A5101636730- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Angiogenesis and VEGF in Cancer
- Marine Sponges and Natural Products
- Lung Cancer Treatments and Mutations
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Phytochemical compounds biological activities
- Metal complexes synthesis and properties
- Natural product bioactivities and synthesis
- Lung Cancer Research Studies
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Bioactivity Studies
- Tendon Structure and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Synthesis of Indole Derivatives
- PI3K/AKT/mTOR signaling in cancer
- Cancer Immunotherapy and Biomarkers
- Fungal Biology and Applications
Panyu District Central Hospital
2016-2025
Panyu Hospital of Chinese Medicine
2017-2025
Guangzhou Medical University
2020-2025
Nanjing University of Chinese Medicine
2017-2025
Hebei Medical University
2025
Second Hospital of Hebei Medical University
2025
China University of Geosciences
2025
Sun Yat-sen University
2008-2025
China University of Geosciences (Beijing)
2024-2025
Sun Yat-sen Memorial Hospital
2025
A series of novel thiosemicarbazone derivatives bearing condensed heterocyclic carboxaldehyde moieties were designed and synthesized. Among them, TSC24 exhibited broad antiproliferative activity in a panel human tumor cells suppressed growth mice. The mechanism research revealed that was not only an iron chelator but also topoisomerase IIα catalytic inhibitor. Its inhibition on due to direct interaction with the ATPase domain which led block ATP hydrolysis. Molecular docking predicted might...
The use of immune checkpoint inhibitors (ICI) can lead to immune-related adverse events (irAE), which skin irAE is common, affecting up 50% ICI-treated patients. Although only a few cases subacute cutaneous lupus erythematosus (SCLE) have been reported in patients receiving anti-programmed death-1(anti-PD-1) immunotherapy, it important identify ICI-induced SCLE because may cause delayed and/or prolonged reactions even after treatment discontinuation. To date, no associated with Camrelizumab...
Developing highly‐efficient and robust bifunctional electrocatalyst for overall water splitting (OWS) is desirable, but it confronts long‐term challenge in the local structural reconstruction of catalyst during hydrogen oxygen evolution reaction (HER OER). As inspired by stable acid‐base buffer system human life, here we construct an electron to well address key issue reconstruction, which charge‐buffered fullerene renders Ru‐based active species be reversibly shuttled between Ru RuO2 HER...
AbstractHere, we examined the in vitro and vivo anti-angiogenesis anti-tumor activities of PE, a new marine-derived compound. Inhibition angiogenesis was assessed using proliferation, migration, adhesion, tube-formation apoptosis assays PE-treated HMECs HUVECs. In vivo, CAM were used to assess inhibition effect PE on physiological angiogenesis, immunofluorescent microscopy examine tumor microvessel density mouse models. Finally, Western blotting analyses performed VEGF signaling HMECs. The...
AbstractDihydroartemisinin (DHA), the main active metabolite of artemisinin derivatives, is one most effective anti-malarial analogs artemisinin. In current study, we found that DHA inhibited proliferation a panel tumor cells originated from different tissue types. effectively induced apoptosis in human promyelocytic leukemia HL-60 cells, which was accompanied with mitochondrial dysfunction and caspases activation. Further studies indicated DHA-induced iron-dependent. Though slightly...
Abstract This study is intended to characterize the cellular target of gambogic acid (GA), a natural product isolated from gamboge resin Garcinia hurburyi tree, which possesses potent in vitro and vivo antitumor activities. The antiproliferative activity GA was further confirmed here panel human tumor cells multidrug-resistant cells. We found that significantly inhibited catalytic topoisomerase (Topo) II and, comparatively less extent, Topo I, without trapping stabilizing covalent...
Abstract The low dielectric polymer films have drawn great attention to the application as insulating materials in high‐frequency circuit boards, while weak adhesion copper foils and poor processability resulted from fluorinated or rigid structures limited their application. In this work, high adhesive polyimide/fluorinated ethylene propylene (PI/FEP) nanocomposite film for flexible board is developed. It indicated that fluorocarbon surfactants can significantly improve dispersion of FEP PI...
Abstract Philinopside A is a novel sulfated saponin isolated from the sea cucumber, Pentacta quadrangulari . The effects of philinopside on angiogenesis and tumor growth were assessed in series models vitro vivo Our results demonstrated that significantly inhibited proliferation, migration tube formation human microvascular endothelial cells (HMECs) dose‐dependent manner, with average IC 50 values 1.4 ± 0.17, 0.89 0.23 0.98 0.19 μM, respectively. Rat aortas culture assay provides close...
Abstract Purpose: This study aimed to evaluate antitumor activities and pharmacologic profiles of chimmitecan, a novel 9-small-alkyl–substituted lipophilic camptothecin, in comparison with irinotecan (CPT-11) topotecan. Experimental Design: The vitro cytotoxities chimmitecan human tumor cell lines multidrug resistance (MDR) cells were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide sulforhodamin B assays. DNA relaxation, cleavage assays, cellular band depletion...
Tubulin-binding agents have received considerable interest as potential tumor-selective angiogenesis-targeting drugs. Herein, we report that pseudolarix acid B (PAB), isolated from the traditional Chinese medicinal plant <i>Pseudolarix kaempferi</i> Gordon, is a tubulin-binding agent. We further demonstrate PAB significantly and dose-dependently inhibits proliferation, migration, tube formation by human microvessel enthothelial cells. It noteworthy eliminated newly formed endothelial tubes...
Protein tyrosine kinase (PTK) inhibitors represent emerging therapeutics for cancer chemoprevention. In our study, hematoxylin (26) was identified as one of the most remarkable c-Src in an orthogonal compound-mixing library (32200 compounds) by using ELISA-based automated high-throughput screening (HTS) strategy. Interestingly, found to be ATP competitive broad-spectrum PTK inhibitor vitro, with IC50 values ranging from nanomolar micromolar level. Further studies showed that such inhibition...
Understanding hub genes involved in gastric cancer (GC) metastasis could lead to effective approaches diagnose and treat metastasis. In this study, 272 differentially expressed between synchronous liver the paired GC were selected from microarray assays. KEGG pathway analysis indicated that of 13 enriched pathways, 8 Literature-based annotations showed significantly known metastasis-related genes. With use protein-protein interaction network, we found a subnetwork enriching hubs. Unannotated...
Abstract Background Diabetes mellitus is associated with tendinopathy or tendon injuries. However, the mechanism underlying diabetic unclear. The purpose of this study was to examine effects high glucose concentrations on activity and expression matrix metalloproteinases, type I collagen, III collagen in cells. Methods Tendon cells from rat Achilles tendons were treated 6 mM, 12 25 mM glucose, then cell proliferation evaluated by 3-[4,5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide...
Staphylococcus aureus is an important pathogen that forms biofilms on the surfaces of medical implants. Biofilm formation by S. associated with production poly N-acetylglucosamine (PNAG), also referred to as polysaccharide intercellular adhesin (PIA), which mediates bacterial adhesion, leading accumulation bacteria solid surfaces. This study shows ability SA113 adhere nasal epithelial cells reduced after deletion ica operon, contains genes encoding PIA/PNAG synthesis. However, this restored...
Background: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on authors’ previous study, PRP releasate can promote proliferation migration skeletal muscle cells in vitro, so animal studies are performed support use treat injury vivo. Purpose: To investigate effect regeneration muscle, as well its inflammatory reaction cell apoptosis, early stages muscle-healing process. Study Design: Controlled...
Abstract Purpose: Pseudolaric acid B (PAB), the naturally occurring diterpenoid isolated from root bark of Pseudolarix kaempferi Gordon tree (Pinaceae), possesses potent antifungal and pregnancy-terminating effects that may be tightly associated with angiogenesis. This study was to examine its angiogenic inhibition, impact on vascular endothelial growth factor (VEGF) secretion tumor cells possible mechanism action. Experimental Design: Angiogenesis inhibition assessed by human umbilical cell...
Four novel tetranortriterpenoids, xylogranatins A−D (1−4), with an unusual 9,10-seco skeleton were isolated from the seeds of a Chinese marine mangrove Xylocarpus granatum. Their structures determined by spectroscopic and chemical means. Xylogranatin A (1) featured unique 1,9-oxygen bridge was confirmed single-crystal X-ray diffraction, xylogranatin D (4) unprecedented C-30−C-9 linkage postulated biogenetically 3 via α-hydroxyl ketone rearrangement chemically mimicked.
Background: Previous studies have reported that epidermal growth factor receptor (EGFR) mutation in tumor tissue and peripheral blood can predict the response to EGFR tyrosine kinase inhibitor (TKI) non-small cell lung cancer (NSCLC). However, heterogeneity of sample sources makes it difficult evaluate detecting methodologies. The goal this study is compare different methods for analyzing tissue. Materials methods: Fifty-one advanced NSCLC patients treated with gefitinib were included study....