A5100714196- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Analytical chemistry methods development
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Natural product bioactivities and synthesis
- Advanced biosensing and bioanalysis techniques
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Alzheimer's disease research and treatments
- Genetics and Neurodevelopmental Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mass Spectrometry Techniques and Applications
- Plant Toxicity and Pharmacological Properties
- Innovative Microfluidic and Catalytic Techniques Innovation
- Remote Sensing and Land Use
- RNA modifications and cancer
- Circular RNAs in diseases
- Virus-based gene therapy research
- Systemic Sclerosis and Related Diseases
Harbin Medical University
2010-2025
Huazhong University of Science and Technology
2017-2025
Central Hospital of Wuhan
2017-2025
Tianjin University of Science and Technology
2022-2025
Third Affiliated Hospital of Harbin Medical University
2013-2024
Zhuzhou Central Hospital
2023-2024
Central South University
2015-2024
Dalian Medical University
2018-2023
First Affiliated Hospital of Dalian Medical University
2018-2023
Peking Union Medical College Hospital
2023
Epithelial to mesenchymal transition (EMT) can contribute gastric cancer (GC) progression and recurrence following therapy. Tumor-associated neutrophils (TANs) are associated with poor outcomes in a variety of cancers. However, it is not clear whether TANs interact the EMT process during GC development. Immunohistochemistry was performed examine distribution levels CD66 + samples from 327 patients GC. CD66b were isolated either directly cell suspensions or conditioned healthy donor...
Abstract Background Esophagogastroduodenoscopy (EGD) is a prerequisite for detecting upper gastrointestinal lesions especially early gastric cancer (EGC). An artificial intelligence system has been shown to monitor blind spots during EGD. In this study, we updated the (ENDOANGEL), verified its effectiveness in improving endoscopy quality, and pretested performance EGC multicenter randomized controlled trial. Methods ENDOANGEL was developed using deep convolutional neural networks...
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer's disease (AD), implicating key roles chromosome 21-encoded genes in pathogenesis AD. We previously identified a role deubiquitinase USP25, encoded on regulating microglial homeostasis AD brain; however, whether USP25 affects amyloid pathology remains unknown. Here, by crossing 5×FAD and Dp16 DS mice, we observed that 21 exacerbated brain. Moreover, bacterial artificial (BAC) transgene-mediated...
Platelet and blood coagulation abnormalities frequently occur in cancer patients. Fibrinogen is an important hemostatic factor that regulates the pathway. Hyperfibrinogenemia increasing recognized as risk influencing development outcome. However, few reports have investigated prognostic potential of fibrinogen for predicting survival gastric (GC) The primary aim this study was to evaluate usefulness preoperative serum a biomarker predicating tumor progression patients with GC. This...
The dismal prognosis of gastric cancer patients is a global problem. We aim to evaluate the clinicopathologic features and prognostic factors proximal distal cancer.Gastric cases diagnosed treated at same surgical unit between 2007 2010 were reviewed. Follow-up data from all collected for least 5 years until 2015. A total 964 studied (distal [DG], n=777 [PG], n=187).DG had relatively higher percentage females, more thorough therapy (R0 [D0/D1/D2]), fewer combined organ resections, younger...
An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed RNA LINC00461 is highly expressed glioma tissues compared to non-neoplastic brain tissues. The knockdown suppressed cyclinD1/A/E expression which led G0/G1 cell cycle arrest and inhibited proliferation cells. suppression also migration invasion. function cells partially mediated by MAPK/ERK PI3K/AKT signaling pathways as down-regulation ERK1/2 AKT activities....
Interstitial lung disease (ILD) is a common extra-articular manifestation of rheumatoid arthritis (RA) and associated with high mortality, especially in progressive ILD. We aimed to identify predictors progression the early stages ILD large sample patients RA.The medical records 201 RA-ILD were retrospectively analyzed. According changes their pulmonary function tests, divided into stable groups. Data collected on clinical characteristics, laboratory findings, chest high-resolution computed...
Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder. Although these findings link USP6 to higher brain function, potential roles for cognition have not been investigated. Here, we report that highly expressed induced human neurons neuron-specific expression of enhances learning memory transgenic mouse model. Similarly, regulates N-methyl-D-aspartate-type glutamate receptor (NMDAR)-dependent...
<title>Abstract</title> Background: Although ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 1(ASAP1) is involved in the development of various malignancies, its clinical significance mechanism gastric cancer (GC) remains unclear.Methods: The effects ASAP1 on tumor progression, angiogenesis, epithelial-mesenchymal transition were evaluated vitro. growth angiogenesis also explored vivo. Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases used to gather expression...
To evaluate the prognostic value of monocyte to lymphocyte ratio (MLR) and folate receptor-positive circulating tumor cells (FR+CTCs) in patients with colorectal cancer (CRC) develop predictive model for post-treatment survival using machine learning (ML) algorithms. We retrospectively analyzed 67 CRC treated radical surgery or chemoradiotherapy at The Central Hospital Wuhan from January 2020 December 2022. MLR, neutrophil (NLR), platelet (PLR) FR+CTCs were categorized into high low groups...