A5049679155- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Viral Infections and Outbreaks Research
- Pancreatic function and diabetes
- Viral Infections and Vectors
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- Groundwater and Isotope Geochemistry
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- SARS-CoV-2 detection and testing
- Blood groups and transfusion
Academy of Military Medical Sciences
2018-2025
Beijing VDJBio (China)
2025
Guizhou Normal University
2024
Czech Academy of Sciences, Institute of Biotechnology
2024
Biotechnology Institute
2024
Guizhou University
2020-2023
University of Southern California
2018-2023
Los Angeles Medical Center
2023
University of California, Los Angeles
2022-2023
Kaiser Permanente Riverside Medical Center
2022-2023
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on receptor binding domain (RBD) Spike (S) protein but also across full protein. We isolated and characterized monoclonal antibodies (mAbs) from 10 convalescent COVID-19 patients. Three mAbs showed neutralizing activities authentic SARS-CoV-2. One mAb, named 4A8, exhibits high neutralization potency both pseudotyped SARS-CoV-2 does bind RBD....
Significance Accumulated data show that circadian rhythms act as important regulators of specific immune functions, including activities Toll-like receptor 9, macrophages, and Interleukin-17–producing CD4 + T helper (T H 17) cells. In this study, we mice deficient the clock genes Cry1 Cry2 unexpectedly display an autoimmune phenotype high serum IgG concentrations, presence antinuclear antibodies, precipitation IgG, IgM, complement 3 in glomeruli. Our results suggest B cell development,...
An unhealthy diet has been linked to increased incidence of chronic diseases. To investigate the relationship between and intestinal inflammation, mice in two experimental groups were fed on a high-fat or high-fructose diet, respectively. The result showed that defecation volume was significantly reduced compared with control group, levels pro-inflammatory cytokines (interleukin (IL)-1β IL-6) IgG serum significantly. In addition, inflammatory cell infiltration observed tissue, indicating can...
The traditional view that immunoglobulin is produced only by differentiated B lymphocytes has been challenged as genes have found to be expressed in nonhematopoietic human cancer cells. However, this phenomenon not widely accepted, and knowledge about newly discovered concept limited. In study, we investigated the IgG1 heavy chain (IGHG1) constant region gene IgG protein expression 6 cell lines, including epithelial cells, tissues from 66 hyperplasias, adenomas, carcinomas. We also studied...
The gut microbiota represents an important reservoir of antibiotic-resistant bacteria (ARB), which poses a significant threat to public health. However, little is known about the emergence ARB in after combined exposure antibiotics and non-antibiotic pharmaceutics. Here, Escherichia coli, common opportunistic pathogen microbiota, was exposed antidepressant duloxetine (2.5 µg/L–25 mg/L) and/or chloramphenicol (6 µg/L–4 mg/L). resistant strains were isolated determine minimum inhibition...
Increasing evidence indicates that various cancer cell types are capable of producing IgG. The exact function cancer-derived IgG has, however, not been elucidated. Here we demonstrated the expression genes with V(D)J recombination in 80 cases colorectal cancers, 4 colon lines and a tumor bearing immune deficient mouse model. was associated differentiation, pTNM stage, lymph node involvement inflammatory infiltration positively correlated expressions Cyclin D1, NF-κB PCNA. Furthermore,...
Abstract The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) presents a global public health threat. Most research on therapeutics against SARS-CoV-2 focused the receptor binding domain (RBD) Spike (S) protein, whereas vulnerable epitopes and functional mechanism non-RBD regions are poorly understood. Here we isolated characterized monoclonal antibodies (mAbs) derived from convalescent COVID-19 patients. An mAb targeting N-terminal...
Abstract The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by infection- and vaccination-induced antibodies, highlighting the demands for research on continuing discovery of broadly neutralizing antibodies (bnAbs). Here, we developed a panel bnAbs against other variants concern (VOCs) elicited vaccination adenovirus-vectored COVID-19 vaccine (Ad5-nCoV). We also investigated human longitudinal antibody responses following demonstrated how evolved over time. A...
The traditional view that immunoglobulin (Ig) is produced only by B lymphocytes has been challenged, because it demonstrated Ig genes and proteins are expressed in epithelial cancer cells. However, whether expression nonlymphoid cells limited to unclear. Because sarcomas differ distinctly from carcinomas their biologic clinical features, the authors investigated question of IgG soft tissue lesions.Immunohistochemistry, situ hybridization, polymerase chain reaction (PCR) were used demonstrate...
Abstract The pandemic of COVID-19 caused by SARS-CoV-2 continues to spread around the world. Mutant strains are constantly emerging. At present, Omicron variants have become mainstream. In this work, we carried out a systematic and comprehensive analysis reported spike protein antibodies, counting epitopes genotypes these antibodies. We further comprehensively analyzed impact mutations on antibody classified antibodies according their binding patterns. found that H-RBD class were...
Abstract The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between attachment (G) fusion (F) glycoproteins required virus entry remains unclear. Here, we isolate a panel of Macaca-derived G-specific antibodies that cross-neutralize HNVs via multiple mechanisms. most potent antibody, 1E5, confers adequate protection against challenge in female hamsters. Crystallography demonstrates 1E5 has...
Abstract BACKGROUND In spite of recent advances in treatment strategies, prostate cancer (PCa) remains the second leading cause death men with its genetic and biologic behaviors still poorly understood. Recently, accumulating evidence indicates that cells, as well some normal cells can secret IgG. This study was designed to evaluate IgG gene expression possible significance PCa tissue samples cell lines. METHODS assessed by immunohistochemistry, situ hybridization, immunofluorescence,...
We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like (PirB) as receptors for several angiopoietin-like proteins (Angptls). also demonstrated that PirB is important development of acute myeloid leukemia (AML), but exactly how an inhibitory such can support cancer intriguing. Here, we showed activation Ca (2+)/calmodulin-dependent protein kinases (CAMKs) coupled with signaling in AML cells. High expression CAMKs associated a...