A5017068697- Mycotoxins in Agriculture and Food
- Wheat and Barley Genetics and Pathology
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Plant Disease Resistance and Genetics
- Pesticide Residue Analysis and Safety
- Hormonal and reproductive studies
- Plant and fungal interactions
- Plant Pathogens and Resistance
- Stress Responses and Cortisol
- Phytoestrogen effects and research
- Antioxidant Activity and Oxidative Stress
- Bacillus and Francisella bacterial research
- Toxin Mechanisms and Immunotoxins
- Sodium Intake and Health
- Monoclonal and Polyclonal Antibodies Research
- Estrogen and related hormone effects
- Selenium in Biological Systems
- Food Industry and Aquatic Biology
- Insect and Pesticide Research
- Analytical chemistry methods development
- Plant Toxicity and Pharmacological Properties
- Carcinogens and Genotoxicity Assessment
- Pharmacological Effects and Assays
- Advanced biosensing and bioanalysis techniques
Teagasc - The Irish Agriculture and Food Development Authority
2021-2023
Ghent University
2015-2020
Cancer Research Institute Ghent
2020
Edith Cowan University
2008-2015
The University of Western Australia
2008-2015
Hollywood Private Hospital
2008-2011
Australian Alzheimer’s Research Foundation
2008-2009
Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD) and has been postulated as potential biomarker for AD. However, there is lack consensus to its suitability an AD biomarker. The objective this study w
The European Food Consumption Validation (EFCOVAL) project includes 600 men and women from Belgium, the Czech Republic, France, Netherlands, Norway, who had given serum 24-hour urine samples, completed dietary recall (24-HDR) interviews. Consumption, according to 24-HDR, was matched against Safety Authority (EFSA) databases of mycotoxin contaminations, via FoodEx1 standard classifications, producing an indirect external estimate exposure. Direct, internal measurements exposure were made in...
To explore differences of zearalenone (ZEN) metabolism between various species, phase I and II by liver microsomes animals human were investigated using ultra high-pressure liquid chromatography-quadrupole/time-of-flight mass spectrometry (UHPLC-Q/TOF MS). A total 24 metabolites identified, among which 12 reported for the first time. Reduction, hydroxylation, glucuronidation major metabolic pathways ZEN, significant in species also observed. Reduction was main reaction swine human, whereas...
The natural co-occurrence of 42 mycotoxins was investigated in unprocessed oat grains grown Ireland. sample set included a total 208 crops harvested during 2015–2016 and produced using conventional, organic, or gluten free farming systems. A range different toxins identified, including the major type (neosolaniol, HT-2 T-2 toxins, triol, T-2-glucoside, co-occurring 21 samples) B trichothecenes (deoxynivalenol, nivalenol, deoxynivalenol-3-glucoside), enniatins (B1, B, A1, 12 samples), as well...
Dysregulation of the hypothalamic pituitary gonadal (HPG) axis during aging has been associated with increased risk cognitive decline and developing dementia. Compared to controls, men Alzheimer's disease (AD) have shown lower se
A rapid method for the liquid chromatography-tandem mass spectrometric determination of type and B trichothecenes their major metabolites in chicken meat, pork, liver, swine liver was developed. The analytes included T-2 toxin, HT-2 triol, neosolaniol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxydeoxynivalenol, nivalenol. compounds were extracted from samples with acetonitrile/ethyl acetate (1:3, v/v) then cleaned up using Oasis HLB cartridges. Analysis carried...
After being incubated with animal and human liver microsomes, metabolites of phase I II were investigated. A comparison was performed by ultrahigh performance liquid chromatography-quadrupole/time-of-flight coupled to mass spectrometry (UHPLC-Q/TOF). Consequently, a total four three glucuronide binding T-2 toxin discovered. Although significant metabolic difference observed among six species, HT-2 the major product in all species. In addition, vivo metabolism after oral administration also...
Testosterone replacement therapy (TRT) has been investigated in older men as a preventative treatment against Alzheimer's disease and dementia. However, previous studies have contradictory. We assessed TRT physiological effects 44 (aged 61 ± 7.7 years) with subjective memory complaints using double blind, randomized, crossover, placebo-controlled study. Participants were randomized into 2 groups, one group received transdermal testosterone (50 mg) daily for 24 weeks, followed by 4 week...
The effect of testosterone on the levels Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated pigs (GPX) were administered at two different dosages, following which plasma and cerebrospinal
<i>Background/Aims:</i> Luteinizing hormone (LH) has been shown to alter the metabolism of beta amyloid (Aβ), a key protein in Alzheimer’s disease (AD) pathogenesis. While LH and components required for receptor signalling are present brain, their role CNS remains unclear. In vitro, facilitate neurosteroid production Aβ metabolism. However, whether can directly modulate cerebral levels vivo not previously studied. this study, we investigated effect chronic administration guinea...
Seven agronomic factors (crop season, farming system, harvest date, moisture, county, oat variety, and previous crop) were recorded for 202 crops grown across Ireland, samples analysed by LC-MS/MS four major
Seven agronomic factors (crop season, farming system, harvest date, moisture, county, oat variety, and previous crop) were recorded for 202 crops grown across Ireland, samples analysed by LC-MS/MS four major Fusarium mycotoxins: deoxynivalenol (DON), zearalenone (ZEN), T-2 toxin HT-2 toxin. Type A trichothecenes present in 62% of crops, with 7.4% exceeding European regulatory limits. DON (6.4%) ZEN (9.9%) occurrences rela-tively infrequent, though one three measured over their set limits...
Nitrovin (NTV) belongs to a class of antibiotics called nitrofurans, which are classified as nonallowed pharmacologically active substances that do not have maximum residue limit listed in EU legislation. The objectives this study were confirm aminoguanidine (AGN) suitable marker monitor NTV abuse and investigate its persistence porcine tissues. In work, pigs fed with NTV-medicated feed (50 mg/kg), tissues (kidney, muscle, liver) plasma collected on different withdrawal days. All samples...
Mycotoxins are among the most alarming food and feed contaminants threatening human animal health.Since discovery of aflatoxins in 1960s, body knowledge field mycotoxins increased dramatically: biological syntheses have been unraveled; myriad analytical detection methods were developed; surveys different matrices conducted; investigations into toxicities took place; several for control tested; legislative debates to protect public from their toxic effects continue.Based on that, hundreds...
The relationship between brain-derived neurotrophic factor (BDNF) and Alzheimer's disease (AD) pathogenesis is yet to be fully elucidated. BDNF critical for neuronal survival function represents a potential neuroprotective agent; somewhat expectedly, low levels have been measured in the AD brain post mortem. However, conflicting results reported blood fractions of patients, possibly reflecting differences stage or measurement technique. These ‘conflicting results’ make it difficult determine...