A5101983656- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Enterobacteriaceae and Cronobacter Research
- Sleep and related disorders
- Biological and pharmacological studies of plants
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Ferroptosis and cancer prognosis
- Milk Quality and Mastitis in Dairy Cows
- Cancer Mechanisms and Therapy
- Liver physiology and pathology
- Medicinal Plants and Bioactive Compounds
- Hedgehog Signaling Pathway Studies
- Synthesis and Biological Activity
- Redox biology and oxidative stress
- Natural product bioactivities and synthesis
- Antibiotic Resistance in Bacteria
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Constructed Wetlands for Wastewater Treatment
- Exercise and Physiological Responses
- RNA modifications and cancer
Beijing HuiLongGuan Hospital
2025
Shantou University
2024
Shantou University Medical College
2024
Tongji University
2014-2024
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2024
University of Electronic Science and Technology of China
2024
Shanghai Tenth People's Hospital
2014-2024
Jiaxing University
2019-2022
Nanjing General Hospital of Nanjing Military Command
2022
Zhejiang University
2014-2021
Immunosuppressive tumor microenvironment (ITM) remains an obstacle that jeopardizes clinical immunotherapy.
Abstract Liver fibrosis is a major risk factor for hepatocellular carcinoma origin, and its progression not only correlates with oxidative stress inflammation, but also encouraged by autophagy hold‐up. Therefore, new solutions to effectively attenuate inflammation coincidently favor are highly demanded reverse liver fibrosis, even hamper escalation into carcinoma. Herein, the porous manganese‐substituted Prussian blue (PMPB) analogs harnessed activate autophagy, scavenge reactive oxygen...
Tripartite motif-containing 59 (TRIM59) belongs to the tripartite motif (TRIM) protein family and is upregulated in various malignancies. However, its expression colorectal cancer (CRC) still unknown. In present study, we examined biological function of TRIM59 CRC. We analyzed CRC tissues cells by quantitative real-time polymerase chain reaction. Kaplan-Meier survival analysis was used evaluate prognostic significance patients. Furthermore, investigated role growth metastasis. The potential...
Colorectal cancer(CRC) is one of the most commonly diagnosed cancers in human beings and metastasis main death reason. Recently, Gli1 has been reported to be a key regulator various cancer biologies genes expressions. However, detailed molecular mechanism CRC remains largely unknown. In this study, we aimed investigate role metastasis. We used qRT-PCR, Immunohistochemistry Western blot test expression levels Gli1, Foxm1 other target tissues cells; Lentivirus stable transfection change Foxm1;...
Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a heterogeneous entity varying underlying etiologies and occurs in ~5-10% of patients acute myocardial infarction. Sleep disorders short sleep duration are common phenomena experienced by heart disease associated poor clinical outcomes. However, the association between quality, duration, MINOCA prognosis less clear.We performed prospective observational study 607 February 2016 June 2018. The mean follow-up period was...
Abstract Colorectal cancer ( CRC ) is the third most common worldwide and liver metastases are leading cause of death in patients with . In this study, we performed next‐generation sequencing profiling on primary colorectal tumor tissues obtained from three without to identify differentially expressed genes DEG s) that might be responsible for process. After filtering 2690 s, comprising 996 upregulated 1694 downregulated RNA 22 73 s were identified. Gene ontology GO pathway analyses...
Colorectal adenomas (CRA) exhibit high recurrence rates following endoscopic resection. Insulin resistance (IR) and chronic inflammation, increasingly prevalent due to unhealthy lifestyles, are key factors in CRA development. This study aimed evaluate the predictive power of combining inflammation score with triglyceride-glucose (TyG) index for recurrence. We conducted a comprehensive analysis clinical characteristics 847 patients who underwent Postoperative was assessed using logistic...
Vasculogenic mimicry (VM) describes the formation of an epithelial-independent tumor microcirculation system that differs from traditional angiogenesis. Angiogenesis and VM are closely related through cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) pathway epithelial-mesenchymal transition (EMT) process.In this study, 8-Br-cAMP, a cAMP analog PKA activator, was used to activate cAMP/PKA evaluate effects on angiogenesis in colorectal cancer (CRC) cells. We syngeneic model CRC...
Rhodioloside, the main effective constituent of Rhodiola rosea , demonstrates antiaging and antioxidative stress functions inhibits calcium overloading in cells. These imply that rhodioloside may exert protective effects on hippocampal neurons after total cerebral ischemia/reperfusion injury. In this study, male Wistar rat models ischemia were constructed randomly divided into four groups: sham-operation, ischemia/reperfusion, low-dosage, high-dosage groups. The result showed treatment...
Current embolic agents in transcatheter arterial chemoembolization (TACE) of hepatocellular carcinoma (HCC) encounter instability and easy leakage, discounting TACE efficacy with residual HCC. Moreover, clinical aggravates hypoxia pro-metastatic microenvironments, rendering patients HCC poor prognosis.
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear. Methods: Rat depression chronic unpredictable stress was constructed, body weight of rats measured. The efficacy REMSD on pleasure experience, exploration, cognition with determined by Sucrose preference test, open field Morris water task, respectively. effects depression-induced damage apoptosis in rat hippocampi detected using hematoxylin–eosin...
Background Management of bone cancer pain is difficult because its complex mechanisms, which has a major impact on the quality patients’ daily life. Recent studies have indicated that endoplasmic reticulum stress involved in many neurological and inflammatory pathways associated with pain. However, factors contribute to causes are still unknown. In this study, we examined whether response caspase signaling pathway-dependent apoptosis neurons spinal dorsal horn tumor-bearing rats it thereby...
Abstract Background Lung cancer (LC) is one of the most common cancers and a leading cause cancer‐related deaths worldwide. In many pathological conditions, particularly in tumor microenvironment, cells tissues frequently exist hypoxic state. Here, we evaluated Itchy E3 ubiquitin protein ligase (ITCH) expression LC following hypoxia treatment. Methods cell lines were treated with condition. Cell migration, invasion, inflammation, reactive oxygen species (ROS) production, apoptosis determined...
Raf kinase inhibitory protein (RKIP) is a well-established metastasis suppressor that frequently down-regulated in aggressive cancers. However, the impact of RKIP on cancer cell invasion and prostate still elusive. To this end, we overexpressed two lines. We found overexpression inhibited cells proliferation, migration invasion. Mechanistically, led to down-regula- tion NF-kB signaling pathway inhibition epithelial-to-mesenchymal transition, which important step for metastasis. In addition,...