A5101982871- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Nuclear physics research studies
- Quantum Chromodynamics and Particle Interactions
- Nuclear Physics and Applications
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Advanced Measurement and Metrology Techniques
- Scientific Measurement and Uncertainty Evaluation
- Particle physics theoretical and experimental studies
- Atomic and Molecular Physics
- Digital Radiography and Breast Imaging
- Advanced Sensor Technologies Research
- Nuclear reactor physics and engineering
- Advanced NMR Techniques and Applications
- Combustion and Detonation Processes
- Tumors and Oncological Cases
- Pleural and Pulmonary Diseases
- Quantum, superfluid, helium dynamics
- Radioactive contamination and transfer
- Carcinogens and Genotoxicity Assessment
- Ultrasound and Hyperthermia Applications
- Boron Compounds in Chemistry
- Burn Injury Management and Outcomes
Sun Yat-sen University
2020-2025
Sun Yat-sen University Cancer Center
2020-2025
Chinese Academy of Sciences
2025
North Sichuan Medical University
2025
Nanchong Central Hospital
2025
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Peking University
2010-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
State Key Laboratory of Nuclear Physics and Technology
2021-2023
PurposeThis study aimed to evaluate whether high-energy X-rays (HEXs) of the PARTER (platform for advanced radiotherapy research) platform built on CTFEL (Chengdu THz Free Electron Laser facility) can produce ultrahigh dose rate (FLASH) and trigger FLASH effect.Materials methodsEBT3 radiochromic film fast current transformer (FCT) devices were used measure absolute pulsed beam HEXs. Subcutaneous tumor-bearing mice healthy treated with sham, FLASH, conventional (CONV), respectively observe...
Ultrahigh dose-rate irradiation (FLASH-IR) was reported to be efficient in tumor control while reducing normal tissue radiotoxicity. However, the mechanism of such phenomenon is still unclear. Besides, FLASH experiments using high energy X-ray, most common modality clinical radiotherapy, are rarely reported. This study aims investigate radiobiological response 6 MV X-ray FLASH-IR or conventional IR (CONV-IR).The superconducting linac Chengdu THz Free Electron Laser (CTFEL) facility used for...
The cellular response to ionizing radiation continues be of significant research interest in cancer radiotherapy, and DNA is recognized as the critical target for most biologic effects radiation. Incident particles can cause initial damages through physical chemical interactions within a short time scale. Initial undergo repair via different pathways available at stages cell cycle. misrepair damage results genomic rearrangement causes mutations chromosome aberrations, which are drivers...
Microdosimetric energy depositions have been suggested as a key variable for the modeling of relative biological effectiveness (RBE) in proton and ion radiation therapy. However, microdosimetry has underutilized Recent advances detector technology allow design new mico- nano-dosimeters. At same time Monte Carlo (MC) simulations become more widely used In order to address growing interest field, microdosimetric extension was developed TOPAS. The provides users with functionality simulate...
Monte Carlo (MC) track structure simulation tools are commonly used for predicting radiation induced DNA damage by modeling the physical and chemical reactions at nanometer scale.However, outcome of these MC simulations is particularly sensitive to adopted parameters which vary significantly across studies.In this study, a previously developed full model nuclear was describe geometry.The TOPAS-nBio toolkit investigate impact physics chemistry models as well three key (the energy threshold...
Abstract Purpose The ultra-high dose rate (UHDR) radiation shows promise in eradicating tumors while reducing normal tissue toxicities. However, the biological outcomes of UHDR are influenced by various factors, particularly mean and instantaneous rate. Additionally, response at large field sizes is lacking. This study aimed to explore impact different combinations on gastrointestinal following total-body irradiations (TBI) examine involved molecular signaling pathways. Method Female...
Abstract A new inelastic excitation and cluster-decay experiment was conducted in order to investigate the negative-parity linear-chain structure 16 C. The helium beryllium isotopes emitted from highly excited states of C recoil target deuteron were detected coincidence. excitation-energy spectra associated with different decay paths have been reconstructed using invariant mass method. Owing newly reconfigured detector setup, detection acceptance extended higher range, allowing observe a...
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as FLASH effect. This study performed theoretical analyses about impact of radiolytic oxygen depletion (ROD) on cellular responses after irradiation. Methods: Monte Carlo simulation was used to model ROD process, determine DNA damage, calculate amount depleted (LROD) during exposure. A mathematical applied analyze...
We have extracted QCD matrix elements from our data on doubly polarized inelastic scattering of electrons nuclei.We find the higher twist element d2, which arises strictly quarkgluon interactions, to be unambiguously non zero.The also reveal an isospin dependence effects if we assume that Burkhardt-Cottingham Sum rule is valid.The fundamental Bjorken sum obtained a0 satisfied at low momentum transfer.
Ultra-high dose rate FLASH irradiation (FLASH-IR) has been shown to cause less normal tissue damage compared with conventional (CONV-IR), this is known as the "FLASH effect." It attracted immense research interest because its underlying mechanism scarcely known. The purpose of study was determine whether FLASH-IR and CONV-IR induce differential inflammatory cytokine expression using a modified clinical linac.An Elekta Synergy linac used deliver 6 MeV FLASH-IR. Female FvB mice were randomly...
Experimental results of the $^{1}\mathrm{H}(^{13}\mathrm{B},d)^{12}\mathrm{B}$ transfer reaction to low-lying states in $^{12}\mathrm{B}$ are reported. The optical potential parameters for entrance channel extracted from elastic scattering $^{1}\mathrm{H}(^{13}\mathrm{B},\phantom{\rule{0.16em}{0ex}}p)$ measured same experiment, while those exit global ones. Spectroscopic factors associated with $p$-, $s$-, and $d$-wave neutron known by comparing deuteron angular distributions calculation...
We investigate the low-lying positive-parity states in $^{12}\mathrm{Be}$, which are populated by $^{2}\mathrm{H}(^{13}\mathrm{B}$, $^{3}\mathrm{He})$ reaction via $l=1$ proton transfer for first time using a radioactive beam $^{13}\mathrm{B}$ at 23 MeV/nucleon. Spectroscopic factors and excitation energies of these reasonable agreement with shell model predictions. Besides two bound states, we observe resonant state...
This paper discusses the generation of a novel periodic nonlinear error in homodyne interferometers due to geometric misalignments. These misalignments arise from cumulative assembly errors among sensor head interior, target mirror, test platform, and detector, leading dynamic misplacement measurement beam on detector's surface. A physical model was developed explain this error, focusing interference field produced by Gaussian beams under conditions separation inclined interference....
Abstract Background Ultra‐high dose rate (FLASH) radiation has been reported to efficiently suppress tumor growth while sparing normal tissue; however, the mechanism of differential tissue effect is still not known. Oxygen long known profoundly impact radiobiological responses, and radiolytic oxygen depletion considered be a possible cause or contributor FLASH phenomenon. Purpose This work investigates pO 2 profiles, per unit ( g ), concentration yielding half‐maximum radiosensitization (the...
ABSTRACT Ultrahigh dose-rate (FLASH) radiotherapy has attracted immense attention because of its tumor control efficiency and healthy tissue protection during preclinical experiments with electrons, kilo-voltage X-rays, protons. Using high-energy X-rays (HEXs) in FLASH is advantageous owing to deep penetration, small divergence, cost-effectiveness. This the first report on implementation HEXs (HEX-FLASH) corresponding application vivo . With a high-current superconducting linear accelerator,...
The human eye lens is sensitive to radiation. ICRP-118 publication recommended a reduction of the occupational annual equivalent dose limit from 150 20 mSv, averaged over defined periods 5 y. Therefore, it very important build detailed model for accurate assessment and radiation risk evaluation lens. In this work, was based on characteristic anatomic parameters Chinese adult male. This includes seven main structures, which are scleral, choroid, lens, iris, cornea, vitreous body aqueous...