A5048052584- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Inflammatory Bowel Disease
- Head and Neck Surgical Oncology
- Microscopic Colitis
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Trauma Management and Diagnosis
- Bacteriophages and microbial interactions
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Microbial Community Ecology and Physiology
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- Rheumatoid Arthritis Research and Therapies
- Biofuel production and bioconversion
- Ear and Head Tumors
- Lung Cancer Diagnosis and Treatment
- RNA and protein synthesis mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
Shanghai Municipal Center For Disease Control Prevention
2023-2025
Huazhong University of Science and Technology
2019-2025
Guangzhou University of Chinese Medicine
2024-2025
Kunming University of Science and Technology
2025
Pfizer (United States)
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
China Meteorological Administration
2022-2025
Exelixis (United States)
2025
Aviation Industry Corporation of China (China)
2025
Sun Yat-sen University
2014-2024
Concurrent chemoradiotherapy (CCRT) has been shown to improve outcomes for stage III-IV nasopharyngeal carcinoma (NPC) patients compared with radiotherapy (RT) alone, but the effectiveness of combined therapy II NPC is unknown.Patients Chinese 1992 were randomly assigned receive either RT alone (n = 114) or CCRT 116). The given concurrent cisplatin (30 mg/m(2) on day 1) weekly during RT. primary endpoint was overall survival (OS). Secondary endpoints progression-free (PFS), distant...
Abstract The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 subtypes, including tumour-infiltrating CD8 + T, regulatory (Treg), and dendritic (DCs), as well malignant different Epstein-Barr virus infection status. Trajectory exhausted...
Technological advances in rare DNA mutations detection have revolutionized the diagnosis and monitoring of tumors, but they are still limited by lack supersensitive high-coverage procedures for identifying low-abundance mutations. Here, we describe a single-tube, multiplex PCR-based system, A-Star, that involves hyperthermophilic Argonaute from Pyrococcus furiosus (PfAgo) highly efficient beneficial its compatibility with polymerase. This novel technique uses specific guide design strategy...
Temperature is a critical environmental factor affecting the growth and development of rice, especially under backdrop global climate change, where temperature fluctuations have become increasingly significant in influencing cycle rate rice. To comprehensively assess impact variations on different stages this study integrates data from multiple relevant studies published between 1980 2024. By selecting research focused influence changes rice cycle, meta-analysis conducted to systematically...
Bacterial cellulose (BC) is a highly crystalline and mechanically stable nanopolymer, which has excellent potential as material in many novel applications, especially if it can be produced large amounts from an inexpensive feedstock. Waste fiber sludge, residue with little or no value, originates pulp mills lignocellulosic biorefineries. A high low lignin content contributes to making the sludge suitable for bioconversion, even without thermochemical pretreatment step. In this study,...
Bacterial cellulose (BC) is a nanostructured material with unique properties and wide applicability. In order to decrease the production cost of bacterial cellulose, lignocellulose-based media have considerable potential as alternative cost-effective feedstocks. However, pretreatment enzymatic hydrolysis lignocellulose sugars also generate fermentation inhibitors. Detoxification lignocellulosic hydrolysates needed achieve efficient BC. this investigation, different methods for detoxification...
Induction or adjuvant chemotherapy with concurrent chemoradiotherapy (CCRT) are first-line treatment options for of locoregionally advanced nasopharyngeal carcinoma (LA-NPC). Adjuvant platinum regimens are, however, poorly tolerated, highlighting the unmet need an efficacious, tolerable regimen.
Angiogenesis, integral to the pathogenesis of rheumatoid arthritis (RA), contributes advancement synovial hyperplasia, pannus formation, and bone destruction. The precise effect Huayu Tongbi formula (HT), a proven traditional Chinese medicine for RA treatment, on angiogenesis remains uncertain. To investigate effects HT potential underlying molecular mechanisms. target spectrum pharmacological were screened using network pharmacology. In vitro, RA-FLS stimulated with CoCl2 simulate hypoxic...
Photoswitchable ultrahigh brightness red fluorescent polymer nanoparticles are synthesized and used in rewritable information encryption, anti-counterfeiting reversible fluorescence bioimaging.
A Gram-staining-positive, spore-forming, strictly anaerobic bacterium, designated strain LAM0A37 T , was isolated from enrichment samples collected a petroleum reservoir in Shengli oilfield. Cells of were rod-shaped and motile by peritrichous flagella. The optimal temperature pH for growth 40 °C 7.0–7.5, respectively. did not require NaCl but tolerated up to 3 % (w/v) NaCl. Strain able utilize glucose, fructose, maltose, xylose, sorbitol, cellobiose, melibiose melezitose as sole carbon...
To explore the potential targets underlying effect of sinomenine (SIN) on rheumatoid arthritis (RA) by utilizing a network pharmacology approach.SIN and its drug were identified using analysis followed experimental validation. First, Pharmmapper, UniProt GeneCards databases mined for information relevant to prediction SIN RA-related targets. Second, SIN-target gene SIN-RA target networks created in Cytoscape software collection candidate each component R software. Eventually, key enriched...
Nasopharyngeal carcinoma (NPC) is one of the most common malignancies in southern China and Southeast Asia, with highest metastasis rate among head neck cancers. The mechanisms underlying NPC progression remain poorly understood. Genome-wide expression profiling on 18 vs. noncancerous nasopharyngeal tissues together GeneGo pathway analysis verification cells revealed a potential role urokinase-type plasminogen activator receptor (uPAR) progression, which has not been investigated NPC. We...
Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, environmental factors. Genetic indicate that mutations chromatin-modifying enzymes are the frequent alterations NPC. Here, we used H3K27ac chromatin immune precipitation followed by deep sequencing (ChIP-seq) define epigenome primary biopsies, xenografts, an cell line, compared them immortalized normal...
The construction of artificial multienzyme nanodevices with desired spatial arrangements have shown great promise for improving the overall performance targeted enzyme cascades. However, it is a challenge to rationally design and construct multiple oligomeric assemblies that can be used as stable reusable catalysts. Herein, we report novel approach rapidly achieve ultrastable multimeric nanoclusters (MENCs) based on enzymes property oligomerization SpyTag/SpyCatcher system orthogonally...
Abstract N -Acyl homoserine lactones (AHLs) act as the key quorum sensing (QS) signal molecules in gram-negative bacteria, which coordinates gene expression and then activates various processes, including biofilm formation production of virulence factors some pathogens. Quorum quenching (QQ), is inactivation by means enzymatic degradation or modification, inhibits processes QS rather than killing pathogens a promising antipathogenic strategy to control bacterial In this study, an AHL...
Abstract Long non‐coding RNAs (lncRNAs) have been reported to participate in the pathogenesis of non–small cell lung cancer (NSCLC). However, how lncRNA deleted lymphocytic leukaemia 2 (DLEU2) contributes NSCLC remains undocumented. The clinical significance DLEU2 and miR‐30a‐5p expression was analysed by using fluorescence situ hybridization TCGA cohorts. Gain‐ loss‐of‐function experiments as well a tumour model were executed determine role NSCLC. DLEU2‐sponged verified luciferase reporter,...