A5085405184- Cholangiocarcinoma and Gallbladder Cancer Studies
- Vascular Tumors and Angiosarcomas
- Virology and Viral Diseases
- Pancreatic and Hepatic Oncology Research
- Vector-Borne Animal Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- CNS Lymphoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Cerebral Venous Sinus Thrombosis
- vaccines and immunoinformatics approaches
- Medical Imaging and Pathology Studies
- Plant Virus Research Studies
- Histiocytic Disorders and Treatments
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Respiratory viral infections research
- Gastrointestinal Tumor Research and Treatment
- Estrogen and related hormone effects
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Autoimmune Neurological Disorders and Treatments
- Endometriosis Research and Treatment
Fujian Medical University
2025
Fuzhou Maternity and Child Health Care Hospital
2025
Union Hospital
2025
Capital Medical University
2025
Fudan University
2021-2024
Zhongshan Hospital
2021-2024
Chinese Academy of Sciences
2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2021-2024
Wuhan Institute of Virology
2024
Abstract Nipah virus (NiV) is a World Health Organization priority pathogen and there are currently no approved drugs for clinical immunotherapy. Through the use of naïve human phage-displayed Fab library, two neutralizing antibodies (NiV41 NiV42) targeting NiV receptor binding protein (RBP) were identified. Following affinity maturation, derived from NiV41 display cross-reactivity against both Hendra (HeV), whereas antibody based on NiV42 only specific to NiV. Results immunogenetic analysis...
Abstract The Hendra and Nipah viruses (HNVs) are highly pathogenic pathogens without approved interventions for human use. In addition, the interaction pattern between attachment (G) fusion (F) glycoproteins required virus entry remains unclear. Here, we isolate a panel of Macaca-derived G-specific antibodies that cross-neutralize HNVs via multiple mechanisms. most potent antibody, 1E5, confers adequate protection against challenge in female hamsters. Crystallography demonstrates 1E5 has...
Objective: The clinicopathological features of pulmonary epithelioid hemangioendothelioma (PEHE) were analyzed to provide guidance for clinical practice. Methods: manifestations, imaging examination, pathological morphology and molecular characteristics, treatment prognosis patients with retrospectively collected. All cases admitted Fujian Medical University Union Hospital from January 2012 May 2023. Results: Of 7 PEHE cases, 2 underwent tumor biopsy 5 resection. There 4 males 3 females, a...
Adenomyosis (AM) is characterized as a chronic and progressive disorder with limited therapeutic strategies available. Myometrial fibrosis prominent pathological feature of AM, yet the underlying molecular mechanisms remain elusive. The present study conducted comparative analysis using proteomics metabolomics to investigate myometrial its mechanisms. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized analyze adenomyotic normal tissues from ten AM patients who underwent...
With the development of testing technology, diagnosis nontuberculous mycobacterium (NTM) lung disease has gradually increased in recent years. Because clinical characteristics NTM are not typical, and its imaging manifestations diverse nonspecific, missed misdiagnosis common. Etiological investigation is necessary for diagnosis. Conventional etiological investigations very limited NTM. We reported a case presenting with mass atelectasis mediastinal hilar lymph node enlargement that resembled...
To explore the magnetic resonance imaging (MRI) features and classification of intraductal papillary neoplasm bile duct (IPNB).
To explore the MRI characteristics of hepatic epithelioid hemangioendothelioma (HEHE) classification according to morphology and size.
肝脏钙化性巢状间质-上皮肿瘤（calcifying nested stromal-epithelial tumor，CNSET）是一种非肝细胞、非胆管细胞原发的肝脏低度恶性潜能肿瘤，非常罕见。目前国外报道病例52例，国内报道仅2例。本文报道1例肝脏CNSET，并结合相关文献复习，以提高临床和病理医师对该肿瘤的认识水平，从而为患者的及时治疗提供机会。.
Objective: To investigate the MRI manifestations of lymphoepithelioma-like intrahep cholangiocarcinoma (LEL-ICC). Methods: MR images 26 cases with LEL-ICC confirmed pathologically at Zhongshan Hospital Affiliated Fudan University between March 2011 and 2021 were retrospectively analyzed. The number, location, size, morphology, edges lesions, non-scan signal intensity, cystic necrosis, enhancement mode, peak, capsule, vascular invasion, lymph node metastasis, other included for analysis....
目的： 以HER2荧光原位杂交（FISH）检测作为参照，使用免疫组织化学（IHC）法比较2种抗体对胆囊腺癌HER2蛋白检测效能。 方法： 建立一组包含108例胆囊浸润性腺癌的高产组织芯片，用2种抗HER2抗体（克隆号4B5和A0485）在其相对应平台检测HER2蛋白表达，FISH方法检测HER2基因扩增。用ROC曲线计算IHC灵敏度、特异度及准确度，Kappa系数分析一致性，McNemar检验比较各组间检出率差异。 结果： HER2基因扩增病例为23例（21.3%）。4B5抗体的表达结果（3+、2+、0/1+）为12、13、83例。IHC 3+检出HER2基因扩增的灵敏度和特异度分别为52.2%和100%。A0485抗体的表达结果（3+、2+、0/1+）为22、45、41例。IHC 3+检出HER2基因扩增的灵敏度和特异度分别为65.2%和68.2%。两组结果差异有统计学意义（P<0.01）。以IHC 2/3+作为阳性，4B5抗体检出HER2扩增的灵敏度和特异度分别为78.3%和72.0%，A0485为100%和34.3%，结果差异有统计学意义（P<0.01）。4B5抗体IHC...