A5100772716- Photoacoustic and Ultrasonic Imaging
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Mitochondrial Function and Pathology
- Advanced X-ray and CT Imaging
- Magnetic Properties and Synthesis of Ferrites
- Photoreceptor and optogenetics research
- Gold and Silver Nanoparticles Synthesis and Applications
- Tissue Engineering and Regenerative Medicine
- Thermography and Photoacoustic Techniques
- Spectroscopy and Chemometric Analyses
- Radiomics and Machine Learning in Medical Imaging
- Additive Manufacturing and 3D Printing Technologies
- Galectins and Cancer Biology
- Plant-based Medicinal Research
- Carbohydrate Chemistry and Synthesis
- Nerve injury and regeneration
- CRISPR and Genetic Engineering
- Solar-Powered Water Purification Methods
- Nanocluster Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Innovative Energy Harvesting Technologies
- Ectopic Pregnancy Diagnosis and Management
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2024
Wenzhou Medical University
2024
Case Western Reserve University
2023-2024
National Heart Lung and Blood Institute
2019-2023
National Institutes of Health
2019-2023
University School
2023
South China University of Technology
2023
Government of the United States of America
2023
Widefield photothermal microscopy enables ultrafast chemical imaging at submicrometer spatial resolution.
The ability to fabricate perfusable, small-diameter vasculature is a foundational step toward generating human tissues/organs for clinical applications. Currently, it highly challenging generate integrated with smooth muscle and endothelium that replicates the complexity functionality of natural vessels. Here, novel method directly printing self-standing, presented through combining tailored mussel-inspired bioink unique 'fugitive-migration' tactics, its effectiveness advantages over other...
Abstract Stimulated Raman scattering (SRS) microscopy allows for high-speed label-free chemical imaging of biomedical systems. The sensitivity SRS is limited to ~10 mM endogenous biomolecules. Electronic pre-resonant detection sub-micromolar chromophores. However, single biomolecules having extremely small cross-sections (~10 −30 cm 2 sr −1 ) remains unreachable. Here, we demonstrate plasmon-enhanced stimulated (PESRS) with single-molecule sensitivity. Incorporating pico-Joule laser...
Nanoprobes with dual modal imaging of magnetic resonance (MRI) and two-photon fluorescence (TPF) can serve as promising platforms for clinical diagnosis. A wide range molecules nanoparticles have been investigated agents contrast enhanced MRI in cancer However, a single material TPF is rarely reported. We found that Mn3[Co(CN)6]2 nanocubes both T1- T2-weighted imaging. The coated silica to form Mn3[Co(CN)6]2@SiO2 core-shell were readily internalized by cells without showing cytotoxicity. In...
Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters large device diameter ∼25 mm typical sub-MHz technology suffered from diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) developed, serving as miniaturized point source, with...
Somatostatin analogues (SSTA) are first-line pharmacological treatment choice for acromegaly, which received satisfying tumor shrinkage and normalization of growth hormone.However, there still patients unresponsive to SSTA, the underline mechanism remains unknown.Besides, is no evidence regarding role endoplasmic reticulum stress (ERS) its transmission in SSTA resistance, also require investigation.Primary hormone adenoma cells cell lines were treated with SSTA; autophagy double-labeled LC3...
Both acute myocarditis patients and normal cohort usually present with coronary computed tomography angiography (CCTA) performance, the performance of CCTA radiomics on prediction for is still unclear. This study aims to build a clinical model using CCTA-based radiomics. A total 215 consecutive from Affiliated Jinhua Hospital, Zhejiang University School Medicine (Center 1) Sir Run Shaw 2) who underwent were diagnosed as or enrolled. All images myocardium automatically segmented extract...
Abstract Biomaterial scaffold designs are needed for self‐organizing features related to tissue formation while also simplifying the fabrication processes involved. Toward this goal, silk protein‐based self‐folding scaffolds support 3D cell culture, providing directional guidance and promotion of growth differentiation, reported. A simple robust one‐step approach is developed using bilayers consisting a hydrogel film in aqueous solution. The rolls, with patterns transferred from initially...
Abstract Background Human mitochondrial DNA mutations are associated with common to rare disorders, which multisystemic complex clinical pathologies. The pathologies of these diseases poorly understood and have no FDA-approved treatments leading symptom management. Leigh syndrome (LS) is a pediatric disorder that affects the central nervous system during early development causes death in infancy. Since there adequate models for understanding rapid fatality LS, human-induced pluripotent stem...
Plasmon-enhanced coherent Raman scattering microscopy has reached single-molecule detection sensitivity. Due to the different driven fields, there are significant differences between a process and its plasmon-enhanced derivative. The commonly accepted line shapes for anti-Stokes stimulated do not hold condition. Here, we present theoretical model that describes spectral in (PECARS). Experimentally, measured PECARS (PESRS) spectra of 4-mercaptopyridine adsorbed on self-assembled Au...
Despite being promising photovoltaic materials, widespread use of organic-inorganic halide perovskite materials is still hindered by their undesirable stability. To cope with this challenge, methylamine (MA) doped into triple cation single crystals (FA0.95-x MA x Cs0.05)PbI3, and cesium-containing five different molar ratios (x = 0, 0.05, 0.10, 0.15, 0.20) are synthesized characterized. Among them, (FA0.8MA0.15Cs0.05)PbI3 shows high stability against water-oxygen light for 60 days, the...
Hemozoin, the heme detoxification end product in malaria parasites during their growth red blood cells (RBCs), serves as an important marker for diagnosis and treatment target of disease. However, current method hemozoin-targeted drug screening mainly relies on vitro β-hematin inhibition assays, which may lead to false-positive events due under-representation real hemozoin crystal. Quantitative situ imaging is highly desired high-throughput antimalarial drugs elucidating mechanisms drugs. We...
After injuries, axonal regeneration over long distance is challenging due to lack of orientation guidance. Biocompatible scaffolds have been used mimic the native organization axons guide and facilitate regeneration. Those are great importance in achieving functional connections nervous system. We developed a nanoladder scaffold directional outgrowth axons. The nanoladders, composed micron-scale stripes nanoscale protrusions, were fabricated on glass substrate using photolithography reactive...
The scaffolds prepared from the tissue decellularization conserve porous 3-D structure and provide an optimal matrix for regeneration. Since decade, enzymatic digestion, chemical reagent treatment mechanical actions such as eve
Abstract Neuromodulation is an invaluable approach for study of neural circuits and clinical treatment neurological diseases. Here, we report semiconducting polymer nanoparticles based photoacoustic nanotransducers (PANs) stimulation. Our PANs strongly absorb light in the near-infrared second window generate localized acoustic waves. can also be surface-modified to selectively bind onto neurons. PAN-mediated activation primary neurons vitro achieved with ten 3-nanosecond laser pulses at 1030...
<title>Abstract</title> Background This study aimed to analyze the correlation factors of spontaneous preterm birth in twin pregnancies and construct a predictive model, with hope providing clinical value for prediction delivery pregnancies. Methods A total 218 pregnant women at Jiaxing Women Children's Hospital, Wenzhou Medical University between June 2021 May 2024 were enrolled. One-way Analysis Variance (One-way ANOVA) multivariate logistic regression analysis used factors, model was...
Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in specimen. The performance, however, is limited terms of spatial resolution and speed. Here, instead measuring the loss IR beam, we utilize pulsed visible light high-throughput, widefield sensing transient photothermal effect induced by absorption single mid-IR pulses. To extract such signals, built virtual lock-in camera synchronized to probe pulses with precisely-controlled delays, allowing...