Bioactive Compounds and Antitumor Agents
- Electrospun Nanofibers in Biomedical Applications
- Phytochemicals and Antioxidant Activities
Westlake University
2025
Sichuan University
2024-2025
Jiangnan University
2025
Yunnan Normal University
2015-2024
Sun Yat-sen University
2024
Xinjiang Academy of Agricultural Sciences
2017
Institute of Quality Standards and Testing Technology for Agro Products
2017
Kunming Institute of Botany
2013-2015
Chinese Academy of Sciences
2013
University of Chinese Academy of Sciences
2013
From the whole plant of Dendrobium devonianum, a new flavonol glycoside, 5-hydroxy-3-methoxy-flavone-7-O-[β-d-apiosyl-(1 → 6)]-β-d-glucoside, as well 13 known compounds, was isolated. Their structures were identified based on extensive spectroscopic studies including HR-EI-MS, 1H, 13C NMR, DEPT, H–H COSY, HSQC, HMBC and NOESY spectra. The compound gigantol evaluated for their α-glucosidase inhibitory activity, both displayed more potent activity than acarbose, one most inhibitor drugs, with...
Poly(butylene adipate-co-terephthalate) (PBAT) is a thermoplastic biodegradable polyester with broad market prospects due to its desirable toughness, ductility, and water resistance. However, compared traditional plastics, insufficient mechanical strength limited scope of applications. Herein, inspired by the reinforcement concept polyurethane leveraging rich presence aromatic rings in PBAT molecular chain, we incorporated cation–π hydrogen-bonding interactions into chains enhance...
Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures 1 including their absolute configurations, determined by spectroscopic methods, single-crystal X-ray diffraction analysis, chemical methods. Compound showed weak cytotoxicity moderate immunosuppressive activity.
The longstanding challenge of limited exploration in protein receptor conformational space continues to constrain the precision molecular docking. Ensemble docking, which employs methods such as dynamics simulations generate multiple conformations for has improved accuracy but remains by incomplete sampling and an inability fully account ligand-induced fit. To address these limitations, we introduce concept individual a novel approach that involves docking against generated individually each...
A new diarylpropanoid, horsfiequinone (<b>1</b>), and five dimeric diarylpropanoids with 1,4-<i>p</i>-benzoquinone residue, horsfiequinones B–F (<b>2</b>–<b>6</b>), along a known compound, combrequinone B (<b>7</b>), were isolated from <i>Horsfieldia tetratepala</i>. Their structures elucidated by means of spectroscopic analysis. Horsfiequinones as enantiomer mixtures unequal proportions, verified analysis on chiral OD-H HPLC column. Cytotoxicity evaluation against human tumor lines showed...
Two new isopentenyl bibenzyls, denchrysotonols A and B (1-2), along with 26 known phenolic compounds, were isolated from the stems of cultivated Dendrobium chrysotoxum Lindl. Their chemical structures clearly elucidated by extensive spectroscopic analysis. Biological evaluation compounds revealed that phenanthrenes (14, 16-17, 20, 22) fluorenone 25 exhibited anti-inflammatory activities which inhibited nitric oxide (NO) production in LPS-activated RAW264.7 macrophages IC50 values ranging 9.4...
Two new bibenzyl-phenylpropane hybrids, dendrophenols A and B (1 2), along with nine known bibenzyls, were isolated from the aerial part of Dendrobium devonianum Paxt. Their structures determined by extensive spectroscopic methods methylation. Bioassays revealed that compounds 1-9 specifically immunosuppressive to T lymphocytes IC50 values ranging 0.41 9.4 μM, which 1 (IC50 =1.62 μM) 2 =0.41 promising agents for selectivity indices 19.9 79.5, respectively.
AbstractA new isoflavanone, 2,2′-epoxy-4′-methoxy-3,7-dihydroxyisoflavanone (1), and a natural coumaranone, 2-hyroxy-2-(4′-methoxybenzyl)-6-methoxy-3-coumaranone (2), along with 26 known compounds, were first isolated from the trunk of Horsfieldia pandurifolia. Their structures elucidated by means spectroscopic analysis. Compound 1 was assessed for its cytotoxicity against five human tumour lines (HL-60, SMMC-7721, A-549, MCF-7 SW-480), result showed that it has no activity.Keywords:...
Abstract Fifteen bibenyls and four fluorenones, including five new bibenzyl–phenylpropane hybrids, were isolated from the aerial part of Dendrobium nobile Lindl. Their structures determined by spectroscopic methods. Bioassay on LPS–induced proliferations mouse splenic B lymphocytes, Con A‐induced T lymphocytes showed that compounds 1 , 2 14 excellent immunosuppressive activities with IC 50 values 1.23, 1.01, 3.87 μ M, respectively, while 3 – 4 7 10 13 15 exhibited moderate ranging 6.89 to 14.2 M.
Five compounds, including a new dimeric diarylpropane, were isolated from the petroleum ether extract of twigs and leaves Horsfieldia tetratepala. The structures these compounds elucidated by spectroscopic analysis. Moreover, antiproliferative activities tested on cancer cell lines, but none is active.
From the extracts of Dimocarpus longan Lour leaves, 2 unusual flavonol glycosides, quercetin 3-O-(3″-O-2‴-methyl-2‴-hydroxylethyl)-β-d-xyloside (1) and 3-O-(3″-O-2‴-methyl-2‴-hydroxylethyl)-α-l-rhamnopyranoside (2), as well 10 known compounds including afzelin (3) kaempferol-3-O-α-l-rhamnopyranoside (4), flavans, ( − )-epicatechin (5) proanthocyanidin A-2 (6), 3 triterpenoids, friedelin (7), epifriedelanol (8) β-amyrin (9), a peptide, N-benzoylphenylalanyl-N-benzoylphenylalaninate (10),...
A new (propylphenyl)bibenzyl, bambusifolol (1), along with six known compounds, batatasin III (2), tristin (3), 3-hydroxy-5-methoxy bibenzyl (4), gigantol (5), 3′,5-dimethoxy-9,9′-diacetyl-4,7′-epoxy-3,8′-bilign-7-ene-4′-methol (6) and balanophonin (7) were isolated from the whole plants of Eria bambusifolia. Their structures elucidated by means extensive spectroscopic analysis. 3–7 genus for first time 2 obtained originally E. All compounds evaluated their cytotoxicity against human tumour...
Horisfieldones A (1) and B (2), two dimeric diarylpropanes featuring an unprecedentedly aromatic ring-contracted framework, were isolated from Horsfieldia kingii. Their structures absolute configurations determined by the inspection of extensive spectroscopic data electronic circular dichroism calculations. Molecular modeling analysis, in vitro enzyme-based bioassays, structure–activity relationship analysis these isolates revealed that (+)-1 (IC50 = 35.1 ± 3.9 μM, SI > 11.4) could present a...
Two new flavans, (2R, 4R)-4'-hydroxy-3',5'-methyl-6,7-methylenedioxy-4-O-2'-cycloflavan (1), and 4R)-4'-hydroxy-3'-methyl-6,7-methylenedioxy-4-O-2'-cycloflavan (2), along with six known compounds were isolated from the trunk leaves of Horsfieldia glabra. Their structures elucidated by means extensive spectroscopic analysis. Compounds 1 2, together 4-7 assessed for their cytotoxicity against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7 SW-480), result showed that they had no activity.