A5067408527- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Intensive Care Unit Cognitive Disorders
- Pluripotent Stem Cells Research
- Histone Deacetylase Inhibitors Research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Regulation of Appetite and Obesity
- Tissue Engineering and Regenerative Medicine
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Stress, Anesthesia, and Immune Response
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
Xi'an Jiaotong University
2015-2024
Shanghai Ninth People's Hospital
2024
Inner Mongolia Electric Power (China)
2023-2024
Shanghai Jiao Tong University
2024
Ningxia Medical University
2019-2020
Institute of Neurobiology
2019
Shanxi Medical University
2015
Oil Crops Research Institute
2013
Chinese Academy of Agricultural Sciences
2013
University of Pennsylvania
2012
Alcoholic liver disease (ALD) presents one of the leading causes cirrhosis worldwide. We have demonstrated that inulin alleviates ALD in mice. However, exact role hepatic macrophages effects on remains largely unclear.In vivo, mice were divided into 4 groups: pair-fed (PF) group (PF/CON), alcohol-fed (AF) (AF/CON), PF with (INU) (PF/INU) and AF INU (AF/INU). Each was fed modified Lieber-DeCarli liquid diet or without alcohol. In vitro, RAW264.7 cell lines polarized to M1 macrophage (Mψ) M2...
Polycystic ovary syndrome (PCOS) represents a common endocrine-metabolic disorder disease with chronic low-grade inflammation and alteration of intestinal flora. Serving as functional food, flaxseed oil (FO), which is rich in plant-derived α-linolenic acid omega-3 polyunsaturated fatty acids, has been proven to benefit for metabolic diseases. However, the exact role dietary FO on PCOS remains largely unclear. In present study, 6-week-old female Sprague-Dawley rats were randomly divided into...
Hypoxic preconditioning (HPC) exerts a protective effect against hypoxic/ischemic brain injury, and one mechanism explaining this may involve the upregulation of hypoxia-inducible factor-1 (HIF-1). Autophagy, an endogenous is correlated with activation HIF-1α/Beclin1 signaling pathway. Based on previous studies, we hypothesize that role HPC autophagy occurring via To test hypothesis, evaluated effects oxygen-glucose deprivation/reperfusion (OGD/R)-induced apoptosis in SH-SY5Y cells....
Cerebral palsy (CP) is a common disability which results in permanent chronic motor appearing early childhood. Recently human umbilical cord blood mesenchymal stem cell (hUCB-MSC) infusion has emerged as promising therapeutic strategy for CP, and the treatment efficacy remains to be confirmed by clinical trials. All 54 patients received basic rehabilitation background treatment. The group comprising 27 4 infusions of hUCB-MSCs (intravenous at fixed dose 5 × 107) treatment, whereas control...
Background: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic worldwide with chronic low-grade inflammation and alteration of gut microbiota. Inulin (INU) has been confirmed to exhibit benefit for diseases. The aim this study was clarify the effects mechanism INU on NAFLD via gut-liver axis. Methods: C57BL/6 mice were randomly divided into four groups: normal diet group (ND); high-fat (HFD); ND (ND-INU); HFD (HFD-INU). After 14 weeks feeding, sacrificed associated indications...
Neurogenesis and angiogenesis are two important processes that may contribute to the repair of brain injury after stroke. This study was designed investigate whether transplantation human embryonic neural stem cells (NSCs) into cortical peri-infarction 24h ischemia effects cell proliferation in subventricular zone (SVZ) peri-infarct zone. NSCs were prepared from brains at 8 weeks gestation. Focal cerebral induced by permanent occlusion middle artery adult rats. Animals randomly divided...
In vitro neurovascular unit (NVU) models are valuable for investigating brain functions and developing drugs. However, it remains challenging to recapitulate the native architectural features ultra-soft extracellular matrix (ECM) properties of natural NVU. Cell-laden bioprinting is promising prepare complex living tissues, but hard balance fidelity cell growth. This study proposes a novel two-stage methodology biomanufacturing functional 3D constructs in with low modulus ECM. At shaping...
The main objective of this study was to evaluate the potential a sesame (Sesamum indicum L.) panel for association analysis, and investigate genetic basis oil content (OC), protein content, oleic acid concentration, linoleic concentration using mapping. A 216 accessions phenotyped in multi-environment trial fingerprinted with 608 polymorphic loci produced by 79 primers, including simple sequence repeats (SSRs), sequence-related amplified polymorphisms (SRAPs), fragment length (AFLPs)....
Neural stem cells (NSCs) persist in the subgranular zone (SGZ) throughout lifespan and hold immense potential for repair regeneration of central nervous system, including hippocampal-related diseases. Several studies have demonstrated that cellular communication network protein 3 (CCN3) regulates multiple types cells. However, role CCN3 NSCs remains unknown. In this study, we identified expression mouse hippocampal observed supplementing improved cell viability a concentration-dependent...
Promoting both endogenous and exogenous neural stem cells' (NSCs) survival in the hostile host environments is essential to cell replacement therapy for central nervous system (CNS) disorders. Type 4 metabotropic glutamate receptor (mGluR4), one of members mGluRs, has been shown protect neurons from acute chronic excitotoxic insults various brain damages. The present study investigated preventive effects mGluR4 on NSC injury induced by oxidative stress. Under challenge with H2O2, loss...
Cell-cell interaction as one of the niche signals plays an important role in balance stem cell quiescence and proliferation or differentiation. In order to address effect possible mechanisms cell-cell connection on neural stem/progenitor cells (NSCs/NPCs) differentiation, upon passaging, NSCs/NPCs were either dissociated into single usual (named Group I) mechanically triturated a mixture small clusters containing direct connections II). Then biological behaviors including differentiation...
It has been suggested that ketamine cause injury during developing brain. Minocycline (MC) could prevent neuronal cell death through the activation of survival signals and inhibition apoptotic in models neurodegenerative diseases. Here we investigated protective effect MC against ketamine-induced neural stem cells (NSCs) from neonatal rat. Ketamine (100 μM/L) significantly inhibited NSC proliferation, promoted their differentiation into astrocytes suppressed NSCs. Moreover, level was...
The potential of neural stem cells (NSCs) for neurological disorders the treatment has relied in large part upon identifying NSCs fate decision. hormone leptin been reported to be a crucial regulator brain development, able influence glial and yet, underlying mechanism acting on NSCs' biological characteristics is still poorly understood. This study aims investigate role properties NSCs. In this study, we possibility that may regulate decision, which promote proliferation neuronal...
Edaravone is clinically used for treatment of patients with acute cerebral infarction. However, the effect double application edaravone on neurogenesis in hippocampus following ischemia remains unknown. In present study, we explored whether pre- and posttreatment had any neural stem/progenitor cells (NSPCs) subgranular zone a rat model transient global elucidated potential mechanism its effects. Male Sprague-Dawley rats were divided into three groups: sham-operated ( n = 15), control...
Background/Aims: Ketamine inhibits the proliferation of neural stem cells (NSCs) and disturbs normal neurogenesis. Dexmedetomidine provides neuroprotection against volatile anesthetic-induced neuroapoptosis cognitive impairment in developing brain. Whether it may protect NSCs from ketamine-induced injury remains unknown. In this study, we investigated protective effects dexmedetomidine on ketamine-exposed explored mechanisms potentially involved. Methods: Primary NSC cultures were...
Because posttraumatic inflammation contributes to the progression of neuron degeneration, attenuating is important for reducing neural degeneration. Sirtuin 1 (SIRT1) has been shown play a critical role in chronic diseases, such as neurodegenerative diseases and aging. However, that SIRT1 plays regulating neuroinflammation spinal cord injuries (SCIs) remains unclear. In this study, we investigate effect on SCI model lipopolysaccharide (LPS)-treated primary microglia using pharmacological...
Abstract Background and Aims Dendritic cells (DCs) are closely related to blood pressure (BP) regulation. Mineralocorticoid receptor (MR) is an important drug target for antihypertensive treatment. However, the role of DC MR in pathogenesis hypertension has not been fully elucidated. This study aimed determine BP regulation explore mechanism. Methods Renal biopsy peripheral samples were collected from hypertensive patients (HTN) immunostaining flow cytometry. cell knockout (DCMRKO) mice,...