A5100419274- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Fire effects on ecosystems
- Viral Infections and Vectors
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Wound Healing and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Mesenchymal stem cell research
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced X-ray and CT Imaging
- AI in cancer detection
- Periodontal Regeneration and Treatments
- Ureteral procedures and complications
- Eosinophilic Disorders and Syndromes
- RNA regulation and disease
- Molecular Communication and Nanonetworks
- Amoebic Infections and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Inhalation and Respiratory Drug Delivery
- Parasites and Host Interactions
- Long-Term Effects of COVID-19
- Endoplasmic Reticulum Stress and Disease
Renji Hospital
2025
Shanghai Jiao Tong University
2025
Academy of Military Medical Sciences
2018-2024
Anhui Medical University
2024
Fudan University Shanghai Cancer Center
2024
Ningbo Center for Disease Control and Prevention
2021-2024
Second Military Medical University
2003-2023
Changhai Hospital
2023
Public Health Clinical Center of Chengdu
2023
Henan Provincial People's Hospital
2021-2022
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on receptor binding domain (RBD) Spike (S) protein but also across full protein. We isolated and characterized monoclonal antibodies (mAbs) from 10 convalescent COVID-19 patients. Three mAbs showed neutralizing activities authentic SARS-CoV-2. One mAb, named 4A8, exhibits high neutralization potency both pseudotyped SARS-CoV-2 does bind RBD....
SARS-CoV-2 has caused millions of deaths, and, since Aug 11, 2020, 20 intramuscular COVID-19 vaccines have been approved for use. We aimed to evaluate the safety and immunogenicity an aerosolised adenovirus type-5 vector-based vaccine (Ad5-nCoV) in adults without from China.This was a randomised, single-centre, open-label, phase 1 trial done Zhongnan Hospital (Wuhan, China), Ad5-nCoV by aerosol inhalation (≥18 years) seronegative SARS-CoV-2. Breastfeeding or pregnant women people with major...
Objective To compare the effectiveness and safety of tofacitinib (TOF) versus calcineurin inhibitor (CNI) as initial immunosuppressive regimen for anti-melanoma differentiation-associated gene 5-positive dermatomyositis with interstitial lung disease (MDA5+DM-ILD). Methods Adult Chinese patients newly-diagnosed MDA5+DM-ILD (ILD course<3 months) from five tertiary referral centres between April 2014 January 2023 were included this retrospective cohort study. The primary endpoint was...
To assess the efficacy and safety of transarterial Chemoembolization (TACE) combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma (HCC).The data patients HCC administered a combination therapy TACE were retrospectively assessed. Patients received orally once daily 2 weeks before TACE, followed by administration at 200 mg intravenously on day 1 21-day therapeutic cycle after TACE. The primary endpoints objective response rate (ORR) duration (DOR) modified RECIST...
Fibroblasts are the major effector cells of skin wound healing. Adipose‑derived stem can differentiate into fibroblasts under certain conditions. In present study, it was hypothesized that adipose‑derived (ADSCs) could be induced by adipose extracellular matrix (ECM) to in order promote First, flow cytometry used detect ratio and relative expression fibroblast markers cytokeratin 19 (CK19) vimentin ADSCs. Then, effect ECM during differentiation ADSCs investigated detecting total amount...
Abstract The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by infection- and vaccination-induced antibodies, highlighting the demands for research on continuing discovery of broadly neutralizing antibodies (bnAbs). Here, we developed a panel bnAbs against other variants concern (VOCs) elicited vaccination adenovirus-vectored COVID-19 vaccine (Ad5-nCoV). We also investigated human longitudinal antibody responses following demonstrated how evolved over time. A...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) continue to wreak havoc across the globe. Higher transmissibility and immunologic resistance VOCs bring unprecedented challenges epidemic extinguishment. Here we describe a monoclonal antibody, 2G1, that neutralizes all current has surprising tolerance mutations adjacent or within its interaction epitope. Cryo-electron microscopy structure showed 2G1 bound tip receptor binding domain (RBD) spike protein...
Background Tuberculosis (TB), particularly drug-resistant TB (DR-TB), remains a significant public health concern in Ningbo, China. Understanding its molecular epidemiology and spatial distribution is paramount for effective control. Methods From December 24, 2020, to March 12, 2023, we collected clinical Mycobacterium tuberculosis (MTB) strains with whole-genome sequencing performed on 130 MTB strains. We analyzed DR-related gene mutations, conducted phylogenetic phylodynamic analyses,...
As a multicellular parasitic nematode, Trichinella spiralis regulates host immune responses by producing variety of immunomodulatory molecules to escape from attack, but the mechanisms underlying evasion are not well understood. Here, we identified that T. calreticulin (Ts-CRT), Ca2+ binding protein, facilitated interacting with first component human classical complement pathway, C1q. In present study, Ts-CRT was found be expressed on surface different developmental stages as in secreted...
To gain more insight into the phylogeny of Dabieshan virus (DBSV), carried by Niviventer confucianus and other Murinae-associated hantaviruses, genome sequences novel variants DBSV were recovered from rats trapped in mountainous areas Wenzhou, China. Genetic analyses show that all known genetic DBSV, including ones identified this study, are distinct hantaviruses. geographic clustering high intraspecies diversity. The data suggest is a species genus Hantavirus. Interestingly, shows highest...
Novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) is pandemic. However, data concerning the epidemiological features, viral shedding, and antibody dynamics between asymptomatic SARS-CoV-2 carriers COVID-19 patients remain controversial. We enrolled 193 infected subjects in Ningbo Zhoushan, Zhejiang, China, from January 21 to March 6, 2020. All were followed up monitor of serum immunoglobulin M (IgM) IgG against using colloidal gold-labeled...
The efficacy of ethiodized poppyseed oil in hysterosalpingography (HSG) image quality and fertility enhancement has been revealed, but whether this HSG modality similar effects the Chinese population is still unclear.Between July 18, 2017, December 29, 2019, multicentric, randomized, two-arm, clinical trial was performed involving 15 medical centers. Infertile women meeting indications were randomly assigned to an group a water group. coprimary outcome included during fertility-enhancing...
Abstract Background To evaluate the relationship between coronavirus disease 2019 (COVID-19) infection at different time points during pregnancy and perinatal outcomes. Methods This retrospective study included 611 women who hospitalized for delivery December 7 April 30, 2023. Based on weeks infected with COVID-19, participants were divided into four groups: Group 1 (14–27 +6 gestation), 2 (28–36 3 (37–39 4 (≥ 40 gestation). Data including maternal demographic characteristics, clinical...
Seroprevalence of Entamoeba histolytica infection in HIV-infected individuals from Shanghai city, Anhui province, and Henan China, was examined by enzyme-linked immunosorbent assay using crude antigen a recombinant surface antigen, C-Igl, the parasite. In 215 individuals, positive rates for these antigens were 12.1% 7.9%, respectively; significantly higher than 3.1% 0.5%, respectively, 191 patients with gastrointestinal symptoms who not infected HIV. There no significant difference...
The Rift Valley fever virus (RVFV) is an arthropod-borne that can not only cause severe disease in domestic animals but also humans. However, the licensed vaccines or available therapeutics for humans do exist. Here, we report two Gn-specific neutralizing antibodies (NAbs), isolated from a rhesus monkey immunized with recombinant human adenoviruses type 4 expressing Gn and Gc protein (rHAdV4-GnGcopt). NAbs were both able to protect host cells RVFV infection. interactions between then...
Coronavirus disease 2019 (COVID-19) caused by the Omicron variant occurred in Shanghai, China, but its clinical characteristics and virology have not been comprehensively described.This retrospective cohort study included adult inpatients (≥18 years) diagnosed with COVID-19 at Changhai Hospital. Laboratory data were obtained from electronic medical records to investigate of variations patients' laboratory indexes examined.The symptoms relatively mild. Upper respiratory tract specimens...
Organism can lead to excessive nutrient consumption in the infected state and increase nutritional risk, which is detrimental control of infection further aggravate disease.To investigate impact risk NRS2002 score on disease progression prognosis patients with COVID-19.This was a retrospective cohort study including 1,228 COVID-19 patients, who were divided into with-nutritional group (patients ≥ 3) without-nutritional < according at admission. The differences clinical outcome data between...
Gliomatosis cerebri (GC) is a rare glial neoplasm, characterized by extensive diffuse brain infiltration and relative preservation of the underlying architecture. In present case report, patient with type 2 GC, which mimicked clinicoradiological course acute viral encephalitis, presented. A 56-year-old male presented fever, dizziness, headache numbness in right extremities three days prior to admission hospital. The cerebrospinal fluid (CSF) showed mild pleocytosis. Brain magnetic resonance...
Abstract Numerous mutations in the spike protein of SARS-CoV-2 B.1.1.529 Omicron variant pose a crisis for antibody-based immunotherapies. The efficacy emergency use authorized (EUA) antibodies that developed early pandemic seems to be flounder. We tested neutralization an B cell antibody repertoire as well several EUA pseudovirus and authentic virus systems. More than half showed good activity against WA1/2020 previously had completely lost neutralizing Omicron, while 8G3 displayed...
Abstract To inform seroepidemiological studies, we characterized the IgG‐ responses in COVID‐19 patients against two major SARS‐CoV‐2 viral proteins, spike (S) and nucleocapsid (N). We tested 70 sera collected up to 85 days post‐symptom onset 230 non‐COVID‐19 sera, including 27 SARS from 2003. Although average S N‐IgG titers were comparable, N‐responses more variable among individuals. S‐ N‐assay specificity with comparable at 97.5% 97.0%, respectively. Therefore, will make a better target...