A5100380722- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Enzyme Structure and Function
- Advancements in Semiconductor Devices and Circuit Design
- Semiconductor materials and devices
- Biochemical and Molecular Research
- Eicosanoids and Hypertension Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Protein Structure and Dynamics
- Corporate Finance and Governance
- Pneumonia and Respiratory Infections
- Immune Cell Function and Interaction
- Dysphagia Assessment and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Microbial infections and disease research
- Oral Health Pathology and Treatment
- interferon and immune responses
- Melanoma and MAPK Pathways
- Vitamin C and Antioxidants Research
- Advanced MEMS and NEMS Technologies
- Bacteriophages and microbial interactions
- Protein Kinase Regulation and GTPase Signaling
- High-Energy Particle Collisions Research
Peking University
2013-2025
Central South University
2023-2025
Hunan Provincial Center for Disease Control and Prevention
2025
Third Xiangya Hospital
2025
Southwest University
2025
Wenzhou Medical University
2025
Chengdu University of Traditional Chinese Medicine
2025
Guizhou University of Finance and Economics
2024
Peking University Third Hospital
2018-2024
Zhejiang Provincial People's Hospital
2024
Non-alcoholic fatty liver disease is associated with obesity and considered an inflammatory disease. Soluble epoxide hydrolase (sEH) a major enzyme hydrolyzing epoxyeicosatrienoic acids attenuates their cardiovascular protective anti-inflammatory effects. We examined whether sEH inhibition can protect against high-fat (HF)-diet–induced in mice the underlying mechanism. Compared wild-type littermates, sEH-null showed lower diet-induced lipid accumulation liver, as seen by Oil-red O staining...
Hepatitis B virus (HBV) infection is a major global health problem. Currently-available therapies are ineffective in curing chronic HBV infection. and its satellite hepatitis D (HDV) infect hepatocytes via binding of the preS1 domain large envelope protein to sodium taurocholate cotransporting polypeptide (NTCP). Here, we developed novel human monoclonal antibodies that block engagement with NTCP neutralize HDV high potency. One antibody, 2H5-A14, functions at picomolar level exhibited...
Significance This study reveals that atheroprone flow induces integrin α5 translocation into lipid rafts and hence activation to cause endothelial dysfunction in vitro vivo. Consequently, this mechanotransduction event leads the of NLRP3 inflammasome. Knockdown ameliorated cell (EC) partially ligated carotid arteries Ldlr − / mice. Furthermore, haploinsufficiency or functional inhibition mice improved EC function area. These findings reveal a novel mechanism by which causes vascular...
Mycoplasma hyopneumoniae is the etiological agent of mycoplasmal pneumonia swine (MPS). Commercial vaccines provide partial protection and do not prevent colonization transmission M. hyopneumoniae. The bottleneck in development more effective for MPS stimulation immune responses host. purpose present study was to evaluate immunodominant proteins Mhp170, Mhp274 Mhp336 BALB/c mice. recombinant Mhp170 (rMhp170), (rMhp274), (rMhp336) were purified from bacteria. Fifty-two six-week-old SPF female...
Atherosclerosis resulting from hyperlipidemia causes many serious cardiovascular diseases. To understand the systems changes associated with pathogenesis and progression of atherosclerosis, we comprehensively analyzed dynamic metabonomic in multiple biological matrices LDLR(-/-) mice using NMR GC-FID/MS gene expression, clinical chemistry, histopathological data as well. We found that 12 week "Western-type" diet (WD) treatment caused obvious aortic lesions, macrophage infiltration, collagen...
Sodium taurocholate cotransporting polypeptide (NTCP) was identified as a functional receptor for hepatitis D virus (HDV) and its helper B (HBV). In cultured cell lines, HDV infection through mouse NTCP is restricted by residues 84 to 87 of the receptor. This study shows that mice with these three amino acids altered their corresponding human (H84R, T86K, S87N) in endogenous support de novo vivo documented presence replicative forms RNA proteins liver cells at day 6 after viral inoculation....
The objective of this study is to delineate disparities between patients with knee osteoarthritis (KOA) based on obesity status, investigate the interplay among body composition, physical activity and pain/function in KOA conduct subgroup analyses focusing those obesity. Cross-sectional study. Residents eight communities Shijiazhuang, Hebei Province, China, were surveyed from March 2021 November 2021. 178 symptomatic aged 40 years or older included. primary outcome measure was pain, assessed...
Background: A possible relationship between oral lichen planus (OLP) and thyroid disease has received attention in recent years. Objective: This study aimed to evaluate the correlation OLP diseases Chinese ethnic patients. Methods: 192 patients, 123 patients with lichenoid lesions (OLL), 162 controls were recruited this case-control study. All participants screening for function underwent ultrasound. Sex age of three groups matched. The prevalence subjects was analyzed. Using logistic...
Emerging evidence emphasized the role of oral microbiome in lichen planus (OLP). To date, no dominant pathogenic bacteria have been identified consistently. It is noteworthy that a decreased abundance Streptococcus, member lactic acid (LAB) OLP patients has commonly reported, indicating its possible effect on OLP. This study aims to investigate composition LAB genera by high-throughput sequencing, and explore relationship between them.
Diabetic nephropathy (DN) is a serious complication of diabetes, and inflammation plays crucial role. Sirtuin 2 (SIRT2), NAD+-dependent deacetylase, which involved in the regulation cell metabolism, proliferation longevity through deacetylation. Our previous research showed positive correlation between urinary SIRT2 levels renal injury markers DN patients. Therefore, this study explored specific role its regulatory relationship with inflammatory response. Increased expression was observed...
<title>Abstract</title> Numerous Pre-trained cell foundation models (CFM) have been developed to encapsulate the comprehensive gene-gene interaction network within cells, leveraging extensive single-cell sequencing data. These shown promise in various biology applications, including type annotation, perturbation inference, and state embedding, etc. However, their clinical utility, particularly cancer diagnosis prognosis, remains an open question. We introduce GeneBag model, a novel CFM that...
The purpose of the present study was to investigate effect Ganoderma lucidum polysaccharide (GLPS), a major active component in Chinese medicinal fungus, on cytochrome P450 metabolic activity Bacillus Calmette Guérin (BCG)-induced immune hepatic injury rats. enzyme kinetics probes including chlorzoxazone (CYP2E1), phenacetin (CYP1A2) and nifedipine (CYP3A) were evaluated by HPLC. results showed that BCG-pretreatment (125 mg/kg) significantly increased serum levels alanine transaminase (ALT),...
Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors HBV, HBV X protein (HBx) attracting increased attention. Although it documented that HBx multifunctional regulator modulates cell inflammation apoptosis, exact mechanism remains controversial. In present study, we explored effect on oxidative stress-induced apoptosis in normal line, HL-7702. Our results showed existence affected mitochon-drial biogenesis by modulating...
A monolithic integrated pressure-flow sensor with on-chip signal-conditioning CMOS circuit has been developed for simultaneous measurements of pressure and flow rates, which is used in automatic control system. Both the sensing are based on piezoresistive effect, only one additional mask applied to realize sensor. fully sensor, inter-COMS process, fabricated packaged. commercial computational fluid dynamics (CFD) software package, Fluent 6.1, model inside this The performance then predicted...
We study the production of $C=+$ charmonium states $X$ in ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\gamma}+X$ at $B$ factories with $X={\ensuremath{\eta}}_{c}(nS)$ ($n=1$, 2, 3), ${\ensuremath{\chi}}_{cJ}(mP)$ ($m=1$, 2), and $^{1}D_{2}(1D)$. In $S$- $P$-wave case, contributions QED one-loop QCD corrections are calculated within framework nonrelativistic (NRQCD), $D$-wave case only contribution is considered. find that most cases negative moderate, contrast to double...
HBx is a multifunctional regulator that interacts with host factors to contribute the development of hepatocellular carcinoma. In this study, explore co-localization and COXIII in HepG2 cells investigate molecular mechanism cell growth promotion, we first constructed line stably expressing gene vitro by lentivirus vectors. addition, found co-localized inner mitochondrial protein, COXIII, confocal laser scanning microscopy. It led changes biogenesis morphology, including upregulation protein...