A5044744366- Psoriasis: Treatment and Pathogenesis
- Traumatic Brain Injury and Neurovascular Disturbances
- Atherosclerosis and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Traumatic Brain Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Lipoproteins and Cardiovascular Health
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- S100 Proteins and Annexins
- Liver Disease and Transplantation
- Pancreatic and Hepatic Oncology Research
- Diverticular Disease and Complications
- Phosphodiesterase function and regulation
- Vitamin C and Antioxidants Research
- Cancer Research and Treatment
- Anesthesia and Neurotoxicity Research
- Nerve injury and regeneration
- Metastasis and carcinoma case studies
- Signaling Pathways in Disease
- Congenital Diaphragmatic Hernia Studies
- Automotive and Human Injury Biomechanics
- Viral-associated cancers and disorders
- Health, psychology, and well-being
Thomas Jefferson University Hospital
2023-2024
Columbia University
2018-2023
Stratford University
2023
University of Maryland, Baltimore
2021
Icahn School of Medicine at Mount Sinai
2020
National Heart Lung and Blood Institute
2018-2019
National Institutes of Health
2018-2019
National Institute on Aging
2018
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Chronic hepatitis B virus (HBV) infection is the largest global cause of hepatocellular carcinoma (HCC). Current HBV treatment options include pegylated interferon-alpha and nucleos(t)ide analogues (NAs), which have been shown to be effective in reducing DNA levels become undetectable. However, literature has that some patients persistent risk developing HCC. The mechanism this occurs not fully elucidated. it discovered HBV’s covalently closed circular (cccDNA) integrates into critical HCC...
Inflammation is critical to atherogenesis. Psoriasis a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides compelling model understand potential pathways linking these diseases. A murine capturing the vascular metabolic diseases psoriasis would accelerate our understanding provide platform test emerging therapies. We aimed characterize new of inflammation (Rac1V12) from cardiovascular standpoint identify novel atherosclerotic signaling modulated...
Background: Spontaneous firing of sinoatrial node cells (SANCs) is regulated by cAMP-mediated, PKA (protein kinase A)-dependent (cAMP/PKA) local subsarcolemmal Ca 2+ releases (LCRs) from RyRs (ryanodine receptors). LCRs occur during diastolic depolarization and activate an inward Na + /Ca exchange current that accelerates rate prompting the next action potential. PDEs (phosphodiesterases) regulate cAMP-mediated signaling; PDE3/PDE4 represent major PDE activities in SANC, but how they...
Event Abstract Back to Bridging the gap between in vivo and vitro research: Reproducing mechanical electrical environment of cells Oliver Graudejus1, 2*, Ruben D. Ponce Wong1, Nevin Varghese3, Sigurd Wagner4 Barclay Morrison3 1 BMSEED LLC, United States 2 Arizona State University, School Molecular Sciences, 3 Columbia Biomedical Engineering, 4 Princeton Electrical In research has many advantages over research, such as (1) tight control chemical physical environment, (2) reduced cost (3)...
Psoriasis, a chronic inflammatory skin disease associated with accelerated noncalcified coronary burden (NCB) by computed tomography angiography (CCTA), accelerates lipoprotein oxidation in the form of oxidized modified lipoproteins. A transmembrane scavenger receptor for these lipoproteins is lectinlike low-density receptor-1 (LOX-1), which has been reported to be artery disease. It unknown whether this psoriasis.To assess association between soluble LOX-1 (sLOX-1) and NCB psoriasis over...
Traumatic brain injury (TBI) is a major cause of hospitalization and death. To mitigate these human costs, the search for effective drugs to treat TBI continues. In current study, we evaluated efficacy novel neurosteroid, NTS-105, reduce post-traumatic pathobiology in an vitro model moderate that utilizes organotypic hippocampal slice culture. NTS-105 inhibited activation androgen receptor mineralocorticoid receptor, partially activated progesterone B was not active at glucocorticoid...
Blast-induced traumatic brain injury (bTBI) has been a health concern in both military and civilian populations due to recent geopolitical conflicts. Military service members are frequently exposed repeated bTBI throughout their training deployment. Our group previously reported compounding functional deficits as result of increased number blast exposures. In this study, we further characterized the decrease long-term potentiation (LTP) by varying severity inter-blast interval between two...
Introduction: Immunotherapy, such as pembrolizumab, is an effective treatment for various types of cancers, including lung, cervical, and ovarian cancers. It has been associated with acute liver injury, pancreatitis, colitis, Guillain- Barré Syndrome, hypothyroidism. There have several case reports pembrolizumab-induced pancreatitis. We present a unique pembrolizumab elevated lipase amylase in the absence Case Description/Methods: A 76-year-old female past medical history carcinosarcoma pT2a...
Introduction: Liver abscesses are purulent masses that develop from intra-abdominal infections disseminated the portal venous system. The majority of liver caused by bacteria and less commonly fungi or parasites. most common causing pyogenic Klebsiella pneumoniae, Escherichia coli (E. Coli), Streptococcus anginosus, anaerobes. incidence is increased in patients with type II diabetes mellitus underlying malignancy. We present a case secondary to E. setting dental caries. Case...
Chronic hepatitis B virus (HBV) infection is the largest global cause of hepatocellular carcinoma (HCC). Current HBV treatment options include pegylated interferon-alpha and nucleos(t)ide analogues (NAs), which have been shown to be effective in reducing DNA levels become undetectable. However, literature has that some patients persistent risk developing HCC. The mechanism this occurs not fully elucidated, however it discovered covalently closed circular (cccDNA) integrates into critical HCC...
Acute liver injury may be very difficult to treat, especially when the etiology is unknown. We describe a case of patient who presented with signs and symptoms acute went through an extensive work-up that did not reveal definitive cause. The lack diagnosis can distressing for patient, so it important regularly communicate current plan potential future necessary steps (such as transplant surgery) facilitate smooth, informed decision-making throughout whole process.