A5023235352- Pulmonary Hypertension Research and Treatments
- CRISPR and Genetic Engineering
- Zebrafish Biomedical Research Applications
- RNA Research and Splicing
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Polysaccharides and Plant Cell Walls
- Advanced biosensing and bioanalysis techniques
- Polysaccharides Composition and Applications
- Enzyme Production and Characterization
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Advancements in Solid Oxide Fuel Cells
- Cardiovascular Function and Risk Factors
- Bacterial biofilms and quorum sensing
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Renal and related cancers
- Memory and Neural Mechanisms
- Salmonella and Campylobacter epidemiology
- Endoplasmic Reticulum Stress and Disease
- Probiotics and Fermented Foods
- Nuclear Receptors and Signaling
- Nuclear Structure and Function
University of Macau
2022-2025
Renji Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Xinjiang University
2025
China Tobacco
2025
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sun Yat-sen University
2023-2024
Capital Medical University
2024
South China University of Technology
2024
Guangxi Medical University
2024
This protocol describes regular care and maintenance of a zebrafish laboratory. Zebrafish are now gaining popularity in genetics, pharmacological behavioural research. As vertebrate, share considerable genetic sequence similarity with humans being used as an animal model for various human disease conditions. The advantages comparison to other common vertebrate models include high fecundity, low cost, transparent embryos, rapid development. Due the spur interest research, need establish...
There is growing interest in using zebrafish (Danio rerio) as a model of neurodegenerative disorders such Alzheimer's disease. A tauopathies has recently been developed and characterized terms presence the pathological
The article is devoted to the existence and Hyers-Ulam stability of almost periodic solution fractional differential equation with impulse Brownian motion under nonlocal condition. investigation mainly based on semigroups operators method Mönch fixed points method, as well basic theory stability.
Developing efficient strategies for sensitive detection of microRNAs, the noncoding bioactive molecules and well-established biomarkers, has aroused great interests due to its potential values in genetic pathological analyses. Herein, a highly selective disposable paper-based photoelectrochemical (PEC) sensor was rationally designed sensing microRNA based on simple self-assembly target-triggerable DNA motor nanozyme-catalyzed multistage biocatalytic precipitation reaction. Specifically,...
Abstract Background Endoplasmic reticulum (ER) stress has been found to foster the escape of cancer cells from immune surveillance and upregulate PD-L1 expression. However, underlying mechanisms are unknown. Methods While analyzing protein levels using immunofluorescence Western blotting, RNA were measured qRT-PCR. Ten injection exosomes into six-week-old nude mice was made through tail vein once every other day in total. Results The expression certain ER markers such as PERK (PKR-like...
Accurate diagnosis and therapy are challenging because most diseases lack a single biomarker that distinguishes them from other disorders. A solution would enhance targeting accuracy by using AND-gated combinations of two disease-associated stimuli. Here, we report novel "AND" molecular logic gate, enabling double-controlled release intact functional molecules. Benefiting significant difference in intramolecular cyclization rate, cargo occurs notably faster with the presence both According...
Tumour-associated macrophages (TAMs) are thought to contribute oral squamous cell carcinoma (OSCC) initiation and progression. However, the underlying mechanism through which TAMs foster OSCC progression is still unclear. This study intended determine whether there exclusively exosomal miRNAs-derived that functionally necessary for The phenotype of TAM recruitment in tissue samples was assessed, subsequently identifying influence M2 exosomes derived from on proliferation tumorigenesis vitro...
Abstract Embryo loss and pregnancy disorders are prevalent worldwide, with both conditions critically associated dysfunctioning gastrulation processes. Gastrulation post-gastrulation organogenesis crucial stages of embryonic development that establish the blueprint for body part formation. These processes involve sequential generation three germ layer cells primordial cells, as well assembly precursor tissues parts. However, due to ethical limitations studying human embryogenesis, a more...
Introduction: Acute myocardial infarction (AMI) is characterized by the loss of cardiomyocytes, which impairs cardiac function and eventually leads to heart failure. The induction cardiomyocyte cell cycle activity provides a new treatment strategy for repair damage. Our previous study demonstrated that morroniside exerts cardioprotective effects. This investigated effects underlying mechanisms action on following AMI. Methods: Neonatal rat cardiomyocytes (NRCMs) were isolated exposed...
Microtubule-associated protein tau (MAPT) is the major component of neurofibrillary tangles found in brains those suffering from Alzheimer's disease. Various forms lesions are other neurodegenerative diseases (tauopathies).
More and more people are aware of the importance intestinal flora to human health, interested in regulation its interaction with host. The survival status probiotics gastrointestinal environment microbial interactions between lactic acid bacteria have also received considerable attention. In this study, tolerance, adhesion ability, biofilm formation Lactobacillus strain coculture system were explored through real-time fluorescence-based quantitative PCR, UPLC-MS/MS metabolic profiling...
In migratory fibroblasts, the front-rear polarity required for cell migration is defined by an anterior centrosome relative to nucleus. To achieve this polarity, actin cables drive nucleus backward coupling nuclear membrane proteins nesprin-2G and SUN2. Aging disrupts increasing protein levels of SUN1, a SUN2 homolog. Here, we investigated molecular mechanisms behind disruption found that dominant negative effect SUN1 progerin, aging-related lamin A variant, direct SUN1-lamin interaction....
<title>Abstract</title> Spatial autocorrelation is an important epidemiological feature of hand, foot, and mouth disease (HFMD). However, few studies have included this in the regression relationship between HFMD incidence driving factors to explore its impact on incidence. In paper, we propose a mixed geographically temporally weighted autoregressive (MGTWAR) model spatial meteorological among children Inner Mongolia, China, 2016. The bootstrap test method was introduced identify that...
This protocol describes regular care and maintenance of a zebrafish laboratory. Zebrafish are now gaining popularity in genetics, pharmacological behavioural research. As vertebrate, share considerable genetic sequence similarity with humans being used as an animal model for various human disease conditions. The advantages comparison to other common vertebrate models include high fecundity, low cost, transparent embryos, rapid development. Due the spur interest research, need establish...
Microtubule-associated protein tau (MAPT) is abundant in neurons and functions assembly stabilization of microtubules to maintain cytoskeletal structure. Human MAPT transcripts undergo alternative splicing produce 3R 4R isoforms normally present at approximately equal levels the adult brain. Imbalance 3R-4R isoform ratio can affect microtubule binding may promote hyperphosphorylation neurofibrillary tangle formation as seen neurodegenerative diseases such frontotemporal dementia (FTD)...