A5036361995- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Genomics and Phylogenetic Studies
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Colorectal and Anal Carcinomas
- Acute Myeloid Leukemia Research
- Geomagnetism and Paleomagnetism Studies
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Photochromic and Fluorescence Chemistry
- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Origins and Evolution of Life
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- Parasitic infections in humans and animals
- Lung Cancer Research Studies
Southern Medical University
2025
Nanfang Hospital
2025
Shantou University
2010-2024
MRC Laboratory of Molecular Biology
2021-2024
Shantou University Medical College
2010-2024
Shandong Eye Hospital
2024
Shandong First Medical University
2024
Chengde Medical University
2016-2023
First Affiliated Hospital of GuangXi Medical University
2023
Guangxi Medical University
2023
Purpose: To identify tumor-derived exosomal biomarkers that are able to discriminate between adenocarcinoma and squamous cell carcinoma (SCC) as a noninvasive method in the early diagnosis of non-small lung cancer (NSCLC).Experimental Design: Tumor-derived exosomes from plasma early-stage NSCLC patients were isolated. Exosomal miRNA profiling 46 stage I 42 healthy individuals was performed using miRNA-seq validate adenocarcinoma- SCC-specific miRNAs. The diagnostic accuracy select miRNAs...
Numerous enzymes hyperphosphorylate Tau in vivo, leading to the formation of neurofibrillary tangles (NFTs) neurons Alzheimer's disease (AD). Compared with age-matched normal controls, we demonstrated here that protein levels WW domain-containing oxidoreductase WOX1 (also known as WWOX or FOR), its Tyr33-phosphorylated form, and WOX2 were significantly down-regulated AD hippocampi. Remarkably knock-down expression by small interfering RNA neuroblastoma SK-N-SH cells spontaneously induced...
Abstract Background and objectives The survival rate of patients with advanced oesophageal cancer is very low can vary significantly, even among the same TNM stage. It important to look for indicators that are economical readily available predict overall survival. aim this study was determine whether lymphocyte-to-monocyte ratio (LMR) neutrophil-to-lymphocyte (NLR) could be potential predictors in squamous cell carcinoma (ESCC) undergoing concurrent chemoradiotherapy. Methods Differences 204...
Heat stress, a major abiotic stressor of wheat (Triticum aestivum L.), often results in reduced yield and decreased quality. In this study, proteomic method, Tags for Relative Absolute Quantitation Isobaric (iTRAQ), was adopted to analyze the protein expression profile changes among cultivar Jing411 under heat stress. Results indicated that there were 256 different proteins expressed According result gene annotation functional classification, 239 annotated by 856 GO function entries,...
5-Formyl-2'-deoxycytosine (fdC) is a recently discovered epigenetic base in the genome of stem cells, with yet unknown functions. Sequencing data show that enriched CpG islands promoters and hence likely involved regulation transcription during cellular differentiation. fdC known to be recognized excised by enzyme thymine-DNA-glycosylase (Tdg). As such, believed function as an intermediate active demethylation. In order understand new fdC, it important analyze its formation removal at...
Protein-catalyzed aminoacylation of the 3′-overhang tRNA by an aminoacyl-adenylate could not have taken place prior to advent genetically coded peptide synthesis, and yet latter process has absolute requirement for aminoacyl-tRNA. There must therefore been earlier nonprotein-catalyzed means generating Here, we demonstrate efficient interstrand aminoacyl transfer from phosphate mixed anhydride at 5′-terminus a acceptor stem mimic 2′,3′-diol terminus short 3′-overhang. With certain five-base...
The encoding step of translation involves attachment amino acids to cognate tRNAs by aminoacyl-tRNA synthetases, themselves the product coded peptide synthesis. So, question arises─before these enzymes evolved, how were primordial selectively aminoacylated? Here, we demonstrate enzyme-free, sequence-dependent, chemoselective aminoacylation RNA. We investigated two potentially prebiotic routes acceptor stem-overhang mimics and analyzed those oligonucleotides undergoing most efficient...
The traditional view that immunoglobulin (Ig) is produced only by B lymphocytes has been challenged, because it demonstrated Ig genes and proteins are expressed in epithelial cancer cells. However, whether expression nonlymphoid cells limited to unclear. Because sarcomas differ distinctly from carcinomas their biologic clinical features, the authors investigated question of IgG soft tissue lesions.Immunohistochemistry, situ hybridization, polymerase chain reaction (PCR) were used demonstrate...
The aim of this study was to determine the prognostic factors and their significance in gastric cancer (GC) patients, using artificial neural network (ANN) Cox regression hazard (CPH) models. A retrospective analysis undertaken, including 289 patients with GC who had undergone gastrectomy between 2006 2007. According CPH analysis, disease stage, peritoneal dissemination, radical surgery body mass index (BMI) were selected as significant variables. ANN model, surgery, serum CA19-9 levels,...
The DNA structure is an ideal building block for the construction of functional nano-objects. In this direction, metal coordinating base pairs (ligandosides) are appealing tool future specific functionalization such We present here a study, in which we combine ion pyrazole ligandoside with interstrand crosslinking salen system. show that both ligandosides, when combined, able to create stable multi-copper complexing double helix structures cooperative fashion.
Human cardiac stem/progenitor cells and their potential for repair of heart injury are a current hot topic research. CD117 has been used frequently as marker identification in the heart. However, mast cells, which also CD117(+), have not excluded by credible means when selecting putative progenitors using marker. We evaluated relationship between CD117(+) left ventricle human hearts (n=5 patients, ages 1 week-75 years) with well-established cell markers tryptase, toluidine blue, thionine. A...
Caged antisense oligodeoxynucleotides (asODNs) are synthesized by linking two ends of linear using a photocleavable linker. Two them (H30 and H40) have hairpin-like structures which show large difference in thermal stability (Delta T(m) = 17.5 degrees C 11.6 C) comparing to uncaged ones. The other three (C20, C30 C40) without stable secondary the middle 20 deoxynucleotides complementary 40-mer RNA. All caged asODNs restricted opening provides control over RNA/asODN interaction. RNase H assay...
Abstract Background Excision repair cross-complementing group 1 (ERCC1) and 2 (ERCC2), X-ray (XRCC1) proteins play important roles in the of DNA damage adducts. Single nucleotide polymorphisms (SNPs) genes are suspected to influence treatment effect survival cancer patients. This study aimed investigate relationship between ERCC2 , ERCC1 XRCC1 non-smoking female patients with lung adenocarcinoma. Methods We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
Background: Recent studies have shown that USP13 a deubiquitinase, serves as an important regulator of tumorigenesis. However, the biological role in oral squamous cell carcinoma (OSCC) remains enigmatic. Materials and methods: We examined expression OSCC adjacent normal tissues by immunohistochemical staining. The functions cells possible underlying mechanisms were investigated. Results: In this study, we showed was frequently reduced human specimens reduction correlated with clinical...
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Abstract Background Excision repair cross-complementing group 1 (ERCC1) and 2 (ERCC2) proteins play important roles in the of DNA damage adducts. Single nucleotide polymorphisms (SNPs) genes are suspected to influence risk lung cancer. This study aimed investigate association between ERCC2 751, 312 ERCC1 118 adenocarcinoma Chinese non-smoking females. Methods A hospital-based case-control 285 patients matched controls was conducted. Information concerning demographic factors obtained for...
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. 5-Fluorouracil (5-Fu) important chemotherapeutic drug used for treatment of CRC. However, resistance to 5-Fu therapies a growing concern in CRC clinical practice recently. Andrographolide (Andro) main bioactive constituent herb Andrographis paniculata, which has various biological effects including anti-inflammation and antitumor activities. In present study, we investigated combined Andro with against HCT-116...
Wheat (Triticum aestivum L.) is one of the three major global food crops. High-temperature stress can affect its yield and quality. Studies effect high-temperature on wheat kernel development are important because they reveal stability quality lead to genetic improvement traits. In this study, isobaric tags for relative absolute quantitation (iTRAQ) method was adopted analyze changes in protein expression profile cultivars under high temperature stress. The content grain increased heat...
Nuclear receptor interacting protein (NRIP1), also known as RIP140, is a transcriptional co-regulator required for the maintenance of energy homeostasis and ovulation.Although several studies have identified roles NRIP1 in various cell processes, biological functions esophageal squamous carcinoma (ESCC) remain unknown.Herein, we demonstrate that inhibits migration invasion ESCC cells.Further mechanistic revealed directly targeted by miR-548-3p miR-576-5p.We then miR-576-5p regulate cells...
Abstract We report the development of a new heterobase that is held together through reversible bonding. The so‐formed cross‐link adds strong stabilization to DNA duplex. Despite this, opens and closes imine Moreover, even enzymatic incorporation possible. principle can be used stabilize duplexes nanostructures otherwise require high salt concentrations, which may hinder biological applications.
Background:The rates of locoregional and distant recurrence for esophageal squamous cell carcinoma (ESCC) patients underwent radical esophagectomy remain high.The purpose this study is to explore an optimal postoperative therapeutic modality by investigating the efficacy various adjuvant therapies in treatment ESCC.Methods: We retrospectively reviewed 408 ESCC thoracic 3-field lymph node dissection from 2010 2015.Patients were classified into surgery alone (Group S), chemotherapy CT) plus...