A5077971641- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Advanced Drug Delivery Systems
- Pharmacological Effects and Toxicity Studies
- Fatty Acid Research and Health
- Barrier Structure and Function Studies
- Advancements in Transdermal Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Trace Elements in Health
- Climate change and permafrost
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- RNA Interference and Gene Delivery
- Amyotrophic Lateral Sclerosis Research
- Nanoparticle-Based Drug Delivery
- Landslides and related hazards
- Neuropeptides and Animal Physiology
- Drug Solubulity and Delivery Systems
- Cholesterol and Lipid Metabolism
- Diet and metabolism studies
- S100 Proteins and Annexins
- Amino Acid Enzymes and Metabolism
- Antibiotic Resistance in Bacteria
- Geological Studies and Exploration
Monash University
2016-2025
Australian Regenerative Medicine Institute
2025
NAACP Legal Defense and Educational Fund
2007-2021
To assess the role of kynurenine pathway in pathology Alzheimer's disease (AD), expression and localization key components including regulatory enzyme tryptophan 2,3 dioxygenase (TDO), metabolites tryptophan, kynurenine, kynurenic acid, quinolinic acid picolinic were assessed different brain regions triple transgenic AD mice. The cell distribution TDO their co-localization with neurofibrillary tangles senile β amyloid deposition also determined hippocampal sections from human brains. mRNA...
The brain has a limited ability to synthesize the essential polyunsaturated fatty acid (PUFA) docosahexaenoic (DHA) from its omega-3 precursors. Therefore, maintain concentrations of this PUFA at physiological levels, plasma-derived DHA must be transported across blood-brain barrier (BBB). While is able partition into luminal membrane endothelial cells, low aqueous solubility likely limits cytosolic transfer abluminal membrane, necessitating requirement an intracellular carrier protein...
Exercise improves cognitive function in Alzheimer's disease (AD) via mechanism that are not fully clear. Here, we first examined the effect of voluntary exercise training (VET) on energy metabolism and APP/PS1 transgenic mouse (Tg) model familial AD. Next, profiled extracellular vesicles (EVs) whether they may play a role protective effects VET intranasal administration EVs, purified from blood sedentary (sEV) and/or acutely exercised (eEV) donor wild-type mice into APP/PS1Tg mice. We show...
Fatty acid-binding protein 5 (FABP5) at the blood–brain barrier contributes to brain uptake of docosahexaenoic acid (DHA), a blood-derived polyunsaturated fatty essential for maintenance cognitive function. Given importance DHA in cognition, aim this study was investigate whether deletion FABP5 results dysfunction and is associated with reduced endothelial cell exogenous subsequent attenuation levels endogenous DHA. Cognitive function assessed male female +/+ −/− mice using battery memory...
Memantine (MEM) is prescribed in mono and combination therapies for treating the symptoms of moderate to severe Alzheimer's disease (AD). Despite MEM being widely with other AD non-AD medicines, very little known about its mechanism transport across blood-brain barrier (BBB), whether nature this lends a potential drug-drug interactions at BBB. Therefore, purpose study was characterize mechanisms facilitating brain uptake Swiss Outbred mice using an situ transcardiac perfusion technique,...
Therapeutic monoclonal antibodies are currently delivered mainly via the intravenous route, since large volumes often required to deliver a therapeutic dose. Administration subcutaneous route would have several advantages; absorption mechanisms for dosed subcutaneously poorly understood. This study was conducted develop better understanding of governing and trafficking antibodies. Specifically, role lymphatic system in prolonged plasma exposure trastuzumab explored thoracic lymph...
Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial memory accelerate learning in a number paradigms. Using virtual screening approach, series benzopyran compounds was identified that inhibited the catalytic activity IRAP, ultimately resulting identification potent specific inhibitors. The present study describes medicinal chemistry campaign led to development lead candidate, 3, highlighting key structural features considered as critical for...
Abstract Prolonged activation of microglia leads to excessive release proinflammatory mediators, which are detrimental brain health. Therefore, there significant efforts identify pathways mediating microglial activation. Recent studies have demonstrated that fatty acid-binding protein 4 (FABP4), a lipid binding protein, is critical player in macrophage–mediated inflammation. Given we previously identified FABP4 microglia, the aim this study was assess whether activity contributed...