Tie Li

ORCID: 0000-0001-9907-0188
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Research Areas
  • Nanowire Synthesis and Applications
  • Gas Sensing Nanomaterials and Sensors
  • Analytical Chemistry and Sensors
  • Graphene research and applications
  • Advanced biosensing and bioanalysis techniques
  • Mechanical and Optical Resonators
  • Advancements in Semiconductor Devices and Circuit Design
  • Advanced MEMS and NEMS Technologies
  • Force Microscopy Techniques and Applications
  • Advanced Chemical Sensor Technologies
  • Carbon Nanotubes in Composites
  • Semiconductor materials and devices
  • Photonic and Optical Devices
  • Transition Metal Oxide Nanomaterials
  • Magnetic properties of thin films
  • Advanced Thermoelectric Materials and Devices
  • Magnetic Properties and Applications
  • Thermal properties of materials
  • Advanced Sensor and Energy Harvesting Materials
  • Biosensors and Analytical Detection
  • Nanopore and Nanochannel Transport Studies
  • Advanced Fiber Optic Sensors
  • Thermal Radiation and Cooling Technologies
  • Metallic Glasses and Amorphous Alloys
  • Advancements in Battery Materials

Shanghai Institute of Microsystem and Information Technology
2016-2025

State Key Laboratory of Transducer Technology
2010-2025

Chinese Academy of Sciences
2014-2024

North China Electric Power University
2023-2024

University of California, Los Angeles
2016-2024

Guizhou Electromechanical Research and Design Institute
2012-2024

Jilin University
2024

First Hospital of Jilin University
2024

Shenzhen Metro (China)
2024

Institute of Electrical and Electronics Engineers
2023

We herein report the design of a novel semiconducting silicon nanowire field-effect transistor (SiNW-FET) biosensor array for ultrasensitive label-free and real-time detection nucleic acids. Highly responsive SiNWs with narrow sizes high surface-to-volume-ratios were "top-down" fabricated complementary metal oxide semiconductor compatible anisotropic self-stop etching technique. When covalently modified DNA probes, nanosensor showed highly sensitive concentration-dependent conductance change...

10.1021/nl202303y article EN Nano Letters 2011-08-17

Silicon nanowire (SiNW) field effect transistors (FETs) have emerged as powerful sensors for ultrasensitive, direct electrical readout, and label-free biological/chemical detection. The sensing mechanism of SiNW-FET can be understood in terms the change charge density at SiNW surface after hybridization. So far, there been limited systematic studies on fundamental factors related to device sensitivity further make clear overall sensitivity. Here, we present an analytical result our triangle...

10.1021/nl302476h article EN Nano Letters 2012-09-17

The chemiresistive thin film gas sensors with fast response, high sensitivity, low power consumption and mass-produced potency, have been expected for practical application. It requires both sensitive materials, especially exquisite nanomaterials efficient substrate chip heating electrical addressing. However, it is challenging to achieve repeatable microstructures across the films of chip. Here we presented a new sensor structure via fusion metal-oxide nanoporous micro-electro-mechanical...

10.1038/srep01669 article EN cc-by-nc-nd Scientific Reports 2013-04-17

Abstract For point-of-care (POC) applications, robust, ultrasensitive, small, rapid, low-power and low-cost sensors are highly desirable. Here, we present a novel biosensor based on complementary metal oxide semiconductor (CMOS)-compatible silicon nanowire tunneling field-effect transistor (SiNW-TFET). They were fabricated “top-down” with anisotropic self-stop etching technique. Notably, the SiNW-TFET device provided strong anti-interference capacity by applying inherent ambipolarity via...

10.1038/srep22554 article EN cc-by Scientific Reports 2016-03-02

MicroRNAs (miRNAs) have been regarded as promising biomarkers for the diagnosis and prognosis of early‐stage cancer their expression levels are associated with different types human cancers. However, it is a challenge to produce low‐cost miRNA sensors, well retain high sensitivity, both which essential factors that must be considered in fabricating nanoscale biosensors future biomedical applications. To address such challenges, we develop complementary metal oxide semiconductor...

10.1002/smll.201302990 article EN Small 2014-02-27

We employed RbI additive, constructed heterojunction, and used TOPO post-treatment for suppressing non-radiative recombination of MA-free WBG perovskite. The device showed a record PCE 23.35%, high V OC 1.3 the impressive stability.

10.1039/d4ee00666f article EN Energy & Environmental Science 2024-01-01

The mechanical properties of black phosphorus (BP) nanosheets suspended over circular holes were measured by an atomic force microscope nanoindentation method. continuum mechanic model was introduced to calculate the elastic modulus and pretension BP with thicknesses ranging from 14.3 34 nm. Elastic declines thickness, maximum value is 276 ± 32.4 GPa. Besides, effective strain ranges 8 17% a breaking strength 25 Our results show that serve as promising candidate for flexible electronic applications.

10.1063/1.4939233 article EN Applied Physics Letters 2016-01-04

Herein, we describe a novel approach for rapid, label-free and specific DNA detection by applying rolling circle amplification (RCA) based on silicon nanowire field-effect transistor (SiNW-FET) the first time. Highly responsive SiNWs were fabricated with complementary metal oxide semiconductor (CMOS) compatible anisotropic self-stop etching technique which eliminated need hybrid method. The probe was immobilized surface of SiNW, followed sandwich hybridization perfectly matched target RCA...

10.1021/nl401628y article EN Nano Letters 2013-08-12

Promoter mutation in the human telomerase reverse transcriptase gene (hTERT) occurs ~75% of primary glioblastoma (GBM). Although appears to upregulate expression and contributes maintenance telomere length, its clinical significance remains unclear.We performed hTERT promoter genotyping on 303 isocitrate dehydrogenase 1 wild-type GBM tumors treated with standard chemoradiotherapy. We also stratified 190 patients from database The Cancer Genome Atlas (TCGA) by expression. analyzed overall...

10.1093/neuonc/now189 article EN Neuro-Oncology 2016-08-29

A direct, rapid, highly sensitive and specific biosensor for detection of cancer biomarkers is desirable in early diagnosis prognosis cancer. However, the existing methods detecting suffer from poor sensitivity as well requirement enzymatic labeling or nanoparticle conjugations. Here, we proposed a two-channel PDMS microfluidic integrated CMOS-compatible silicon nanowire (SiNW) field-effect transistor arrays with potentially single use label-free ultrasensitive electrical biomarkers. The...

10.1021/acs.analchem.5b01729 article EN Analytical Chemistry 2015-10-16

Abstract Nano-structured gas sensing materials, in particular nanoparticles, nanotubes and nanowires, enable high sensitivity at a ppb level for sensors. For practical applications, it is highly desirable to be able manufacture such sensors batch low cost. We present here strategy of in-situ wafer-level fabrication the high-performance micro/nano chips by naturally integrating microhotplatform (MHP) with nanopore array (NPA). By introducing colloidal crystal template, ordered homogenous SnO...

10.1038/srep10507 article EN cc-by Scientific Reports 2015-05-22

Noble metals supported on metal oxides are promising materials for widely applying gas sensors because of their enviable physical and chemical properties in enhancing the sensitivity selectivity. Herein, pristine ZFO yolk-shell spheres composed ultrathin nanosheets ultrasmall nanoparticles decorated with nanosized Au particles a diameter 1-2 nm fabricated using method solution-phase deposition-precipitation. As result, Au@ZFO sphere based sensor exhibits significantly sensing performances...

10.1021/acsami.0c00525 article EN ACS Applied Materials & Interfaces 2020-03-17

Tuberculosis (TB) mostly spreads from person to through Mycobacterium tuberculosis (MTB). However, the majority of conventional detection methods for MTB cannot satisfy requirements actual TB detection. As one most promising powerful platforms, a silicon nanowire field-effect transistor (SiNW-FET) biosensor shows good prospect in In this study, an enhanced SiNW-FET was developed rapid and sensitive MTB. The surface functional parameters were explored optimized. has sensitivity with limit...

10.1021/acssensors.1c01227 article EN ACS Sensors 2021-09-02

This research investigated the long-term performance of zero-valent iron aggregates for reductive dechlorination trichloroethylene (TCE) and perchloroethylene (PCE). The effects elapsed time, mass transfer limitations, influent halocarbon concentration on rates were using groundwater obtained from a field site contaminated with chlorinated organic compounds. Over first 300 days operation, reaction TCE PCE gradually increased due to increasing porosity aggregates. Although there was microbial...

10.1021/es991135b article EN Environmental Science & Technology 2000-05-05

Ultrasensitive and complementary electrical detection of prostate cancer biomarkers with n- p-type silicon nanowire sensor arrays.

10.1039/c4nr03210a article EN Nanoscale 2014-01-01
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