A5008216563- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Pain Management and Treatment
- Pain Mechanisms and Treatments
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Hormonal and reproductive studies
- Educational Curriculum and Learning Methods
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Public Health and Nutrition
- Advancements in Transdermal Drug Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Potassium and Related Disorders
- Diabetes Management and Research
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Decision Support System Applications
- Antioxidant Activity and Oxidative Stress
- Antimicrobial Peptides and Activities
- Medical Case Reports and Studies
- Hypothalamic control of reproductive hormones
- Multimedia Learning Systems
- Genetics and Physical Performance
- Genetics and Neurodevelopmental Disorders
The Kids Research Institute Australia
2022-2025
Murdoch University
2019-2023
Muhammadiyah University Purwokerto
2023
Edith Cowan University
2008-2018
Hollywood Private Hospital
2008-2011
The University of Western Australia
2008-2011
Pelita Harapan University
2011
We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer's disease (AD), both in terms of conservation genes involved AD and regulatory responses these to known risk factor - high cholesterol intake. Unlike rats mice, pigs possess an Aβ peptide sequence identical human Aβ. Consistent with commonality between cardiovascular factors humans, we saw that diet leads up-regulation BACE1 (β-secretase) transcription down-regulation ADAM10 (α-secretase) which should increase release...
This study explores the incidence of preoperative hypophosphatemia and whether may have affected patient or trial outcomes for those who received ferric carboxymaltose.
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer's disease and dementia. However, previous studies have contradictory. We assessed TRT physiological effects 44 (aged 61 ± 7.7 years) with subjective memory complaints using double blind, randomized, crossover, placebo-controlled study. Participants were randomized into 2 groups, one group received transdermal testosterone (50 mg) daily for 24 weeks, followed by 4 week...
The effect of testosterone on the levels Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated pigs (GPX) were administered at two different dosages, following which plasma and cerebrospinal
<i>Background/Aims:</i> Luteinizing hormone (LH) has been shown to alter the metabolism of beta amyloid (Aβ), a key protein in Alzheimer’s disease (AD) pathogenesis. While LH and components required for receptor signalling are present brain, their role CNS remains unclear. In vitro, facilitate neurosteroid production Aβ metabolism. However, whether can directly modulate cerebral levels vivo not previously studied. this study, we investigated effect chronic administration guinea...
Although the formation of β-amyloid (Aβ) deposits in brain is a hallmark Alzheimer disease (AD), soluble oligomers rather than mature amyloid fibrils most likely contribute to Aβ toxicity and neurodegeneration. Thus, discovery agents targeting highly desirable for early diagnosis prior manifestation clinical AD phenotype also more effective therapies. We have previously reported that novel 15-amino acid peptide (15-mer), isolated via phage display screening, targeted attenuated its...
Persistent regional and systemic inflammation may promote pain hyperalgesia in complex syndrome (CRPS). In this study, we investigated whether stimulation of α
Accumulation of beta amyloid (Aβ) in the brain is a primary feature Alzheimer’s disease (AD) but exact molecular mechanisms by which Aβ exerts its toxic actions are not yet entirely clear. We documented pathological changes 3 and 6 months after localised injection recombinant, bi-cistronic adeno-associated viral vectors (rAAV2) expressing human Aβ40-GFP, Aβ42-GFP, C100-GFP or C100V717F-GFP into hippocampus cerebellum 8 week old male mice. Injection all rAAV2 resulted wide-spread transduction...
Alpha-1 adrenoceptors are overexpressed in the epidermis of a subgroup patients with complex regional pain syndrome (CRPS). Activating α 1 -adrenoceptors epidermal cells increases production proinflammatory cytokine interleukin-6 (IL-6), mediator inflammation. To investigate whether this might exacerbate inflammation CRPS, primary keratinocytes or dermal fibroblasts were cultured from skin biopsies obtained affected limb 25 and similar site 28 controls. The fundamental cytokine, tumor...
Abstract Baculoviral protein expression in insect cells has been previously used to generate large quantities of a interest for subsequent use biochemical and structural analyses. The MultiBac baculovirus system enabled, the single reconstitute complex interest, resulting larger yield. Using this system, we aimed reconstruct gamma (γ)-secretase complex, multiprotein enzyme essential production amyloid-β (Aβ) protein. A vector containing all components γ-secretase was generated observed...
Treatment of tuberculosis with main anti-tuberculosis drugs (OAT) includes isoniazid (INH), rifampin (RIF), ethambutanol (EMB), streptomycin (SM), and pyrazinamide (PZA). Although most Anti-Tuberculosis Drugs are acceptable in therapy, they have potential side effects, including the effects hematological reactions such as anemia. This study's purpose was to compare HB levels before after intensive phase treatment TB patients at Petanahan Public Health Care Center, Kebumen Regency. an...
The purpose of this investigation was to assess the acute changes in growth factors associated with cognitive health following two ecologically valid, intense resistance exercise sessions. Twenty-nine late-middle-aged adults performed one session either (a) moderate-load or (b) high-load exercise. Venous blood collected prior warm-up, immediately and 30 min Serum analyzed for brain-derived neurotrophic factor, insulin-like factor 1, vascular endothelial factor. Session intensity determined...
The peripheral sink hypothesis maintains that the concentration gradient from brain to periphery influences accumulation of Aß in brain. Previously, our lab has shown majority circulating is degraded by liver a process dependant on APOE genotype. Thus e4 TR mice show significantly delayed clearance compared e2 and e3 mice. Variations total plasma cholesterol can lead up-regulation transcription. Therefore, it been suggested alterations metabolism may increase risk for AD due, part,...
The rise in luteinizing hormone (LH) concentration during senescence has been associated with increased risk of developing Alzheimer's disease (AD). LH shown to modulate the amyloidogenic processing amyloid precursor protein (APP). receptor (LHR) localised limbic system, particular hippocampus, area that is devastated AD. Therefore, we administered either or placebo containing slow-release pellets within cortex castrated guinea pigs, where amyloid-beta (Aβ) sequence identical human,...
We investigated the guinea pig, Cavia porcellus, as a model for late-onset Alzheimer's disease, LOAD, both in terms of conservation genes involved disease (AD) and regulatory responses these to known AD risk factor - high cholesterol intake. Unlike rats mice, pigs possess an Aβ peptide sequence identical human Aβ. Significantly, also isoforms other AD-related found humans that are not present mice or rats. Sequence alignments proteins between common rodent models (i.e. pigs, rats) were made....