A5034045632- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Pneumonia and Respiratory Infections
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Enterobacteriaceae and Cronobacter Research
- Entrepreneurship Studies and Influences
- Listeria monocytogenes in Food Safety
- Land Use and Ecosystem Services
- Family Business Performance and Succession
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Soil Carbon and Nitrogen Dynamics
- Animal Nutrition and Physiology
- RNA and protein synthesis mechanisms
- Infections and bacterial resistance
- Bacterial Identification and Susceptibility Testing
Fudan University
2025
University of Arkansas at Fayetteville
2020-2025
Shenzhen Luohu People's Hospital
2023-2025
Sir Run Run Shaw Hospital
2015-2024
Zhejiang University
2015-2024
University of Oklahoma
2018-2024
Monash University
2024
Hainan University
2023-2024
Australian Regenerative Medicine Institute
2024
Nanchang University
2020-2024
Antibiotic-resistant ESKAPE pathogens cause nosocomial infections that lead to huge morbidity and mortality worldwide. Rapid identification of antibiotic resistance is vital for the prevention control infections. However, current techniques like genotype susceptibility testing are generally time-consuming require large-scale equipment. Herein, we develop a rapid, facile, sensitive technique determine phenotype among through plasmonic nanosensors machine learning. Key this sensor array...
Plants release a wealth of metabolites into the rhizosphere that can shape composition and activity microbial communities in response to environmental stress. The connection between rhizodeposition microbiome succession has been suggested, particularly under stress conditions, yet definitive evidence is scarce. In this study, we investigated relationship chemistry, dynamics, abiotic bioenergy crop switchgrass grown marginal soil nutrient-limited, moisture-limited, nitrogen (N)-replete,...
This study aimed to investigate the prevalence, serotype distribution, and antibiotic resistance, characterize extended spectrum β-lactamases (ESBLs) producing Salmonella isolates from chicken pork meats retail markets in Guangdong province, China. A total of 903 meat samples (475 428 meats) were obtained six cities (Guangzhou, Shenzhen, Heyuan, Shaoguan, Foshan, Yunfu) province between May 2016 April 2017. High levels contamination detected (302/475, 63.6%) (313/428, 73.1%). Thirty-eight...
Abstract Background The emergence and spread of New Delhi metallo-β-lactamase-producing Enterobacteriaceae has been a serious challenge to manage in the clinic due its rapid dissemination multi-drug resistance worldwide. As one main type carbapenemases, metallo-β-lactamase (NDM)is able confer almost all β-lactams, including carbapenems, . Recently, metallo-β-lactamase-5 attracted extensive attention because increased carbapenems widespread dissemination. However, mechanism bla NDM-5 gene...
Hypervirulent carbapenem-resistant
ABSTRACT The emergence and spread of New Delhi metallo-β-lactamase 1 (NDM-1)-producing carbapenem-resistant Enterobacteriaceae (CRE) present an urgent threat to human health. In China, the bla NDM-1 gene has been reported mostly in Acinetobacter spp. but is rarely found . Here, we report a high incidence endemic NDM-1-producing CRE Henan Province China. Sixteen (33.3%) 48 isolates obtained from patients during June 2011 July 2012 were positive for , was be carried on plasmids various sizes...
KPC-producing Klebsiella pneumoniae isolates have emerged as important pathogens of nosocomial infections, and tigecycline is one the antibiotics recommended for severe infections caused by K. pneumoniae. To identify susceptibility profile to investigate role efflux pumps in resistance, a total 215 were collected. The minimum inhibitory concentration (MIC) was determined standard broth microdilution tests. Isolates showing resistance underwent test with pump inhibitors. Expression levels...
The goal of this study was to investigate the epidemiological characteristics and surrounding genetic structure bla(NDM-1) in non-baumannii Acinetobacter spp. China.Non-baumannii were collected from 28 provinces China screened for presence using PCR. following four methods used classify isolates: Vitek 2 system, 16S-23S rRNA gene intergenic spacer sequencing, amplified rDNA restriction analysis partial rpoB sequence analysis. An S1-PFGE assay Southern blot hybridization performed determine...
Tigecycline is one of the last resort treatments for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. resistance often occurs during clinical treatment CRKP, yet its mechanism has still not been clearly elucidated. This study presents an analysis a tigecycline that developed in isolates from 56-year-old female patient infected with CRKP treatment. Consecutive clonal consistent K. were obtained Whole genome sequencing was performed, and putative single nucleotide polymorphisms...
The wetland ecosystem in the “Three-River Headwaters” (TRH) region plays an irreplaceable role water source conservation, run-off adjustment and biodiversity maintenance. In recent years, assessment of resources affected by climate changes has aroused enormous attention, since it can further protect provide a scientific basis for decision makers. this study, its response to TRH from early 1990s 2012 were analyzed remote sensing (RS) image interpretation change trend analysis. results showed...
Iron is an essential nutrient for bacterial survival and thus higher iron levels may precipitate infections. We investigated the association between serum level prognosis in patients with sepsis by using single-centre Medical Information Mart Intensive Care III (MIMIC-III) database. Sepsis parameters measured on ICU admission were included stratified according to quartiles of levels. A total 1,891 diagnosed Sepsis-3 criteria this study, 324 whom septic shock. After adjusting confounding...
A total of 2582 non-duplicate clinical Acinetobacter spp. isolates were collected to evaluate the performance four identification methods because it is important identify accurately and survey species distribution determine appropriate antimicrobial treatment. Phenotyping (VITEK 2 VITEK MS) genotyping (16S rRNA rpoB gene sequencing) applied for identification, susceptibility test imipenem meropenem was performed with a disk diffusion assay. Generally, phenotypic results quite different from...
ABSTRACT Production of the OXA-23 carbapenemase is most common reason for increasing carbapenem resistance in Acinetobacter spp. This study was conducted to reveal genetic basis bla dissemination China. A total 63 carbapenem-resistant OXA-23-producing sp. isolates, representing different backgrounds, were selected from 28 hospitals 18 provinces this study. Generally, two patterns plasmids carrying detected according S1-nuclease pulsed-field gel electrophoresis and Southern blot...
Abstract Background The study aims were to evaluate the species distribution and antimicrobial resistance profile of Gram-negative pathogens isolated from specimens intra-abdominal infections (IAI), urinary tract (UTI), respiratory (RTI), blood stream (BSI) in emergency departments (EDs) China. Methods From 2016 2019, 656 isolates collected 18 hospitals across Minimum inhibitory concentrations determined by CLSI broth microdilution interpreted according M100 (2021) guidelines. In addition,...
Background/Objective Several studies have described the epidemiological distribution of blaOXA-58-harboring Acinetobacter baumannii in China. However, there is limited data concerning replicon types blaOXA-58-carrying plasmids and genetic context surrounding blaOXA-58 spp. Methodology/Principal Findings Twelve non-duplicated isolates were collected from six hospitals five different cities between 2005 2010. The molecular epidemiology was carried out using PFGE multilocus sequence typing....
New Delhi metallo-β-lactamase-1 (NDM-1)-producing Enterobacteriaceae has disseminated rapidly throughout the world and poses an urgent threat to public health. Previous studies confirmed that blaNDM-1 gene is typically carried in plasmids but rarely chromosome. We discovered a multidrug-resistant Escherichia coli strain Y5, originating from urine sample containing gene, which did not transfer by either conjugation or electrotransformation. possibility of its chromosome location...
The emergence and spread of NDM-1-producing Enterobacteriaceae have resulted in a worldwide public health risk that has affected some provinces China. China is an exceptionally large country, there crucial need to investigate the epidemic blaNDM-1-positive our province. A total 186 carbapenem-resistant isolates (CRE) were collected grade-3 hospital Zhejiang Carbapenem-resistant genes, including blaKPC, blaIMP, blaVIM, blaOXA-48 blaNDM-1 screened sequenced. Ninety identified as harboring...