A5100414326- Sulfur Compounds in Biology
- Traditional and Medicinal Uses of Annonaceae
- Molecular Sensors and Ion Detection
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Eicosanoids and Hypertension Pharmacology
- Obstructive Sleep Apnea Research
- Hydrogen's biological and therapeutic effects
- Inflammatory mediators and NSAID effects
- Pancreatitis Pathology and Treatment
- Nanoplatforms for cancer theranostics
- Phagocytosis and Immune Regulation
- Air Quality and Health Impacts
- Medicinal Plants and Bioactive Compounds
- Folate and B Vitamins Research
- Pancreatic and Hepatic Oncology Research
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical and Molecular Research
- Advanced Nanomaterials in Catalysis
- Microscopic Colitis
- Cancer, Hypoxia, and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Asymmetric Hydrogenation and Catalysis
- Gut microbiota and health
Guilin Medical University
2019-2024
University of South China
2023
Shanxi University
2023
Central South University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Ningbo University
2020
Wuhan University
2019
Renmin Hospital of Wuhan University
2019
Peking University
2018
State Key Laboratory for Structural Chemistry of Unstable and Stable Species
2018
Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine biosynthesis. Paradoxically, PHGDH and synthesis are required presence of abundant environmental even when uptake exceeds requirements for nucleotide synthesis. Here, we establish a mechanism how maintains metabolism. We show that inhibition induces alterations metabolism independent utilization. These changes not attributable to defects serine-derived redox maintenance, another key aspect metabolism, but...
Acute pancreatitis (AP) is a clinically frequent acute abdominal condition, which refers to an inflammatory response syndrome of edema, bleeding, and even necrosis caused by abnormal activation the pancreas's own digestive enzymes. Intestinal damage can occur early in course AP manifested impaired intestinal mucosal barrier function, reactions mucosa, among other factors. It cause translocation bacteria endotoxins, further aggravating condition AP. Therefore, actively protecting barrier,...
A new diarylpropanoid, horsfiequinone (<b>1</b>), and five dimeric diarylpropanoids with 1,4-<i>p</i>-benzoquinone residue, horsfiequinones B–F (<b>2</b>–<b>6</b>), along a known compound, combrequinone B (<b>7</b>), were isolated from <i>Horsfieldia tetratepala</i>. Their structures elucidated by means of spectroscopic analysis. Horsfiequinones as enantiomer mixtures unequal proportions, verified analysis on chiral OD-H HPLC column. Cytotoxicity evaluation against human tumor lines showed...
Metastasis and invasion are the main causes of mortality in gastric cancer. To improve treatment cancer, development effective innovative antitumor agents toward proliferation is needed. Alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, showed antiproliferative cytotoxic effects on several cancers. So it feasible to explore whether ALA can be used inhibit human The expression MUC4 cancer tissues was assayed by immunohistochemistry. Then, we performed vitro cell analysis...
The present study explored the protective effect of exogenous hydrogen sulfide (H<sub>2</sub>S) on lipopolysaccharide (LPS)‑induced acute kidney injury (AKI) and underlying mechanisms. To establish an AKI mouse model, LPS (10 mg/kg) was intraperitoneally injected into mice pretreated with 0.8 mg/kg sodium hydrosulfide hydrate (NaHS), H<sub>2</sub>S donor. survival rate degree were examined. construct a cell damage HK‑2 cells different concentrations (0.1, 0.3 0.5 mM) NaHS, then stimulated (1...
Five compounds, including a new dimeric diarylpropane, were isolated from the petroleum ether extract of twigs and leaves Horsfieldia tetratepala. The structures these compounds elucidated by spectroscopic analysis. Moreover, antiproliferative activities tested on cancer cell lines, but none is active.
Three new fluorescent probes for sensitive, selective and rapid detection of SO<sub>2</sub> derivatives visual gas.
Hydrogen sulfide (H2S) has been reported to participate in intestinal mucosal defense and repair. However, the precise regulatory mechanisms of H2S ulcerative colitis (UC) remain unclear. We explored effects sodium hydrosulfide (NaHS), a donor H2S, dextran sulfate (DSS)-induced rats. The pathologic features were determined by analyzing hematoxylin eosin-stained samples. Interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) levels using ELISA. presence...
Background Arachidonic acid (AA) metabolic network is activated in the most inflammatory related diseases, and small‐molecular drugs targeting AA are increasingly available. However, side effects of above mentioned have always been biggest obstacle. (+)‐2‐(1‐hydroxyl‐4‐oxocyclohexyl) ethyl caffeate (HOEC), a natural product acted as an inhibitor 5‐lipoxygenase (5‐LOX) 15‐LOX vitro , exhibited weaker therapeutic effect high dose than that low to collagen induced arthritis (CIA) rats. In this...
Background. Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that commonly affects the health many individuals. Esculentoside A (EsA), saponin extracted from roots Phytolacca esculenta, has antioxidative and anti-inflammatory effects against various diseases. Nonetheless, its role in UC undetermined. Hence, this study, we examined therapeutic EsA UC. Methods. Primary intestinal neuronal cells (in vitro) were treated with lipopolysaccharide (LPS) to induce injury. An vivo...
Abstract We conjugated aldehyde‐BODIPY with the water‐soluble iodopropionic‐acid‐hemicyanine to develop a new dual‐color fluorescence probe (BHC) for selective and sensitive monitoring of endogenous SO 2 first time. Through excellent water solubility unique nucleophilic addition reaction, BHC has higher selectivity colorimetric than other related substances. The resulting red emission, can be converted green emission after reacting . Then was further applied image intracellular generated 3...
Hydrogen sulfide (H2S) is a newly recognized endogenously generated gasotransmitter. Endogenous H2S has been shown to be related several gastrointestinal diseases, including irritable bowel syndrome, Crohn's disease, and ulcerative colitis. We explored the functional role of in colitis investigated underlying mechanism.Rats were randomly divided into control, model, sodium hydrosulfide (NaHS) groups. Rat was evaluated using disease activity index hematoxylin eosin (HE) staining. The...