A5019439819- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Cholinesterase and Neurodegenerative Diseases
- Menopause: Health Impacts and Treatments
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Phytoestrogen effects and research
- Tryptophan and brain disorders
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Zebrafish Biomedical Research Applications
- Prion Diseases and Protein Misfolding
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Trace Elements in Health
- Hypothalamic control of reproductive hormones
- Neurological Disease Mechanisms and Treatments
- Endoplasmic Reticulum Stress and Disease
- Neurological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Autophagy in Disease and Therapy
- Advanced Glycation End Products research
- Genetic Associations and Epidemiology
- Pomegranate: compositions and health benefits
Curtin University
2015-2024
Edith Cowan University
2014-2023
Bridge University
2023
King's College London
2023
Hollywood Private Hospital
2009-2020
Australian Alzheimer’s Research Foundation
2012-2019
KaRaMinds
2019
Western Sydney University
2019
The University of Western Australia
2009-2018
Hollywood Orthopaedic Group
2017
This protocol describes regular care and maintenance of a zebrafish laboratory. Zebrafish are now gaining popularity in genetics, pharmacological behavioural research. As vertebrate, share considerable genetic sequence similarity with humans being used as an animal model for various human disease conditions. The advantages comparison to other common vertebrate models include high fecundity, low cost, transparent embryos, rapid development. Due the spur interest research, need establish...
There is growing interest in using zebrafish (Danio rerio) as a model of neurodegenerative disorders such Alzheimer's disease. A tauopathies has recently been developed and characterized terms presence the pathological
Alzheimer's disease (AD) and type 2 diabetes (T2D) present a significant risk to each other. AD T2D are characterized by deposition of cerebral amyloid-β (Aβ) pancreatic human islet amyloid polypeptide (hIAPP), respectively. We investigated the role amyloidogenic proteins in interplay between these diseases. A novel double transgenic mouse model combining was generated characterized. AD-related mice coexpressing hIAPP displayed peripheral insulin resistance, hyperglycemia, glucose...
Hormonal changes associated with the dysregulation of hypothalamic-pituitary-gonadal (HPG) axis following menopause/andropause have been implicated in pathogenesis Alzheimer's disease (AD). Experimental support for this has come from studies demonstrating an increase amyloid-beta (Abeta) deposition ovariectomy/castration. Because sex steroids and gonadotropins are both part HPG feedback loop, any loss results a proportionate gonadotropins. To assess whether Abeta generation was due to serum...
We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer's disease (AD), both in terms of conservation genes involved AD and regulatory responses these to known risk factor - high cholesterol intake. Unlike rats mice, pigs possess an Aβ peptide sequence identical human Aβ. Consistent with commonality between cardiovascular factors humans, we saw that diet leads up-regulation BACE1 (β-secretase) transcription down-regulation ADAM10 (α-secretase) which should increase release...
Physical exercise interventions and cognitive training programs have individually been reported to improve cognition in the healthy elderly population; however, clinical significance of using a combined approach is currently lacking. This study evaluated whether physical activity (PA), computerized and/or combination both could cognition. In this nonrandomized study, 224 community-dwelling older adults (60–85 years) were assigned 16 weeks home-based PA (n=64), stimulation (n=62), (combined,...
Abstract Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases risk of developing dementia. Experimental from mouse models demonstrates induction T2D/insulin resistance (IR) can promote accumulation Alzheimer’s disease (AD) pathological features. However, association T2D with and clinical phenotypes in humans is unclear. Here we investigate relationship indices IR (HOMA-IR) pancreatic β-cell function (HOMA-B) cognitive performance across several domains (Verbal/Visual...
Reduction in testosterone levels men during aging is associated with cognitive decline and risk of dementia. Animal studies have shown benefits for supplementation improving cognition reducing Alzheimer's disease pathology. In a randomized, placebo-controlled, crossover study subjective memory complaint low levels, we investigated whether treatment significantly improved performance on various measures functioning. Forty-four were administered battery neuropsychological tests to establish...
Abstract Human pancreatic islet amyloid polypeptide (hIAPP) and beta (Aβ) can accumulate in Type 2 diabetes (T2D) Alzheimer’s disease (AD) brains evidence suggests that interaction between the two amyloidogenic proteins lead to formation of heterocomplex aggregates. However, structure consequences these complexes remains be determined. The main objective this study was characterise different types morphology Aβ-hIAPP heterocomplexes determine if such exacerbate neurotoxicity. We demonstrate...
Abstract Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their underlying biological mechanisms remain unclear. Here, we comprehensively assess the genetic relationship type 2 (T2D) GI disorders. Our study demonstrates a significant positive global correlation of T2D with peptic ulcer disease (PUD), irritable bowel syndrome (IBS), gastritis-duodenitis, gastroesophageal reflux (GERD), diverticular disease, but not inflammatory (IBD). We identify several local...