A5057131061- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Spinal Fractures and Fixation Techniques
- Cytokine Signaling Pathways and Interactions
- RNA Interference and Gene Delivery
- Gastroesophageal reflux and treatments
- Liver Disease Diagnosis and Treatment
- Alzheimer's disease research and treatments
- interferon and immune responses
- Immunotherapy and Immune Responses
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Esophageal and GI Pathology
- Flavonoids in Medical Research
- Management of metastatic bone disease
Versus Arthritis
2023-2025
University of Manchester
2023-2025
Beijing HuiLongGuan Hospital
2025
Genomics (United Kingdom)
2024
Guangzhou Institutes of Biomedicine and Health
2014-2022
Guangzhou Medical University
2017-2022
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2020-2021
Chinese Academy of Sciences
2014-2021
University of Chinese Academy of Sciences
2020
University of California, Los Angeles
2001-2013
Osteoarthritis is a complex disease with huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organisation in three-dimensional (3D) space essential for identifying long-range contacts between distant genomic features (e.g., and regulatory elements), tissue-specific manner. Here, we generate first whole genome...
Accumulation of amyloid beta-peptides (Abeta) in the brain has been linked with memory loss Alzheimer's disease and its animal models. However, synaptic mechanism by which Abeta causes deficits remains unclear. We previously showed that acute application inhibited long-term potentiation (LTP) hippocampal perforant path via activation calcineurin, a Ca2+ -dependent protein phosphatase. This study examined whether could also inhibit Ca2+/calmodulin dependent kinase II (CaMKII), further...
Amyloid-β (Aβ) peptide-induced impairment of hippocampal synaptic plasticity is considered an underlying mechanism for memory loss in the early stages Alzheimer's disease and its animal models. We previously reported inhibition long-term potent
BACKGROUND.: A neutrophil elastase (NE) inhibitor, Sivelestat, has been approved for the treatment of acute lung injury associated with systemic inflammation in humans. Some reports have also shown its protective effects liver inflammatory states. We recently documented importance NE pathophysiology ischemia/reperfusion injury, a local Ag-independent response. This study was designed to explore putative cytoprotective functions clinically available Sivelestat injury. METHODS.: Partial warm...
Somatic cell reprogramming is accompanied by changes in lipid metabolism. While attempting to dissect the molecular mechanisms of metabolic switch during reprogramming, we found that overexpression sterol regulatory element binding protein-1 (Srebp-1), a transcriptional factor required for homeostasis, enhances efficiency, while knockdown or pharmaceutical inhibition Srebp-1 inhibitory. blocks formation partially reprogrammed cells, and functions early phase reprogramming. Furthermore,...
The T cell immunoglobulin and mucin domain-containing molecules (TIM) protein family, which is expressed by cells, plays a crucial role in regulating host adaptive immunity tolerance. However, its local inflammation, such as innate immunity-dominated organ ischemia–reperfusion injury (IRI), remains unknown. Liver IRI occurs frequently after major hepatic resection or liver transplantation. Using an antagonistic anti–TIM-1 antibody (Ab), we studied the of TIM-1 signaling model partial warm...
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and third leading cause of cancer death worldwide. Recently, multitargeted kinase inhibitor sorafenib was shown to be first systemic agent improve survival in advanced HCC. Unlike other malignancies such as breast cancer, which molecular subtypes have been clearly defined (i.e., luminal, HER2 amplified, basal, etc.) tied effective therapeutics (hormone blockade trastuzumab, respectively), HCC this translational link does not...
Neutrophils are considered crucial effector cells in the pathophysiology of organ ischemia/reperfusion injury (IRI). Although neutrophil elastase (NE) accounts for a substantial portion activity, function NE liver IRI remains unclear. This study focuses on role mechanism IRI. Partial warm ischemia was produced left and middle hepatic lobes C57BL/6 mice 90 minutes, this followed by 6 to 24 hours reperfusion. Mice were treated with inhibitor (NEI; 2 mg/kg per os) at 60 minutes prior insult....
Genome-wide association studies (GWAS) have uncovered the genetic basis behind many diseases and conditions. However, most of these loci affect regulatory regions, making interpretation challenging. Chromatin conformation has a fundamental role in gene regulation is frequently used to associate potential target genes regions. previous mostly small sample sizes immortalized cell lines instead primary cells. Here we present extensive dataset chromatin with matching expression accessibility...
Colorectal adenomas (CRA) exhibit high recurrence rates following endoscopic resection. Insulin resistance (IR) and chronic inflammation, increasingly prevalent due to unhealthy lifestyles, are key factors in CRA development. This study aimed evaluate the predictive power of combining inflammation score with triglyceride-glucose (TyG) index for recurrence. We conducted a comprehensive analysis clinical characteristics 847 patients who underwent Postoperative was assessed using logistic...
Objective Genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with juvenile idiopathic arthritis (JIA), the majority of which are located in non-coding regions such as enhancers. This presents a challenge for pinpointing causal variants and their target genes. Interpreting these loci requires functional genomics data from disease-relevant tissues, has been lacking JIA. study seeks to fill that gap elucidate biological mechanisms...
Mammalian spermatogenesis is regulated by coordinated gene expression in a spatiotemporal manner. The regulation of major sperm proteins plays important roles during normal development the male gamete, which underlying molecular mechanisms are poorly understood. A-kinase anchoring protein 3 (AKAP3) one components fibrous sheath tail that formed spermiogenesis. In present study, we analyzed sperm-specific Akap3 and potential regulatory factors its synthesis mouse Results showed transcription...
Abstract Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer death world-wide. Sorafenib, multi-targeted small molecule inhibitor the vascular endothelial growth factor (VEGF) receptor and other kinases only approved systemic agent in advanced HCC. Despite multiple studies defining molecular heterogeneity HCC, clinical trials new agents do not pre-select for predictive markers. The fibroblast (FGF) consists 4 tyrosine over 20 ligands. Differential expression activation...
ABSTRACT In this study, we present the most extensive dataset of chromatin conformation data with matching gene expression and accessibility from primary T cells to date. We use enhance our understanding different mechanisms by which GWAS variants impact regulation revealing how natural genetic variation alter structure in at an unprecedented scale. Capitalizing on vast dataset, refine mapping loci implicated regulatory elements, such as CTCF binding sites other enhancer aiding assignment....
Background. We have shown that treatment with molecularly engineered, allochimeric [α1 hl/u]-RT1.Aa class I MHC antigens bearing donor-type Wistar-Furth (WF, RT1.Au) amino acid substitutions for host-type ACI (RTI.Aa) sequences in the α1-helical region induces donor-specific tolerance to cardiac allografts rat recipients. This study examined effect of molecules on development chronic rejection. Methods. Allochimeric antigenic extracts (1 mg) were administered via portal vein into recipients...