A5100717698- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Rice Cultivation and Yield Improvement
- Microbial Community Ecology and Physiology
- Plant Disease Resistance and Genetics
- Molecular Biology Techniques and Applications
- Covalent Organic Framework Applications
- Autophagy in Disease and Therapy
- Coastal wetland ecosystem dynamics
- Radioactive element chemistry and processing
- Acute Ischemic Stroke Management
- Peatlands and Wetlands Ecology
- NF-κB Signaling Pathways
- Analytical Chemistry and Chromatography
- RNA Research and Splicing
- Parasite Biology and Host Interactions
- TGF-β signaling in diseases
- Agriculture, Soil, Plant Science
- Physical Activity and Health
- Pharmacological Effects and Assays
- Digestive system and related health
- Health and Well-being Studies
- Treatment of Major Depression
- Berberine and alkaloids research
- Metal-Organic Frameworks: Synthesis and Applications
East China Normal University
2025
Zhejiang University
2013-2025
University of Chinese Academy of Sciences
2020-2024
Hunan Entry-Exit Inspection and Quarantine Bureau
2024
Institute of Subtropical Agriculture
2021-2024
Chinese Academy of Sciences
2004-2024
Guangxi Normal University
2024
National University of Defense Technology
2024
Ministry of Education of the People's Republic of China
2024
Chongqing University
2023-2024
Extracting uranium from seawater with a chemically stable adsorbent is one of the most promising strategies for challenges originating sustainable nuclear energy industries. Covalent organic frameworks (COFs) featuring highly and regular porous network structures possess practical advantages compared to other adsorbents such as metal–organic frameworks. We are interested in designing rational monomers achieve novel COFs understanding structure–property relationships improve performance...
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. promotes the assembly removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how efficiently sequester Herein, we report undergoes reversible S-acylation in multiple human-, rat-, mouse-derived cell lines, catalyzed zinc-finger Asp-His-His-Cys S-acyltransferase 19 (ZDHHC19) deacylated acyl protein thioesterase 1 (APT1)....
Heparin-binding epidermal growth factor (HB-EGF) gene transcription is rapidly activated in NIH 3T3 cells transformed by oncogenic Ras and Raf mediates the autocrine activation of c-Jun N-terminal kinases (JNKs) observed these cells.A 1.7-kb fragment promoter murine HB-EGF linked to a luciferase reporter was strongly induced following ⌬Raf-1:ER, conditionally active form human Raf-1.Promoter ⌬Raf-1:ER required composite AP-1/Ets binding site located between bp ؊974 ؊988 upstream translation...
A Gram-stain-positive, spore-forming, obligately anaerobic bacterium, designated LAM201(T), was isolated from sediment samples an alkaline-saline lake located in Daqing oilfield, City, PR China. Cells of strain LAM201(T) were non-motile and straight or spiral rod-shapes. Strain able to utilize glucose, fructose, maltose, trehalose sorbitol as the sole carbon source. Acetic acid, ethanol, iso-butanoic acid iso-valeric main products glucose fermentation. The major fatty acids C(16 : 0) (26.7%)...
A Gram-staining-positive, spore-forming, strictly anaerobic bacterium, designated strain LAM0A37 T , was isolated from enrichment samples collected a petroleum reservoir in Shengli oilfield. Cells of were rod-shaped and motile by peritrichous flagella. The optimal temperature pH for growth 40 °C 7.0–7.5, respectively. did not require NaCl but tolerated up to 3 % (w/v) NaCl. Strain able utilize glucose, fructose, maltose, xylose, sorbitol, cellobiose, melibiose melezitose as sole carbon...
Proteolysis-targeting chimeras (PROTACs) based on the ubiquitin-proteasome system have made great progress in field of drug discovery. There is mounting evidence that accumulation aggregation-prone proteins or malfunctioning organelles associated with occurrence various age-related neurodegenerative disorders and cancers. However, PROTACs are inefficient for degradation such large targets due to narrow entrance channel proteasome. Macroautophagy (hereafter referred as autophagy) known a...
Herein, a novel fluorescent ionic covalent organic framework (BTTA-BDNP) based on linked carbazole unit was constructed for the synchronous monitoring and capture of TcO4-/ReO4-. BTTA-BDNP has fast fluorescence response time with low detection limit (66.7 nM) ReO4- (a non-radioactive substitute TcO4-). Meanwhile, high charge density hydrophobic skeleton enable it to exhibit rapid selective trapping in complex environments.
Macroautophagy/autophagy is a fundamental cellular catabolic process that delivers cytoplasmic components into double-membrane vesicles called autophagosomes, which then fuse with lysosomes and their contents are degraded. Autophagy recycles components, including misfolded proteins, dysfunctional organelles even microbial invaders, thereby playing an essential role in development, immunity cell death. Autophagosome formation the main step autophagy, governed by set of ATG (autophagy related)...
Photocatalysis is regarded as one of the most promising technologies to remove organic contaminants. At present, covalent frameworks (COFs) used photocatalysts are connected by imine or borate bonds, which have relatively low stability and poor π-delocalization. Herein, we report, for first time, vinylene-linked COFs constructed various diacetylene triazine moieties photocatalytic degradation contaminants disinfection bacteria. The pioneering introduction not only enhances conjugated...
Asthma is a chronic inflammatory pulmonary disease and respiratory syncytial virus (RSV) infection common cause of lower tract illness in infants young children. α-Asarone presents many pharmacological effects has been demonstrated to be useful treating asthma. However, the functional mechanism α-asarone RSV-infected asthma not investigated. Long non-coding RNAs (lncRNAs) have reported play critical roles biological processes. Although lncRNAs characterized, few were asthma, especially...
Abstract Spleen tyrosine kinase (SYK) is a non-receptor kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly understood. Here we identified E3 ligase TRIM31 as crucial regulator of activation. We found interacted with catalyzed K27-linked polyubiquitination at Lys375 Lys517 SYK. This promoted its plasma membrane translocation binding C-type lectin receptors (CLRs), also prevented interaction...
Heparin-binding epidermal growth factor-like factor (HB-EGF) gene expression and protein localization were analyzed during the process of myogenic differentiation. The mouse HB-EGF was isolated, a 1.8-kilobase genomic fragment flanking 5' end cDNA cloned. This contains two sequences which match consensus CANNTG sequence for E-boxes, binding sites MyoD family DNA-binding transcription factors that regulate myogenesis. Accordingly, synthesis in 10T1/2 cells C2C12 are used commonly study...
A series of unique indazoles and pyridoindolones have been rationally designed synthesized as novel classes cannabinoid ligands based on a proposed bioactive amide conformation. This has led to the discovery indolopyridone 3a conformationally constrained ligand that displays high affinity for CB2 receptor (K(i)(CB2) = 1.0 nM) possesses antiinflammatory properties when administered orally in an vivo murine inflammation model.
Abstract CARD9 is an essential adaptor protein in antifungal innate immunity mediated by C-type lectin receptors. The activity of critically regulated ubiquitination; however, the deubiquitinases involved regulation remain incompletely understood. In this study, we identified ovarian tumor deubiquitinase 1 (OTUD1) as regulator CARD9. OTUD1 directly interacted with and cleaved polyubiquitin chains from CARD9, leading to activation canonical NF-κB MAPK pathway. deficiency impaired...
Both acute myocarditis patients and normal cohort usually present with coronary computed tomography angiography (CCTA) performance, the performance of CCTA radiomics on prediction for is still unclear. This study aims to build a clinical model using CCTA-based radiomics. A total 215 consecutive from Affiliated Jinhua Hospital, Zhejiang University School Medicine (Center 1) Sir Run Shaw 2) who underwent were diagnosed as or enrolled. All images myocardium automatically segmented extract...
We investigated the dendritic relationship between starburst amacrine cells (SAs) and morphologically physiologically characterized ON ON-OFF direction-selective ganglion (DSGCs) in rabbit retina. DSGCs were found to exhibit tight cofasciculation with SA plexus, visualized by immunolabelling of vesicular acetylcholine transporter (VAChT). The degree both types DSGC dendrites plexus was be significant, unlike non-DS which close chance distribution. No difference different regions DS field...