A5046936238- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Intracerebral and Subarachnoid Hemorrhage Research
- Brucella: diagnosis, epidemiology, treatment
- Acute Ischemic Stroke Management
- RNA modifications and cancer
- Multiple Sclerosis Research Studies
- Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Cancer-related molecular mechanisms research
- Oral health in cancer treatment
- COVID-19 Clinical Research Studies
- Oral and Maxillofacial Pathology
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Burkholderia infections and melioidosis
- Antibiotic Resistance in Bacteria
- Head and Neck Cancer Studies
- Cancer Cells and Metastasis
- Autoimmune Neurological Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Acute Kidney Injury Research
- Animal Diversity and Health Studies
- Optimal Power Flow Distribution
- Quinazolinone synthesis and applications
Sichuan University
2014-2025
West China Second University Hospital of Sichuan University
2021-2025
Guangzhou Medical University Cancer Hospital
2025
Guangzhou Medical University
2025
State Key Laboratory of Oral Diseases
2019-2024
Capital Medical University
2016-2024
Union Hospital
2021-2024
Huazhong University of Science and Technology
2021-2024
Beijing Children’s Hospital
2024
Wuhan Union Hospital
2024
Abstract As an important component of the tumor microenvironment, cancer-associated fibroblasts (CAFs) secrete energy metabolites to supply for progression. Abnormal regulation long noncoding RNAs (lncRNAs) is thought contribute glucose metabolism, but role lncRNAs in glycolysis oral CAFs has not been systematically examined. In present study, by using RNA sequencing and bioinformatics analysis, we analyzed lncRNA/mRNA profiles normal (NFs) derived from tissues patients with squamous cell...
Abstract Background The faithful maintenance of DNA methylation homeostasis indispensably requires methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squamous cell carcinoma (OSCC). However, how the DNMT1- associated global is exploited to regulate OSCC remains unclear. Methods shRNA-specific knockdown was employed on cells vitro, use inhibitors. A xenografted mouse model established determine effect tumor suppression....
Systemic juvenile idiopathic arthritis (sJIA) accompanied with Brucella bloodstream and bone marrow infection is an exceedingly rare occurrence in clinical practice. Owing to the striking similarity their presentations, there a propensity for misdiagnosis or underdiagnosis. In this case, pediatric patient underwent medical treatment across five different hospitals over three-month period before receiving accurate diagnosis successful treatment. There are two primary factors contributing...
Background The association between lung cancer and trace element levels, such as serum copper (Cu) zinc (Zn) levels the Cu:Zn ratio, vary among different demographic groups; however, it is unknown whether variations in Cu Zn ratios are related to prediction prognosis of cancer. We aimed clarify this relationship Han Chinese population Northeast China.Methods recruited 146 patients with age- resident area-matched cancer-free controls.Results Increased ratio were positively associated (OR:...
The rate of brucellosis, a zoonotic disease, has rapidly increased in humans brucellosis(HB) recent years. In 1950-2018, total 684,380 HB cases (median 2274/year (interquartile range (IQR) 966-8325)) were reported to the National Infectious Disease Surveillance System mainland China. incidence peaked 2014 (4.32/100,000), and then showed downward trend; we predict that it will maintain steady trend 2019-2020. Since 2015, shown opposite trends north south China; rates have fallen increased....
Due to the natural resistance of nontuberculous mycobacteria (NTM) many antibiotics, treatment diseases caused by NTM is often long-term but unsuccessful. The main goal this study was evaluate in vitro susceptibilities clofazimine 209 isolates consisting different species isolated Beijing, China. Furthermore, 47 reference strains were also tested, including 30 rapidly growing mycobacterium (RGM) and 17 slowly (SGM) species. potential molecular mechanism contributing investigated as well....
Abstract The c-Jun N-terminal kinase (JNK) pathway plays essential roles in regulating a variety of physiological processes including cell migration and invasion. To identify critical factors that regulate JNK-dependent migration, we carried out genetic screen Drosophila based on the loss-of-cell polarity-triggered wing epithelia, identified MKK3 licorne ( lic ) as an regulator JNK-mediated We found loss suppressed ptc > scrib-IR or Egr triggered Ras v12 /lgl −/− induced tumor invasion...
Despite their high accuracy to recognize oral potentially malignant disorders (OPMDs) with cancer risk, non-invasive assays are poor in discerning whether the risk is or low. However, it critical identify levels, since high-risk patients need active intervention, while low-risk ones simply be follow-up. This study aimed at developing a personalized computational model predict level of OPMDs and explore its potential web application screening.Each enrolled patient was subjected following...
This study investigates visitors’ attitudes towards the reopening of Chimelong Ocean Kingdom in China amid global pandemic 2020. The proposed framework utilizes Push-Pull-Mooring model by adapting THEMEQUAL dimensions. Seven perceptual variables are identified as a source arising from their theme park experiences. findings reveal that is leading to change which PPM factors most influence decision revisit park. It proposes industry should put these important together order develop cohesive...
Due to the natural resistance of nontuberculous mycobacteria (NTM) against multiple antibiotics, treatment infections caused by them is often long-course and less successful. The main objective our study was evaluation in vitro susceptibility 209 isolates consisting different NTM species bedaquiline delamanid. Furthermore, reference strains 33 rapidly growing mycobacterium (RGM) 19 slowly (SGM) were also tested. Bedaquiline exhibited strong activity both clinical SGM species, as majority...
Tumor-associated dendritic cells (TADCs) can interact with tumor to suppress anti-tumor T cell immunity. However, there is no information on whether and how TADCs modulate programmed death-ligand 1 (PD-L1) expression by cancer cells.Human peripheral blood monocytes were induced for DCs immature cultured alone, or co-cultured bladder T24 control SV-HUC-1 cells, followed stimulating LPS DC activation. The activation status of was characterized flow cytometry allogenic proliferation. levels...
Cancer-associated fibroblasts (CAFs) have been shown to enhance squamous cell carcinoma (SCC) growth, but it is unclear whether they promote SCC lung metastasis. We generated CAFs from K15.KrasG12D.Smad4 –/– mouse SCCs. RNA expression analyses demonstrated that had enriched transforming growth factor-beta (TGFβ) signaling compared normal tissue-associated (NAFs), therefore we assessed how TGFβ-enriched impact co-injected cells with the skin, tail vein, or mimic sequential steps of increased...
In this study, we demonstrate that PBTZ169 exhibits significant differences in vitro activity against multiple Mycobacterium species. The amino acid polymorphism at codon 387 of decaprenylphosphoryl-beta-d-ribose oxidase (DprE1) can be used as a surrogate marker for susceptibility to mycobacteria. addition, the substitution 154 DprE1 may associated with acquired resistance fortuitum mutants.
Abstract Purpose: We previously reported preventive and therapeutic effects of Smad7, a multifunctional protein, on radiotherapy (RT)-induced mucositis in mice without promoting human oral cancer cell survival or migration vitro. The current study aims to determine whether Smad7-based biologic can treat existing during for this treatment compromises RT-induced killing neighboring cancer. Experimental Design: transplanted cells into the tongues applied craniofacial irradiation simultaneously...
Autophagy is involved in human apical periodontitis (AP). However, it not clear whether autophagy protective or destructive bone loss via the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) axis. This study aimed to investigate involvement RANKL/RANK/OPG axis during development AP an experimental rat model.
This study aimed to identify reliable quantitative parameters of ultrasonic shear wave elastography (SWE) that demonstrate advantages in assessing the efficacy neoadjuvant chemotherapy (NAC) for breast cancer by comparison conventional ultrasound (US). research also analyzed associations between SWE and tumor collagen fibers from post-NAC lesions explore histological micro-mechanisms stiffness change after NAC. Forty-Seven examined with US were eligible enrollment January 2021 July 2023. The...