A5025216680- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Inflammatory Biomarkers in Disease Prognosis
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Peptidase Inhibition and Analysis
- Thyroid and Parathyroid Surgery
- Oral Health Pathology and Treatment
- Cancer survivorship and care
- scientometrics and bibliometrics research
- Head and Neck Anomalies
- Family Support in Illness
- Schizophrenia research and treatment
- Esophageal Cancer Research and Treatment
- Colorectal and Anal Carcinomas
- Oropharyngeal Anatomy and Pathologies
- Viral-associated cancers and disorders
- Radiation Therapy and Dosimetry
- Mental Health via Writing
- AI in cancer detection
Sun Yat-sen University
2021-2024
Sun Yat-sen University Cancer Center
2021-2024
State Key Laboratory of Oncology in South China
2021-2024
Guangzhou Medical University
2019-2022
Southern Medical University
2022
University of Colorado Denver
2022
University of Colorado Cancer Center
2022
Guangzhou Medical University Cancer Hospital
2020-2021
Abstract Background Images from magnetic resonance imaging (MRI) are crucial unstructured data for prognostic evaluation in nasopharyngeal carcinoma (NPC). We developed and validated a system based on the MRI features clinical of locoregionally advanced NPC (LA-NPC) patients to distinguish low-risk with LA-NPC whom concurrent chemoradiotherapy (CCRT) is sufficient. Methods This multicenter, retrospective study included 3444 January 1, 2010, 31, 2017. A 3-dimensional convolutional neural...
6041 Background: Managing metastatic nasopharyngeal carcinoma (mNPC) remains challenging due to its high incidence and mortality rates. While maintenance therapy shows promising potential, the optimal strategy unclear. A prior ranking question is if combined of anti-PD-1 antibodies capecitabine an effective for mNPC patients who achieved disease control after first-line therapy. Methods: Eligible with following subsequently received were included at Sun Yat-sen University Cancer Center...
Dysregulation of lipid metabolism is closely associated with cancer progression. The study aimed to establish a prognostic model predict distant metastasis-free survival (DMFS) in patients nasopharyngeal carcinoma (NPC), based on lipidomics.The plasma profiles 179 locoregionally advanced NPC (LANPC) were measured and quantified using widely targeted quantitative lipidomics. Then, randomly split into the training (125 patients, 69.8%) validation (54 30.2%) sets. To identify...
The treatment of anaplastic lymphoma kinase (ALK)-positive locally advanced non-small-cell lung cancer (NSCLC) is challenging because there no randomized controlled trial has been reported. value neoadjuvant and adjuvant targeted therapy remains unclear. Herein, we show that systemic with ALK inhibitor crizotinib before surgery can provide the potential to cure initially inoperable tumor. A 27-year-old man was diagnosed a stage IIIAcT3N2M0 (7 th UICC/AJCC) upper left adenocarcinoma harboring...
Patients with residual nasopharyngeal carcinoma after receiving definitive treatment have poor prognoses. Although immune checkpoint therapies achieved breakthroughs for treating recurrent and metastatic carcinoma, none of these strategies been assessed carcinoma. In this single-arm, phase 2 trial, we aimed to evaluate the antitumor efficacy safety toripalimab (anti-PD1 antibody) plus capecitabine in patients (ChiCTR1900023710). Primary endpoint trial was objective response rate according...
Abstract Hepatic metachronous oligometastatic nasopharyngeal carcinoma (hmoNPC) exhibits distinct clinical characteristics compared to other types of metastatic NPC. We investigated the optimal therapy for hmoNPC. 160 patients with hmoNPC treated in Sun Yat‐sen University Cancer Center between 2010 and 2021 were retrospectively recruited. A total 56 classified into local (LT) cohort, 23 systemic (ST) cohort 81 combination (LT + ST) cohort. The median PFS was 7.9 months (95% confidence...
Aims: This study aimed to investigate the clinical value of induction chemotherapy (IC) with docetaxel, 5-fluorouracil plus nedaplatin followed by concurrent chemoradiotherapy (CCRT) for locoregional advanced nasopharyngeal carcinoma (NPC).Materials and Methods: In total, 269 patients diagnosed NPC between June 2012 2017 were retrospectively included divided into two groups: IC (docetaxel 5-fluorouracil) nedaplatin-based CCRT (TNF + N group, n = 146) cisplatin cisplatin-based (TPF P 123).The...
Objective: To investigate the clinical value of induction chemotherapy (IC) with docetaxel plus cisplatin (TP) followed by concurrent chemoradiotherapy (CCRT) TP in locoregionally advanced nasopharyngeal carcinoma (NPC).Methods: A total 544 patients NPC that was newly diagnosed from January 2009 to December 2015 were included this study.Among these patients, 251 treated CCRT (DDP) alone (TP + DDP group), 167 and 126 docetaxel, fluorouracil (TPF) (TPF group).Overall survival (OS), distant...
This study aims to evaluate the value of a serum metabolomics-based metabolic signature for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients, thereby assisting clinical decisions.In this retrospective study, total 320 LA-NPC patients were randomly divided into training set (ca. 70%; n = 224) and validation 30%; 96). Serum samples analyzed using widely targeted metabolomics. Univariate multivariate Cox regression analyses used identify candidate metabolites related...
To develop and validate a predictive nomogram for tumor residue 3-6 months after treatment based on postradiotherapy plasma Epstein-Barr virus (EBV) deoxyribonucleic acid (DNA), clinical stage, radiotherapy (RT) dose in patients with stage II-IVA nasopharyngeal carcinoma (NPC) treated intensity-modulated radiation therapy (IMRT).In this retrospective study, 1050 eligible NPC, who completed curative IMRT underwent pretreatment (-7 to +28 days IMRT) EBV DNA testing, were enrolled from 2012...
Two cycles of induction chemotherapy (IC) followed by 2 platinum-based concurrent chemoradiotherapy (CCRT) (2IC+2CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) is widely adopted but not evidence-confirmed. This study aimed to determine the clinical value 2IC+2CCRT regarding efficacy, toxicity and cost-effectiveness.This real-world from two epidemic centers used propensity score matching (PSM) inverse probability treatment weighting (IPTW) analyses. The enrolled patients...
Abstract Objectives This study aimed to investigate the incidence, consequences, and predictors of serious chemotherapy‐induced thrombocytopenia (CIT) in nasopharyngeal carcinoma (NPC). Materials Methods We retrospectively reviewed clinical records patients with NPC between 2013 2015. Multivariate Cox proportional hazards regression model propensity score matching were used estimate effect CIT on overall survival. Univariate multivariate logistic analyses applied identify CIT. Results...
Locoregional recurrence of nasopharyngeal carcinoma (NPC) occurs in 10% to 50% cases following primary treatment. However, the current main prognostic markers for NPC, both stage and plasma Epstein-Barr virus DNA, are not sensitive locoregional recurrence. We gathered 385 whole-slide images (WSIs) from haematoxylin eosin (H&E)-stained NPC sections (n = 367 cases), which were collected Sun Yat-sen University Cancer Centre. developed a deep learning algorithm detect tumour nuclei lymphocyte...
To investigate whether the addition of fluorouracil to docetaxel and cisplatin induction chemotherapy (IC) can truly improve prognosis patients with locoregionally advanced nasopharyngeal carcinoma (NPC).
Background The optimal second-line systemic treatment model for recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) remains controversial. A Bayesian network meta-analysis (NMA) was performed to address this issue with regard efficacy toxicity. Methods By searching MEDLINE ( via PubMed), Embase, the Cochrane Central Register of Controlled Trials Web Science, we extracted eligible studies. Efficacy, represented as overall survival (OS) progression-free (PFS),...
6071 Background: Although several large phase III clinical trials and meta-analysis have demonstrated significant benefit of docetaxel combined with cisplatin 5-FU (TPF) chemotherapy in head neck cancer, serious adverse reactions are unsatisfactory. Therefore, this study was designed to evaluate the efficacy safety nab-paclitaxel plus (TP) versus TPF induction (ICT) followed by concurrent chemoradiotherapy (CCRT) for locally advanced nasopharyngeal carcinoma (LA-NPC). Methods: In open-label,...
It is imperative to optimally utilize virtues and obviate defects of fully automated analysis expert knowledge in new paradigms healthcare. We present a deep learning-based semiautomated workflow (RAINMAN) with 12,809 follow-up scans among 2,172 patients treated nasopharyngeal carcinoma from three centers (ChiCTR.org.cn, Chi-CTR2200056595). A boost diagnostic performance reduced workload was observed RAINMAN compared the original manual interpretations (internal vs. external: sensitivity,...
To evaluate the prognostic effect of pretreatment serum superoxide dismutase (SOD) activity in locoregionally advanced nasopharyngeal carcinoma.A total 498 patients diagnosed with stage III-IVA carcinoma between January 2013 and December 2016 were involved this study. The X-tile program was used to determine cut-off value SOD based on disease-free survival. Kaplan-Meier methods Cox proportional hazards models impact levels survival outcomes. receiver operating characteristic (ROC) curve...
Abstract Purpose: The efficacy and safety of nimotuzumab (NTZ) added to concurrent chemoradiotherapy (CCRT) was investigated in patients with stage III-IVa nasopharyngeal carcinoma (NPC). Methods: Patients NPC treated CCRT, or without NTZ, were screened between January 2015 December 2017. Overall survival (OS), progression-free (PFS), locoregional recurrence-free (LRFS), distant metastasis-free (DMFS) compared these groups. Propensity score matching (PSM) applied reduce the selection bias....
Abstract Precise detection of recurrence in patients with treated nasopharyngeal carcinoma (NPC) facilitates timely intervention and prolongs survival. However, there is no compelling tool realizing real-time precise as scale hitherto. Here we present a deep learning-based sequential scan model called RAIN, harnessing 10,212 time-series follow-up head neck magnetic resonance (MR) scans 1,808 NPC multicenter observational study (Blinded ID). The RAIN yields larger area under the receiver...