A5051721764- Head and Neck Cancer Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Effects of Radiation Exposure
- Archaeological Research and Protection
- Cardiac tumors and thrombi
- Digital Humanities and Scholarship
- Oral health in cancer treatment
- Nutrition and Health in Aging
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Risks and Factors
- Systemic Lupus Erythematosus Research
- Brain Metastases and Treatment
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Tumors and Oncological Cases
- Venous Thromboembolism Diagnosis and Management
Nanjing University
2019-2024
State Key Laboratory of Oncology in South China
2018-2023
Sun Yat-sen University
2016-2023
Sun Yat-sen University Cancer Center
2016-2023
Key Laboratory of Guangdong Province
2023
Nanjing General Hospital of Nanjing Military Command
2019
Sun Yat-sen Memorial Hospital
2018
To evaluate the clinical outcome in patients with de novo metastatic nasopharyngeal carcinoma (NPC) treated or not locoregional radiotherapy (LRRT) based on plasma Epstein–Barr virus (EBV) DNA level and tumor response after palliative chemotherapy (PCT). From 2007 to 2016, 502 NPC were included this study. All PCT 315 received LRRT. Our primary study endpoint was overall survival (OS). EBV detected 461 (91.8%) before treatment but undetectable 249 (49.6%) PCT. Three hundred seventeen (63.1%)...
Abstract Background Currently, the diagnosis and treatment of nasopharyngeal carcinoma (NPC) patients with residual cervical lymphadenopathy following radical radiotherapy or without chemotherapy are challenging. We investigated prognosis NPC assessed diagnostic prognostic values Epstein‐Barr virus (EBV) DNA in these patients. Methods This study included 82 who were diagnosed suspected completion antitumor therapy. Their plasma EBV levels measured using quantitative polymerase chain reaction...
The purpose of this study was to subdivide M1 stage nasopharyngeal carcinoma (NPC) patients with bone-only metastases for prognosis prediction while identifying the treatment effect locoregional radiotherapy (LRRT) and metastasis (MRT) among different risk.From November 2006 October 2016, a total 226 metastasic NPC were retrospectively enrolled. All developed distant lesions before receiving treatment. potential prognostic factors considered correlation subdivisions overall survival (OS)...
Objective: This study aimed to establish a nomogram predict the risk of post-radiation necrosis in nasopharyngeal carcinoma (NPC) patients. Background: was performed identify influencing factors for developing necrosis, and an effective model individual risks NPC Methods: 7144 patients receiving radical radiotherapy from 2007 2012 were involved study, 207 them developed (NPN). The clinical characteristics baseline laboratory results collected analyzed. Independent predictive selected using...
Body mass index (BMI) has a U-shaped association with lung cancer risk. However, the effect of BMI on prognosis is controversial. This retrospective study aimed to investigate survival patients stage I non-small cell (NSCLC) after surgical resection. In total, 624 consecutive NSCLC who underwent radical resection were classified into four groups according their BMI: underweight (BMI < 18.5 kg/m2), normal weight = 18.5–22.4 overweight 22.5–28.0 and obese > 28.0 kg/m2). The progression-free...
Abstract Object To ascertain the treatment effect of concurrent chemotherapy (CCT) in stage II‐III nasopharyngeal carcinoma (NPC) patients with different Epstein‐Barr virus (EBV) DNA level intensity‐modulated radiotherapy (IMRT) era. Methods A total 2742 diagnosed NPC were involved this study. Patients received IMRT with/without CCT. Overall survival (OS) was primary endpoint. Receiver operating characteristics curve used to determine cut‐off value pre‐DNA based on OS. After propensity score...
Objectives: To evaluate the prognostic significance of Adult Comorbidity Evaluation-27 (ACE-27) for elderly patients (age ≥70 years) with locoregionally advanced nasopharyngeal carcinoma (NPC) treated Intensity-Modulated Radiotherapy (IMRT), or without chemotherapy.Methods: 206 NPC from December 2006 to 2016 were involved into analysis as training cohort.Besides, a separate cohort 72 same cancer center collected between January 2003 and October served validation cohort.By using propensity...
No nomogram has been established for de novo metastatic NPC patients previously. Thus, we retrospectively involved 502 to develop a practical clinical tool by combining prognostic biomarkers estimate individual risk.The was based on primary cohort involving 353 from 2007 2013; all independent factors were integrated inclusion in the model. The predictive accuracy of model evaluated concordance index (C-index). A calibration curve used compare predicted and observed survival. We confirmed...
Purpose The purpose of this study was to investigate the survival trends and patterns failure in patients with stage II nasopharyngeal carcinoma (NPC) treated radiotherapy (RT) chemotherapy over last 20 years. Materials Methods Thirty-eight hundred eight diagnosed NPC between January 1990 December 2012 were involved retrospective cohort study. All RT. According main imaging techniques RT technology, we categorized these into four calendar periods: 1990-1996, 1997-2002, 2003-2007, 2008-2012....
Despite increasing use, symptomatic venous thromboembolism (VTE) associated with peripherally inserted central catheter (PICC) is a common complication in nonmetastatic nasopharyngeal carcinoma (NPC) patients. A total of 3012 NPC patients were enrolled this retrospective study, and we applied Cox regression log-rank tests to assess the association between PICC-VTE survival using propensity score method (PSM) adjust for gender, age, radiotherapy technique, tumor stage, node UICC clinical...
This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels in de novo metastatic nasopharyngeal carcinoma (NPC) patients.From December 2006 2016, 253 NPC patients assessed by PET/ computed were involved current study. SUVmax-T, SUVmax-N, and SUVmax-M referred SUVmax at primary tumor, cervical lymph nodes, lesions respectively. Overall survival...
Epidemiological studies have suggested a potential role for sex hormones in esophageal squamous cell carcinoma (ESCC) etiology. However, the significance of gender as an independent prognostic factor remains uncertain. Our retrospective study was designed to investigate survival after esophagectomy.
Background: To assess the prognosis of neck residue nasopharyngeal carcinoma (NPC) patients and efficacy dissection in treatment these patients.Methods: We recruited 68 NPC patients.For each patient we had three matched without as controls (n = 204).The primary endpoint was progression-free survival (PFS).The Cox proportional hazards model used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), multivariable analysis test independent statistical significance...
Objectives/Hypothesis The routine practices of examining submucosal lesions are not suitable for deep lesions. Therefore, we evaluated the efficacy non‐real‐time image‐guided transnasal endoscopic fine‐needle aspiration biopsy (FNAB) in diagnosing nasopharyngeal carcinoma (NPC) with Study Design effectiveness evaluation diagnostic methods. Methods Fifty suspected NPC patients who failed conventional biopsies were enrolled this study. efficacy, maneuverability, and safety FNAB these...
Abstract Objective This study aimed to select optimal candidates benefiting from the addition of induction chemotherapy (IC) concurrent chemoradiotherapy (CCRT) in stage II–IVa nasopharyngeal carcinoma (NPC) based on Epstein–Barr virus (EBV) DNA and nodal maximal standardized uptake values (SUVmax‐N) [ 18 F]‐fluorodeoxyglucose positron emission tomography. Patients materials A total 679 patients diagnosed with (except N0) NPC were retrospectively included this study. Overall survival was...
The purpose of this study was to explore the risk factors for renal survival in patients with severe Lupus nephritis treated continuous replacement therapy (CRRT). Two hundred and forty-seven SLE (male 54, female 193, median age 30.0(23-41) years requiring CRRT from January 2009 December 2016 Jinling Hospital were included study. 152(61.54%) achieved dialysis independence (dialysis independent group);95(38.46%) on maintenance dependent group). multivariate COX regression analysis revealed...