A5101580827- Cancer-related molecular mechanisms research
- Effects of Radiation Exposure
- Ultrasound and Hyperthermia Applications
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Mesenchymal stem cell research
- Cancer Genomics and Diagnostics
- Advanced Nanomaterials in Catalysis
- Hematopoietic Stem Cell Transplantation
- Chemical Synthesis and Reactions
- Gastric Cancer Management and Outcomes
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Pleural and Pulmonary Diseases
- Neutropenia and Cancer Infections
- Energy, Environment, Economic Growth
- Metal-Organic Frameworks: Synthesis and Applications
- Lignin and Wood Chemistry
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Neonatal Respiratory Health Research
- Flood Risk Assessment and Management
Nanjing Normal University
2025
Xiangya Hospital Central South University
2024-2025
Central South University
2019-2025
Heidelberg University
2022-2024
University Hospital Heidelberg
2022-2024
Chongqing University
2023-2024
Third Xiangya Hospital
2019-2023
Chongqing Medical and Pharmaceutical College
2023
Zhejiang A & F University
2022
Chengdu Second People's Hospital
2022
Pancreatic cancer is one of the most common malignant diseases in world. Gemcitabine chemotherapy remains important clinical treatment. However, research found that pancreatic cells have chemoresistance to gemcitabine and effect not satisfactory. Therefore, it urgent find an effective early diagnosis treatment strategy. Circular RNA popular prognostic biomarkers GEM-resistant PC. The present study was designed evaluate role circHIPK3 expression PC tissues its on proliferation, migration,...
p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into autophagosomes for degradation. promotes the assembly removal of ubiquitinated proteins by forming p62-liquid droplets. However, it remains unclear how efficiently sequester Herein, we report undergoes reversible S-acylation in multiple human-, rat-, mouse-derived cell lines, catalyzed zinc-finger Asp-His-His-Cys S-acyltransferase 19 (ZDHHC19) deacylated acyl protein thioesterase 1 (APT1)....
Gemcitabine (GEM) is one of the most widely chemotherapy drugs in PC. However, resistance always occurs after a period treatment indicating poor prognosis. lncRNA may play an essential role PC and serve as prognosis biomarkers with GEM-resistance. In our study, we aim to investigate HCP5 PC.QRT-PCR detected expression HCP5. The effects knockdown on proliferation, migration, invasion, cell apoptosis autophagy were investigated GEM-resistance cells. Bioinformatic analysis, luciferase reporter...
<title>Abstract</title> Numerous Pre-trained cell foundation models (CFM) have been developed to encapsulate the comprehensive gene-gene interaction network within cells, leveraging extensive single-cell sequencing data. These shown promise in various biology applications, including type annotation, perturbation inference, and state embedding, etc. However, their clinical utility, particularly cancer diagnosis prognosis, remains an open question. We introduce GeneBag model, a novel CFM that...
Singlet oxygen (1O2) is a widely used reactive species (ROS), making the development of new materials capable efficiently generating it highly important. In this work, we report series isostructural MOFs (named JNU‐300) that can spontaneously generate 1O2 by directly activating triplet (3O2) from air without need for additional light irradiation. The selective generation JNU‐300 verified electron paramagnetic resonance (EPR) spectroscopy and probe experiments 1O2. generated be employed...
Abstract Singlet oxygen ( 1 O 2 ) is a widely used reactive species (ROS), making the development of new materials capable efficiently generating it highly important. In this work, we report series isostructural metal‐organic frameworks (MOFs), named JNU‐300 (JNU = Jinan University), can spontaneously generate by directly activating triplet 3 from air without need for additional light irradiation. The selective generation verified electron paramagnetic resonance (EPR) spectroscopy and probe...
e16368 Background: Early and accurate prediction of pancreatic cancer progression is critical for optimizing treatment regimens improving patient prognosis, particularly in patients who do not exhibit significant remission during chemotherapy. This study aimed to develop a deep learning-based longitudinal disease monitoring model using multimodal data from routine clinical practice predict whether will experience at their next follow-up Methods: We developed learning baseline information CT...
e16444 Background: Tumor fibrosis significantly impacts chemotherapy efficacy in pancreatic ductal adenocarcinoma (PDAC), but its prognostic role remains unclear. This study aims to develop an artificial intelligence (AI)-based model for non-invasive prediction and explore relationship with efficacy. Methods: A three-phase was conducted, including quantification via whole slide images (WSIs), using preoperative CT images, evaluation of association outcomes. The surgical cohort included 123...
To investigate the alleviating effects of low-intensity pulsed ultrasound (LIPUS) on myelosuppression Sprague-Dawley rats with breast cancer induced by cyclophosphamide (CTX). Breast in was triggered intragastric gavage 7,12-dimethylbenz[a]anthracene (150 mg/kg). Then, were randomly allocated to LIPUS group (n=50) and control (n=50). The injected intraperitoneally CTX (50 mg/kg) for 4 consecutive days underwent treatment at femoral metaphysis 20 min per day from first injection 7 days....
The role of NR2F1-AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Therefore, we aimed to investigate the biological mechanism PDAC. expression was measured by using microarray data and real-time PCR. effects knockdown on proliferation, cell cycle progression, invasion vitro tumorigenesis vivo were investigated. competitive endogenous RNAs determined from bioinformatics analyses validated a dual-luciferase reporter gene assay. Potential target mRNAs TargetScan 7.2 selected for...
Transplantation and immunosuppressive therapies are the available treatments for aplastic anemia; however, each strategy has its advantages disadvantages.The aim of this study was to find a new anemia treatment.This an experimental comparative study.The model established by injecting rabbits with benzene cyclophosphamide. The were divided into low-intensity pulsed ultrasound (LIPUS) control groups. distal femoral metaphysis in LIPUS group treated 30 days (20 min/d), whereas received sham...
The oxidation of cyclohexylamine catalyzed by Al2O3-SiO2 catalyst was carried out under mild conditions. effects solvent amount, reaction time and temperature on the were investigated. Under conditions V(acetonitrile)∶V(cyclohexylamine)=3∶1, 31.0% mass fraction catalyst, 75 ℃, 5 h, conversion reaches up to 100% selectivity for cyclohexanone oxime is 83.6%. A mechanism proposed.
Pneumothorax is the most frequent complication in computed tomography-guided lung needle biopsy (CT-LNB) and generally appears immediately or within an hour after CT-LNB. Preventing pneumothorax CT-LNB requires a preoperative evaluation of risk factors. This study investigated factors for occurrence immediate CT-LNB.A total 311 procedures were conducted 290 patients (217 males 73 females) with persistent solid part-solid pulmonary lesions this case-control study. We retrospectively evaluated...
Our team has previously reported that low intensity pulsed ultrasound (LIPUS) can alleviate myelosuppression in rats induced by single chemotherapy drugs. But clinics, is often performed with multiple drugs simultaneously. To be closer to the clinical status quo, this experiment was designed show whether it same effect of LIPUS on caused combination therapy drugs.The rat model established continuous injection paclitaxel and carboplatin for 4 days. These myelosuppressive were randomly divided...
Background and Objective Postoperative pancreatic fistula (POPF) is the most common critical complication after pancreatoduodenectomy (PD) primary reason for increased mortality morbidity PD. We aim to investigate clinical significance of a novel approach, i.e., end-to-side one-layer continuous pancreaticojejunostomy, patients with Methods The data 65 who underwent at Xiangya Hospital, Central South University, from September 2020 December 2021 were retrospectively analyzed. Results Forty...