A5081156577- Psoriasis: Treatment and Pathogenesis
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Cytokine Signaling Pathways and Interactions
- Cardiovascular Disease and Adiposity
- Vitamin D Research Studies
- Cardiomyopathy and Myosin Studies
- Lipoproteins and Cardiovascular Health
- Melanoma and MAPK Pathways
- Healthcare Operations and Scheduling Optimization
- Helminth infection and control
- Coccidia and coccidiosis research
- Diverse Scientific Research Studies
- S100 Proteins and Annexins
- Genetic Syndromes and Imprinting
- Vitamin C and Antioxidants Research
- Hospital Admissions and Outcomes
- Heat shock proteins research
- Research on Leishmaniasis Studies
National Heart Lung and Blood Institute
2019-2023
National Institutes of Health
2019-2023
Cleveland Clinic
2020-2023
University of Kansas
2023
Emory University
2023
CorVita Science Foundation
2023
The Wistar Institute
2016-2017
Targeting multiple components of the MAPK pathway can prolong survival patients with BRAFV600E melanoma. This approach is not curative, as some BRAF-mutated melanoma cells are intrinsically resistant to inhibitors (MAPKi). At systemic level, our knowledge how signaling pathways underlie drug resistance needs be further expanded. Here, we have shown that a low basal level mitochondrial biogenesis depend on this process survive MAPKi. Intrinsically exploited an integrated stress response,...
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably luminal plaque, but it unclear whether these associations are attributable direct anti-inflammatory effects on the arteries.To investigate association of biologic inflammation in patients using perivascular fat attenuation index (FAI), novel imaging biomarker that assesses by mapping spatial changes...
Abstract In melanoma, therapies with inhibitors to oncogenic BRAF V600E are highly effective but responses often short-lived due the emergence of drug-resistant tumor subpopulations. We describe here a mechanism acquired drug resistance through microenvironment, which is mediated by human tumor-associated B cells. Human melanoma cells constitutively produce growth factor FGF-2, activates tumor-infiltrating IGF-1. B-cell-derived IGF-1 critical for melanomas and MEK heterogeneous...
Background: Lipid-rich necrotic core (LRNC), a high-risk coronary plaque feature assessed by computed tomography angiography, is associated with increased risk of future cardiovascular events in patients subclinical, nonobstructive artery disease. Psoriasis chronic inflammatory condition that prevalence and events. This study characterized LRNC psoriasis how modulates response to biologic therapy. Methods: Consecutive naïve (n=209) underwent angiography at baseline 1-year assess changes...
Psoriasis, a chronic inflammatory skin disease associated with accelerated noncalcified coronary burden (NCB) by computed tomography angiography (CCTA), accelerates lipoprotein oxidation in the form of oxidized modified lipoproteins. A transmembrane scavenger receptor for these lipoproteins is lectinlike low-density receptor-1 (LOX-1), which has been reported to be artery disease. It unknown whether this psoriasis.To assess association between soluble LOX-1 (sLOX-1) and NCB psoriasis over...
The severity classification of functional mitral regurgitation (FMR) remains controversial despite adverse prognosis and rapidly evolving interventions. Furthermore, it is unclear if quantitative assessment with cardiac magnetic resonance can provide incremental risk stratification for patients ischemic cardiomyopathy (ICM) or non-ICM (NICM) in terms FMR late gadolinium enhancement (LGE). We evaluated the impact parameters on event-free survival separately ICM NICM, to assess prognostic...
A 23-year-old, previously healthy woman presented with a first-onset generalized tonic-clonic seizure.Neurological examination was unremarkable.Computed tomography of the brain showed extensive symmetric calcifications in corticomedullary junctions, basal ganglia, thalami, and cerebellar hemispheres (Fig. 1).Serum laboratory studies revealed levels calcium 5.7 mg/dL (8.6-10.2mg/ dL), phosphorus 4.4 (3.5-4.5 mg/dL), parathyroid hormone 151 pg/mL (10-65 pg/mL) consistent...
The August highlights from the Circulation family of journals cover a variety interesting topics.The experience with novel extravascular ICD lead is reported in Circulation: Arrhythmia and Electrophysiology.The incidence cardiogenic shock among patients end-stage renal disease described Heart Failure.The patient perspective on generator exchanges are Cardiovascular Quality Outcomes.The prognostic utility cardiac MRI-based scar quantification functional mitral regurgitation assessment for...
Background: Psoriasis, a chronic inflammatory disease, is associated with accelerated vascular inflammation (VI) by FDG PET/CT and increased cardiometabolic dysfunction, including adipose tissue dysregulation. Both visceral subcutaneous volume are sub-clinical aortic VI as well future cardiovascular events, however, the relationship of (assessed uptake) has never been characterized in psoriasis. Methods: 104 consecutive biologic naïve psoriasis patients underwent scans to measure uptake,...
Introduction: Psoriasis (PSO) is a chronic inflammatory condition associated with accelerated atherosclerosis and increased risk of myocardial infarction in part mediated through high visceral adipose tissue (VAT) volume. VAT has been shown to be coronary burden; however, the relationship prevalent plaque PSO not explored. Hypothesis: We hypothesized that would associate beyond traditional factors. Methods: A total 164 consecutive patients underwent computed tomography angiography (CCTA) as...
Background: Functional mitral regurgitation (MR) is associated with poor outcomes and the prognostic role of cardiac magnetic resonance imaging (CMR) quantification secondary MR has rarely been studied. We evaluated associations between CMR-derived MR-fraction adverse in non-ischemic cardiomyopathy (NICM) patients. Methods: retrospectively studied 840 consecutive NICM patients undergoing CMR during 2001/4/1-2019/3/31. Multivariable Cox proportional hazards regression was performed for two...