A5080004695- Gas Sensing Nanomaterials and Sensors
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- ATP Synthase and ATPases Research
- Synthesis and Biological Evaluation
- Analytical Chemistry and Sensors
- Synthesis and biological activity
- ZnO doping and properties
- Luminescence Properties of Advanced Materials
- Gear and Bearing Dynamics Analysis
- MXene and MAX Phase Materials
- Traumatic Brain Injury and Neurovascular Disturbances
- Antimicrobial Peptides and Activities
- Tribology and Lubrication Engineering
- Perovskite Materials and Applications
- Mechanical and Optical Resonators
- Antibiotic Resistance in Bacteria
- Phenothiazines and Benzothiazines Synthesis and Activities
- 2D Materials and Applications
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Biochemical Acid Research Studies
- Pituitary Gland Disorders and Treatments
- Lubricants and Their Additives
- Graphene research and applications
Chongqing University
2015-2025
Research Institute of Petroleum Exploration and Development
2017-2025
First Affiliated Hospital of Wannan Medical College
2023-2025
QuantumWise (Denmark)
2025
Chemical Synthesis Lab
2025
Hunan University
2025
Guangzhou University
2018-2024
Department of Education of Guangdong Province
2023-2024
Anhui Agricultural University
2022-2024
Wuhan Botanical Garden
2024
Rapid, accurate, reliable, and risk-free tracking of pathogenic microorganisms at the single-cell level is critical to achieve efficient source control prevent outbreaks microbial infectious diseases. For first time, we report a promising approach for integrating concepts remarkably large Stokes shift dual-recognition into single matrix develop microorganism stimuli-responsive ratiometric fluorescent nanoprobe with speed, cost efficiency, stability, ultrahigh specificity, sensitivity. As...
To avoid carcinogenicity, formaldehyde gas, currently being only detected at higher operating temperatures, should be selectively in time with ppb concentration sensitivity a room-temperature indoor environment. This is achieved this work through introducing oxygen vacancies and Pt clusters on the surface of In2O3 to reduce optimal temperature from 120 40 °C. Previous studies have shown that water participates competitive adsorption sensor surface. Here, we experimentally confirm adsorbed...
New antibacterial 3-(aminothiazolyl)quinolones (ATQs) were designed and efficiently synthesized to counteract the growing multidrug resistance in animal husbandry. Bioactive assays manifested that N,N-dicyclohexylaminocarbonyl ATQ 10e methyl 17a, respectively, showed better behavior against Staphylococcus aureus ATCC 29213 Pseudomonas aeruginosa than reference drug norfloxacin. Notably, highly active 17a with low hemolysis, negligible mammalian cytotoxicity, good pharmacokinetic properties...
A unique class of antibacterial azolylpyrimidinediols (APDs) and their analogues were developed. Some synthesized compounds showed excellent bacteriostatic potency; especially, triazolylpyrimidinediol (triazolyl PD) 7a exhibited good anti-Acinetobacter baumannii potential with a low MIC 0.002 mmol/L. Triazolyl PD inconspicuous cytotoxicity hemolytic activity could eradicate the established biofilm, resistance, favorable drug-likeness. Mechanistic explorations revealed that compound without...
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. promotes the assembly removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how efficiently sequester Herein, we report undergoes reversible S-acylation in multiple human-, rat-, mouse-derived cell lines, catalyzed zinc-finger Asp-His-His-Cys S-acyltransferase 19 (ZDHHC19) deacylated acyl protein thioesterase 1 (APT1)....
This work identified a class of cyanomethylquinolones (CQs) and their carboxyl analogues as potential multitargeting antibacterial candidates. Most the prepared compounds showed high activities against most tested bacteria, exhibiting lower MIC values (0.125–2 μg/mL) than those clinical norfloxacin, ciprofloxacin, clinafloxacin. The low hemolysis, drug resistance, cytotoxicity, well good predictive pharmacokinetics active CQs revealed development potential. Furthermore, they could eradicate...
Graphitic carbon nitride (g-C3N4) nanosheets were exfoliated from bulk g-C3N4 and utilized to improve the sensing performance of a pure graphene sensor for first time. The role hydrochloric acid treatment on exfoliation result was carefully examined. products characterized by X-ray diffraction (XRD) patterns, scanning electron microscopy (SEM), atomic force (AFM), UV-Vis spectroscopy. exhibited uniform thickness about 3–5 nm lateral size 1–2 µm. A g-C3N4/graphene nanocomposite prepared via...
Abstract An organocatalytic one‐step desymmetrizing dearomatization reaction of indoles with in situ formed vinylidene ortho ‐quinone methides is reported. A set [6‐6‐5] and/or [5‐6‐5] fused indoline heterocycles were obtained excellent yields diastereoselectivities (>20:1 d.r.) and enantioselectivities (up to 99 % ee ). Moreover, some the products screened against a panel cancer cell lines, one was identified inhibit proliferation all tested cells, but showed marginal effects...
As one of the most promising biomarkers for numerous malignant tumors, accurate and reliable reporting Cathepsin B (CTSB) activity is great significance to achieve efficient diagnosis cancers at an early stage predicting metastasis. Here, we report a vigorous ratiometric fluorescent method integrating cancer-targeting recognition moiety with remarkably large emission wavelength shift into single matrix CTSB sensitively specifically. proof concept, synthesized amine-rich carbon quantum dots...