A5103225207- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Magnolia and Illicium research
- RNA Interference and Gene Delivery
- Regulation of Appetite and Obesity
- Postharvest Quality and Shelf Life Management
- Pharmacological Effects of Natural Compounds
- Nutrition and Health in Aging
- Neonatal and fetal brain pathology
- biodegradable polymer synthesis and properties
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Advanced oxidation water treatment
- Body Composition Measurement Techniques
- Bioactive Compounds and Antitumor Agents
- Advanced Polymer Synthesis and Characterization
- Biopolymer Synthesis and Applications
- Platelet Disorders and Treatments
- Angiogenesis and VEGF in Cancer
Second Xiangya Hospital of Central South University
2020-2025
Zunyi Medical University
2023-2025
Central South University
2020-2025
Hunan University
2024
Guangdong University of Petrochemical Technology
2024
Fudan University Shanghai Cancer Center
2024
Shandong Agricultural University
2023-2024
Chinese Academy of Sciences
2008-2023
Shanghai Institute of Materia Medica
2008-2023
Daqing Oilfield General Hospital
2023
A biodegradable sponge, composed of chitosan (CS) and sodium alginate (SA), was successfully obtained in this work. The sponge ethereal pliable. chemical structure morphology the sponges characterized by FTIR SEM. swelling ability, vitro drug release degradation behaviors, an vivo animal test were employed to confirm applicability as a wound dressing material. As content decreased, ability decreased. All types exhibited properties. curcumin from could be controlled crosslinking degree....
To realize the potential of large molecular weight substances to treat neurological disorders, novel approaches are required surmount blood–brain barrier (BBB). We investigated whether fusion a receptor-binding peptide from apolipoprotein E (apoE) with potentially therapeutic protein can bind LDL receptors on BBB and be transcytosed into CNS. A lysosomal enzyme, α- L -iduronidase (IDUA), was used for biological evaluation in mouse model mucopolysaccharidosis (MPS) type I, one most common...
Glucoraphanin was found to be the most abundant glucosinolate both in crude broccoli and after vitro gastrointestinal digestion, with a bioaccessibility of 46.2 ± 0.4%. has been reported as stable precursor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) inducer sulforaphane which correlated obesity. Thus, effects glucoraphanin on lipid metabolism gut microflora high-fat diet-fed mice were investigated. decreased liver weights adipose tissue masses, concentrations serum inflammatory...
Human calcium-sensing receptor (CaSR) is a G-protein-coupled that maintains Ca 2+ homeostasis in serum. Here, we present the cryo-electron microscopy structures of CaSR inactive and agonist+PAM bound states. Complemented with previously reported CaSR, show addition to full active states, there are multiple intermediate states during activation CaSR. We used negative allosteric nanobody stabilize fully state found new binding site for ion acts as composite agonist L-amino acid closure Venus...
A series of low molecular weight poly(ethylene glycol)–polycaprolactone–poly(ethylene glycol) (PEG–PCL–PEG) biodegradable block copolymers were successfully synthesized using isophorone diisocyanate (IPDI) as the coupling agent, and characterized 1H NMR Fourier transform infrared spectroscopy. The aqueous solutions PEG–PCL–PEG displayed a special thermosensitive gel–sol transition when concentration was above corresponding critical gel concentration. Gel–sol phase diagrams recorded...
Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of ε-caprolactone initiated poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared solvent diffusion method or w/o/w double emulsion method. obtained particles' morphology observed on scanning electron microscopy, and the particle size distribution determined using Malvern laser sizer. Bovine serum albumin used as model water-soluble protein drug, which successfully...
Abstract In this work, a new kind of biodegradable pH‐sensitive hydrogel was successfully synthesized by UV‐initiated free radical polymerization. The obtained characterized 1 H NMR and FTIR. Swelling behavior in different aqueous media pH responsivity the hydrogels were studied detail as well. With increase from 1.2 to 7.2, swelling ratio increased. morphology observed scanning electron microscopy, hydrolytic degradation also investigated work. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res 2008
Human leukocyte antigen (HLA)-G has been postulated as an important immunotolerant molecule in maintaining fetal-maternal relationship. Recent reports indicated that the 14-bp deletion/insertion polymorphism exon 8 of HLA-G gene influences mRNA stability and isoform splicing patterns, thus modulating levels expression. This might play immunomodulatory role during implantation pregnancy. In present study, 109 unrelated fertile control women 79 who had experienced recurrent spontaneous...
Patients with liver cirrhosis often experience factors such as malnutrition and lack of exercise, leading to reduced quality life. Insufficient social support is related self-management in patients chronic diseases. Therefore, this study explores the mediating role relationship between life, analyzing impact exercise frequency risk assessment on support, self-management, Using a convenience sampling method, cross-sectional data were collected from 257 at infectious disease department...
Abstract Human leukocyte antigen‐G (HLA‐G) molecule exerts multiple immunoregulatory functions that have been suggested to contribute the immune evasion of tumour cells. Studies on HLA‐G expression in malignant haematopoietic diseases are controversial, and this context limited. In current study, was analysed different types patients: de novo acute myeloid leukaemia (AML, n = 54), B cell lymphoblastic (B‐ALL, 13), chronic (CML, 9) myelodysplastic syndrome (MDS, 11). observed 18.5% cases AML,...
The critical role of blood supply in the growth solid tumours makes vessels an ideal target for anti-tumour drug discovery. anti-angiogenic and vascular disrupting activities C9, a newly synthesized microtubule-depolymerizing agent, were investigated with several vitro vivo models. Possible mechanisms involved its activity also assessed.Microtubule-depolymerizing actions assessed by surface plasmon resonance binding, competitive inhibition cytoskeleton immunofluorescence. Anti-angiogenic...
Abstract In this article, a kind of biodegradable poly(ϵ‐caprolactone)‐Poly(ethylene glycol)‐poly(ϵ‐caprolactone) (PCL‐PEG‐PCL, PCEC) copolymer was synthesized by ring‐opening polymerization method. The PCEC nanoparticles were prepared at one‐step modified emulsion solvent evaporation method using CTAB as stabilizer. With increase in concentration, the particle size increased obviously, but zeta potential only slightly. obtained cationic nanoparticle employed to condense and adsorb DNA onto...