A5054063371- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Adolescent and Pediatric Healthcare
- Spondyloarthritis Studies and Treatments
- Inflammasome and immune disorders
- Immunodeficiency and Autoimmune Disorders
- Kawasaki Disease and Coronary Complications
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Temporomandibular Joint Disorders
- Pharmaceutical studies and practices
- Musculoskeletal Disorders and Rehabilitation
- Acute Lymphoblastic Leukemia research
- Otitis Media and Relapsing Polychondritis
- Inflammatory Myopathies and Dermatomyositis
- Hip disorders and treatments
- Pediatric health and respiratory diseases
- Infectious Diseases and Tuberculosis
- Lymphadenopathy Diagnosis and Analysis
- Neurogenetic and Muscular Disorders Research
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone fractures and treatments
- Orthopedic Infections and Treatments
HNO Bad Bramstedt
2015-2024
Emory University
2023
American College of Rheumatology
2023
Durham VA Medical Center
2023
University of North Carolina at Chapel Hill
2023
Istituto Giannina Gaslini
2017-2020
Cincinnati Children's Hospital Medical Center
2019
Golisano Children's Hospital
2019
University of Cincinnati
2019
Research Network (United States)
2019
Musculoskeletal ultrasonography (US) has the potential to be an important tool in assessment of disease activity childhood arthritides. To assess pathology, clear definitions for synovitis need developed first. The aim this study was develop and validate these through international consensus process.The decision on which US techniques use components included definitions, as well final wording, were by 31 experts a process. A Likert scale 1-5 (where 1 = complete disagreement 5 agreement)...
Musculoskeletal ultrasonography (US) has potential in the assessment of disease activity and structural damage childhood arthritides. In order to assess pathology, US characteristics joints healthy children need be defined first. The aim this study was develop definitions for various components normal pediatric joint.The were developed by an expert group applicability assessed on a collection standardized scans knee ankle scoring Likert scale. then modified reassessed before sending approval...
Human multipotent mesenchymal stromal cells ( MSC s) are clinically applied to treat autoimmune diseases and graft‐versus‐host disease due their immunomodulatory properties. Several molecules have been identified mediate these effects, including constitutively expressed galectin‐1. However, there indications in the literature that s exert enhanced immunosuppressive functions after interaction with an inflammatory environment. Therefore, we analyzed how stimuli influence expression of...
This report aims to determine the safety, pharmacokinetics (PK) and efficacy of subcutaneous golimumab in active polyarticular-course juvenile idiopathic arthritis (polyJIA).In this three-part randomised double-blinded placebo-controlled withdrawal trial, all patients received open-label (30 mg/m2 body surface area; maximum: 50 mg/dose) every 4 weeks together with weekly methotrexate during Part 1 (weeks 0-16). Patients at least 30% improvement per American College Rheumatology Criteria for...
Natural CD4+CD25+FoxP3+ Treg cells play a crucial role in maintaining immune homeostasis and controlling autoimmunity. In patients with juvenile idiopathic arthritis (JIA), inflammation occurs despite the increased total numbers of synovial fluid (SF) compared to peripheral blood (PB). This study was undertaken investigate phenotype CD4+ T PB SF from JIA patients, function cells, sensitivity CD4+CD25- effector immunoregulatory properties suppression cytokine secretion by cells.The phenotypes...
Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease and a leading cause of childhood disability. The objective this study was to characterize PK, safety, taste acceptability tofacitinib in patients with JIA. This Phase 1, open-label, multiple-dose (twice daily [BID] for 5 days) active (≥ joints) polyarticular course JIA conducted from March 2013–December 2015. Patients were allocated one three age-based cohorts: Cohort 12 < 18 years; 2, 6 3, 2 years....
Temporomandibular joint (TMJ) arthritis, commonly considered oligoarthritic/asymptomatic, occurs frequently in children with juvenile idiopathic arthritis (JIA), and gadolinium-enhanced magnetic resonance imaging (Gd-MRI) has proved to be a sensitive diagnostic tool this context. We compared the reliability of clinical examinations Gd-MRI results diagnosing condition. Patients JIA (134 consecutive) underwent routine examinations. The items examined were clicking, tenderness (TMJ/adjacent...
Objective To determine the intra‐ and interobserver reliability of ultrasound ( US )‐detected age‐related joint vascularization ossification grading in healthy children. Methods Following standardized image acquisition machine setting protocols, 10 international experts examined 4 joints (wrist, second metacarpophalangeal joint, knee, ankle) 12 children (divided into age groups: 2–4, 5–8, 9–12, 13–16 years). Gray‐scale was used to detect grade, power Doppler PDUS ) physiologic...
Our objective was to describe the spectrum of MRI features in patients with deep and generalized morphea.Imaging morphea are not specific usually overlap those other disorders involving skin, fascia, musculature, such as some types fasciitis, myositis, so forth. Nevertheless, imaging reflect pathomorphologic changes this rare disorder enable a complete assessment disease extent, including depth infiltration activity.
The temporomandibular joints (TMJs) are frequently affected in children with juvenile idiopathic arthritis (JIA). Early detection is challenging, as major variation present scoring TMJ pathology on magnetic resonance imaging (MRI). Consensus-driven development and validation of an MRI system for TMJs has important clinical utility timely improvement diagnosis serving outcome measure. We report a multi-institutional collaboration toward developing JIA.Seven readers independently assessed...
Objective To investigate the pharmacokinetics, effectiveness, and safety of subcutaneous ( SC ) abatacept treatment over 24 months in patients with polyarticular‐course juvenile idiopathic arthritis JIA ). Methods In this phase III , open‐label, international, multicenter, single‐arm study, polyarticular (cohort 1, ages 6–17 years cohort 2, 2–5 years) whom ≥1 disease‐modifying antirheumatic drug was unsuccessful received weight‐tiered weekly: 10 to <25 kg (50 mg), 25 <50 (87.5 ≥50 (125...
Recently preliminary ultrasonography (US) definitions, in B mode, for normal components of pediatric joints have been developed by the OMERACT US group. The aim current study was to include Doppler findings evaluation and definition joint features that can be visualized healthy children at different age groups. A multistep approach used. Firstly, new additional definitions were proposed during an expert meeting. In second step, these along with B-mode-US tested feasibility exercise last a...
Objective. The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCT) and longitudinal observational studies (LOS) was developed without the input of patients/parents. At Outcome Measures Rheumatology (OMERACT) 2016, a special interest group voted to reconsider core set, incorporating broader input. We describe subsequent work culminating an OMERACT 2018 plenary consensus voting. Methods. Candidate domains were identified through literature review,...
Abstract Objective The aim of this study was to report the interim 5-year safety and effectiveness abatacept in patients with JIA PRINTO/PRCSG registry. Methods Abatacept Registry (NCT01357668) is an ongoing observational children receiving abatacept; enrolment started January 2013. Clinical sites enrolled starting or currently abatacept. Eligible were assessed for (primary end point) over 10 years. Effectiveness measured by clinical 10-joint Juvenile Arthritis Disease Activity Score...
The purpose of our study was to test the hypothesis that real-time MRI-guided, selective injection procedures temporomandibular joints are feasible, accurate, and safe when performed on a clinical open-bore 1.5-T MR system.A retrospective analysis 67 (55% [37/67] were therapeutic injections, 27% [18/67] diagnostic 18% [12/67] arthrocentesis procedures), in 31 patients (58% [18/31] female, 42% [13/31] male; mean age, 14 years; age range, 3-34 years), made. Seven 38 (18%) subjects had two...
Muckle-Wells syndrome (MWS) is an inherited autoinflammatory disease characterized by fever, rash, arthralgia, conjunctivitis, sensorineural deafness and potentially life-threatening amyloidosis. The NLRP3/CIAS1 E311K mutation caused a heterogeneous phenotype of MWS in large family. This study analyzes the clinical spectrum, patterns inflammatory parameters reports on response to treatment.A total 42 patients family members were screened for presence NLRP3 mutation. Clinical symptoms...
To report on referral patterns of primary physicians for children subsequently diagnosed with juvenile idiopathic arthritis (JIA) and to identify predictors delayed a pediatric rheumatology center.A retrospective cohort study consecutive patients JIA referred center over 15-year period was performed. Variables included age, sex, subtype, the physician's subspecialty, distance center. Outcome parameters were time first presentation physician, visit, total referral. Putative evaluated by...
To report on efficacy, tolerability and safety of rituximab in children with refractory autoimmune diseases.Five patients (juvenile dermatomyositis, Wegener's granulomatosis, systemic lupus erythematosus, myasthenia gravis multiple sclerosis erythematosus) were treated followed for a median time 2.5 years. Two achieved remission (systemic granulomatosis). Three had disease course underwent autologous stem cell transplantation. Of those, two gravis), one died complications after...
To report on efficacy, tolerability and safety of rituximab in children with refractory autoimmune diseases. Five patients (juvenile dermatomyositis, Wegener's granulomatosis, systemic lupus erythematosus, myasthenia gravis multiple sclerosis erythematosus) were treated followed for a median time 2.5 years. Two achieved remission (systemic granulomatosis). Three had disease course underwent autologous stem cell transplantation. Of those, two gravis), one died complications after...
Background: Temporomandibular joints (TMJ) are frequently involved in children with juvenile idiopathic arthritis (JIA), and gadolinium-enhanced magnetic resonance imaging (MRI) is the only modality for an early diagnosis. However, very few data exist on appearance of contrast-enhanced MRI normal TMJ. Purpose: To define spectrum findings TMJ, to assess a possible overlap typical active synovitis JIA. Material Methods: 96 (192 TMJ), 51 boys 45 girls median age 7.8 years (range 3–13 years),...